Design, synthesis and biological evaluation of thiourea and nicotinamide-containing sorafenib analogs as antitumor agents

MedChemComm ◽  
2015 ◽  
Vol 6 (5) ◽  
pp. 867-870 ◽  
Author(s):  
Xiangkai Kong ◽  
Zeyu Yao ◽  
Zuopeng He ◽  
Wenfang Xu ◽  
Jianwen Yao
Keyword(s):  
Antitumor Agents ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Thiourea and nicotinamide-containing sorafenib analogs with better antiproliferative and anti-angiogenic activities than sorafenib were well designed and synthesized.

ChemInform Abstract: Antitumor Agents. Part 202. Novel 2′-Amino Chalcones: Design, Synthesis, and Biological Evaluation.

ChemInform ◽  
2010 ◽  
Vol 31 (29) ◽  
pp. no-no
Author(s):  
Yi Xia ◽  
Zheng-Yu Yang ◽  
Peng Xia ◽  
Kenneth F. Bastow ◽  
Yuka Nakanishi ◽  
...  
Keyword(s):  
Antitumor Agents ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Design, synthesis, and biological evaluation of sorafenib derivatives containing indole (ketone) semicarbazide analogs as antitumor agents

2020 ◽  
Vol 57 (6) ◽  
pp. 2548-2560
Author(s):  
Wen Li ◽  
Ya‐Yun Qi ◽  
Yuan‐Yuan Wang ◽  
Yi‐Yuan Gan ◽  
Li‐Hui Shao ◽  
...  
Keyword(s):  
Antitumor Agents ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

scholarly journals Design, synthesis and biological evaluation of tryptamine salicylic acid derivatives as potential antitumor agents

MedChemComm ◽  
2019 ◽  
Vol 10 (4) ◽  
pp. 573-583 ◽  
Author(s):  
Runde Xiong ◽  
Dongxiu He ◽  
Xiangping Deng ◽  
Juan Liu ◽  
Xiaoyong Lei ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Salicylic Acid ◽  
Antitumor Agents ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Combination Principle ◽  
Salicylic Acid Derivatives ◽  
Synthesis And Biological Evaluation ◽  
Tumor Agent ◽  
Potential Antitumor

According to the combination principle, target compounds were designed, and compound E20 might be a promising anti-tumor agent targeting gastric cancer.

Design, synthesis and biological evaluation of phenylpicolinamide sorafenib derivatives as antitumor agents

2017 ◽  
Vol 27 (2) ◽  
pp. 374-387 ◽  
Author(s):  
Chunjiang Wu ◽  
Shan Xu ◽  
Yuping Guo ◽  
Jielian Wu ◽  
Rong Luo ◽  
...  
Keyword(s):  
Antitumor Agents ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation
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