Cytotoxic potential of dispirooxindolo/acenaphthoquino andrographolide derivatives against MCF-7 cell line

MedChemComm ◽  
2015 ◽  
Vol 6 (4) ◽  
pp. 702-707 ◽  
Author(s):  
Debanjana Chakraborty ◽  
Arindam Maity ◽  
Chetan K. Jain ◽  
Abhijit Hazra ◽  
Yogesh P. Bharitkar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Cell Line ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Cytotoxic Potential ◽  
Cell Death Pathway ◽  
Line P ◽  
Mcf 7

Dispiro andrographolides induce a caspase-dependent apoptotic cell death pathway in breast cancer (MCF-7) cells.

L-A03, a dihydroartemisinin derivative, promotes apoptotic cell death of human breast cancer MCF-7 cells by targeting c-Jun N-terminal kinase

2018 ◽  
Vol 105 ◽  
pp. 320-325 ◽  
Author(s):  
Guo-Dong Yao ◽  
Meng-Yao Ge ◽  
Dan-Qi Li ◽  
Ling Chen ◽  
Toshihiko Hayashi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Human Breast Cancer ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Human Breast ◽  
Mcf 7

scholarly journals Ricinus communis Butanol Fraction Inhibits MCF-7 Breast Cancer Cell Migration, Adhesion, and Invasiveness

2021 ◽  
Vol 20 ◽  
pp. 153473542097768
Author(s):  
Rixile Mabasa ◽  
Kholofelo Malemela ◽  
Karabo Serala ◽  
Mante Kgakishe ◽  
Thabe Matsebatlela ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Cell Migration ◽  
Cell Viability ◽  
Apoptotic Cell ◽  
Ricinus Communis ◽  
Gelatin Zymography ◽  
Apoptotic Cell Death ◽  
Butanol Fraction ◽  
Mcf 7

In this study, the potential of an n-butanol fraction from Ricinus communis to prevent metastasis in MCF-7 breast cancer cells was investigated. The effect of the fraction on BUD-8 and MCF-7 cell viability was assessed using the MTT assay. Apoptotic cell death was analyzed by Hoechst staining assay. The antimetastatic effect of the fraction on MCF-7 cell was evaluated using the wound healing, adhesion and Boyden chamber invasion assays. Gelatin-zymography was used to assess the effect of the fraction on MMP-2 and MMP-9 activity. The expression profile of proteins implicated in metastasis and angiogenesis was determined using the human angiogenesis antibody array kit, following treatment with the fraction. BUD-8 cell viability was significantly reduced at concentrations between 300 and 500 µg/ml of the extract. In contrast, a significant reduction in cell viability was seen in MCF-7 cells treated with 400 to 500 µg/ml of the fraction. At sub-lethal concentrations (100 and 200 µg/ml) of the fraction, no nuclei morphological changes associated with apoptotic cell death were observed in MCF-7 cells. In addition, the fraction showed to have an inhibitory effect on MCF-7 cell migration, adhesion, invasiveness, and MMP-2 activity. Moreover, the fraction was seen to modulate the expression of several proteins, such as MMP-9, uPA, VEGF, and TGF-β1, playing a role in the metastasis process. This study demonstrates that the n-butanol fraction of R. communis can inhibit major steps of the metastatic cascade and modulate metastasis regulatory proteins. Thus, the fraction can be considered a potential source of antimetastatic agents that could be useful in the treatment of malignant cancers.

Cadmium modulates H-ras expression and caspase-3 apoptotic cell death in breast cancer epithelial MCF-7 cells

2013 ◽  
Vol 121 ◽  
pp. 100-107 ◽  
Author(s):  
Savvas Petanidis ◽  
Margarita Hadzopoulou-Cladaras ◽  
Athanasios Salifoglou
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Caspase 3 ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Mcf 7

scholarly journals Substance P Receptor Signaling Mediates Doxorubicin-Induced Cardiomyocyte Apoptosis and Triple-Negative Breast Cancer Chemoresistance

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Prema Robinson ◽  
Moses Kasembeli ◽  
Uddalak Bharadwaj ◽  
Nikita Engineer ◽  
Kris T. Eckols ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Substance P ◽  
Cell Viability ◽  
Cell Line ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Ros Production

Doxorubicin (DOX), an anthracycline, is broadly considered the most active single agent available for treating breast cancer but has been known to induce cardiotoxicity. Although DOX is highly effective in treating triple-negative breast cancer (TNBC), DOX can have poor outcomes owing to induction of chemoresistance. There is an urgent need to develop new therapies for TNBC aimed at improving DOX outcome and DOX-induced cardiotoxicity. Substance P (SP), a neuropeptide involved in pain transmission is known to stimulate production of reactive oxygen species (ROS). Elevated cardiac ROS is linked with heart injury and failure. We investigated the role of SP in chemotherapy-associated death of cardiomyocytes and chemoresistance. We showed that pretreating a cardiomyocyte cell line (H9C2) and a TNBC cell line (MDA-MB 231) with aprepitant, a SP receptor antagonist that is routinely used to treat chemotherapy-associated associated nausea, decreased DOX-induced reduction of cell viability, apoptotic cell death, and ROS production in cardiomyocytes and increased DOX-induced reduction of cell viability, apoptotic cell death, and ROS production in TNBC cells compared with cells treated with DOX alone. Our findings demonstrate the ability of aprepitant to decrease DOX-induced killing of cardiomyocytes and to increase cancer cell sensitivity to DOX, which has tremendous clinical significance.

Sulindac induces apoptotic cell death in susceptible human breast cancer cells through, at least in part, inhibition of IKKβ

APOPTOSIS ◽  
2009 ◽  
Vol 14 (7) ◽  
pp. 913-922 ◽  
Author(s):  
A-Mi Seo ◽  
Seung-Woo Hong ◽  
Jae-Sik Shin ◽  
In-Chul Park ◽  
Nam-Joo Hong ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Human Breast Cancer Cells ◽  
Human Breast
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