A highly selective fluorescent ‘turn-on’ chemosensor for Hg2+ based on a phthalazin-hydrazone derivative and its application in human cervical cancer cell imaging

2015 ◽  
Vol 39 (4) ◽  
pp. 3071-3076 ◽  
Author(s):  
Dipesh Mahajan ◽  
Nilesh Khairnar ◽  
Banashree Bondhopadhyay ◽  
Suban K. Sahoo ◽  
Anupam Basu ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Cell ◽  
Cell Imaging ◽  
High Selectivity ◽  
Fluorescence Enhancement ◽  
Cervical Cancer Cell ◽  
Turn On ◽  
Human Cervical Cancer Cell ◽  
Hydrazone Derivative ◽  
Human Cervical Cancer

Sensor 1 showed a high selectivity and sensitivity towards Hg2+ by giving significant fluorescence enhancement.

scholarly journals β-hydroxyisovaleryl-shikonin induces human cervical cancer cell apoptosis via PI3K/AKT/mTOR signaling

2015 ◽  
Vol 10 (6) ◽  
pp. 3434-3442 ◽  
Author(s):  
DAN LU ◽  
JING QIAN ◽  
WEI LI ◽  
QIANQIAN FENG ◽  
SHU PAN ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Mtor Signaling ◽  
Cervical Cancer Cell ◽  
Cancer Cell Apoptosis ◽  
Human Cervical Cancer Cell ◽  
Human Cervical Cancer

Benzylisoquinoline alkaloids from Nelumbo nucifera Gaertn. petals with antiausterity activities against the HeLa human cervical cancer cell line

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Juthamart Maneenet ◽  
Ashraf M. Omar ◽  
Sijia Sun ◽  
Min Jo Kim ◽  
Supawadee Daodee ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Nelumbo Nucifera ◽  
Cervical Cancer Cell ◽  
Cervical Cancer Cell Line ◽  
Benzylisoquinoline Alkaloids ◽  
Human Cervical Cancer Cell ◽  
Human Cervical Cancer

Abstract Ethanolic extract of Nelumbo nucifera petals showed preferential cytotoxic activity against HeLa human cervical cancer cell line with a PC50 value of 10.4 μg/mL. This active extract was subjected to a phytochemical investigation study which led to the isolation of nine benzylisoquinoline alkaloids (1–9). The isolated compounds exhibited potent antiausterity activities. Moreover, under nutrient-deprived conditions, (−)-lirinidine (8) induced remarkable alterations in HeLa cell morphology including cell shrinkage and plasma blebbing leading to total cell death within 10 h. Mechanistically, 8 was found to inhibit Akt/mTOR signaling pathway. It also induced apoptosis by promoting caspase-3 activation and inhibiting Bcl-2 expression. Therefore, benzylisoquinoline alkaloids skeleton can be considered as a promising scaffold for the anticancer drug development against cervical cancer.

scholarly journals Cervical Cancer Correlates with the Differential Expression of Nicotinic Acetylcholine Receptors and Reveals Therapeutic Targets

Marine Drugs ◽  
2019 ◽  
Vol 17 (5) ◽  
pp. 256 ◽  
Author(s):  
Yiqiao Liu ◽  
Jiang Qian ◽  
Zhihua Sun ◽  
Dongting Zhangsun ◽  
Sulan Luo
Keyword(s):  
Cervical Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Cervical Cancer Cell ◽  
Nicotinic Acetylcholine ◽  
Nachr Subtype ◽  
Human Cervical Cancer Cell ◽  
Human Cervical Cancer

Nicotinic acetylcholine receptors (nAChRs) are associated with various cancers, but the relation between nAChRs and cervical cancer remains unclear. Therefore, this study investigated the differential expression of nAChR subunits in human cervical cancer cell lines (SiHa, HeLa, and CaSki) and in normal ectocervical cell lines (Ect1/E6E7) at mRNA and protein levels. Two specific nAChR subtype blockers, αO-conotoxin GeXIVA and α-conotoxin TxID, were then selected to treat different human cervical cancer cell lines with specific nAChR subtype overexpression. The results showed that α3, α9, α10, and β4 nAChR subunits were overexpressed in SiHa cells compared with that in normal cells. α9 and α10 nAChR subunits were overexpressed in CaSki cells. α*-conotoxins that targeted either α9α10 or α3β4 nAChR were able to significantly inhibit cervical cancer cell proliferation. These findings may provide a basis for new targets for cervical cancer targeted therapy.

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