Interrupted adenylation domains: unique bifunctional enzymes involved in nonribosomal peptide biosynthesis

2015 ◽  
Vol 32 (5) ◽  
pp. 641-653 ◽  
Author(s):  
Kristin J. Labby ◽  
Stoyan G. Watsula ◽  
Sylvie Garneau-Tsodikova
Keyword(s):  
Amino Acid ◽  
Adenylation Domain ◽  
Nonribosomal Peptide ◽  
Bifunctional Enzymes ◽  
Peptide Biosynthesis ◽  
Single Enzyme

This highlight focuses on one of Nature's key strategies to doubly modify an amino acid during nonribosomal peptide biosynthesis by using a single enzyme, an interrupted adenylation domain.

Introduction of a Non-Natural Amino Acid into a Nonribosomal Peptide Antibiotic by Modification of Adenylation Domain Specificity

2012 ◽  
Vol 51 (29) ◽  
pp. 7181-7184 ◽  
Author(s):  
Jenny Thirlway ◽  
Richard Lewis ◽  
Laura Nunns ◽  
Majid Al Nakeeb ◽  
Matthew Styles ◽  
...  
Keyword(s):  
Amino Acid ◽  
Domain Specificity ◽  
Peptide Antibiotic ◽  
Adenylation Domain ◽  
Natural Amino Acid ◽  
Nonribosomal Peptide

Introduction of a Non-Natural Amino Acid into a Nonribosomal Peptide Antibiotic by Modification of Adenylation Domain Specificity

2012 ◽  
Vol 124 (29) ◽  
pp. 7293-7296 ◽  
Author(s):  
Jenny Thirlway ◽  
Richard Lewis ◽  
Laura Nunns ◽  
Majid Al Nakeeb ◽  
Matthew Styles ◽  
...  
Keyword(s):  
Amino Acid ◽  
Domain Specificity ◽  
Peptide Antibiotic ◽  
Adenylation Domain ◽  
Natural Amino Acid ◽  
Nonribosomal Peptide

Engineered Nonribosomal Peptide Synthetase Shows Opposite Amino Acid Loading and Condensation Specificity

ACS Catalysis ◽  
2021 ◽  
pp. 8692-8700
Author(s):  
Aleksa Stanišić ◽  
Annika Hüsken ◽  
Philipp Stephan ◽  
David L. Niquille ◽  
Jochen Reinstein ◽  
...  
Keyword(s):  
Amino Acid ◽  
Nonribosomal Peptide Synthetase ◽  
Nonribosomal Peptide ◽  
Peptide Synthetase ◽  
Acid Loading

Nonribosomal Peptide Biosynthesis: Point Mutations and Module Skipping Lead to Chemical Diversity

2006 ◽  
Vol 45 (14) ◽  
pp. 2296-2301 ◽  
Author(s):  
Silke C. Wenzel ◽  
Peter Meiser ◽  
Tina M. Binz ◽  
Taifo Mahmud ◽  
Rolf Müller
Keyword(s):  
Point Mutations ◽  
Chemical Diversity ◽  
Nonribosomal Peptide ◽  
Peptide Biosynthesis

scholarly journals Rational Design of a Bimodular Model System for the Investigation of Heterocyclization in Nonribosomal Peptide Biosynthesis

2004 ◽  
Vol 11 (2) ◽  
pp. 261-271 ◽  
Author(s):  
Thomas Duerfahrt ◽  
Katrin Eppelmann ◽  
Rolf Müller ◽  
Mohamed A. Marahiel
Keyword(s):  
Rational Design ◽  
Model System ◽  
Nonribosomal Peptide ◽  
Peptide Biosynthesis
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