Elucidation of the shanorellin biosynthetic pathway and functional analysis of associated enzymes

MedChemComm ◽  
2015 ◽  
Vol 6 (3) ◽  
pp. 425-430 ◽  
Author(s):  
Michio Sato ◽  
Haruka Yamada ◽  
Kinya Hotta ◽  
Kenji Watanabe
Keyword(s):  
Functional Analysis ◽  
Natural Products ◽  
Biosynthetic Pathway ◽  
Biological Activities ◽  
Polyketide Synthases ◽  
Fungal Natural Products

Since fungal natural products biosynthesized by polyketide synthases frequently exhibit useful biological activities, identifying and understanding the mechanism of biosynthetic steps taken by PKSs are of great interest.

scholarly journals Biosynthetic investigation of phomopsins reveals a widespread pathway for ribosomal natural products in Ascomycetes

2016 ◽  
Vol 113 (13) ◽  
pp. 3521-3526 ◽  
Author(s):  
Wei Ding ◽  
Wan-Qiu Liu ◽  
Youli Jia ◽  
Yongzhen Li ◽  
Wilfred A. van der Donk ◽  
...  
Keyword(s):  
Natural Products ◽  
Biological Activities ◽  
Genome Mining ◽  
Substrate Specificities ◽  
Modified Peptides ◽  
Fungal Natural Products ◽  
Different Strains

Production of ribosomally synthesized and posttranslationally modified peptides (RiPPs) has rarely been reported in fungi, even though organisms of this kingdom have a long history as a prolific source of natural products. Here we report an investigation of the phomopsins, antimitotic mycotoxins. We show that phomopsin is a fungal RiPP and demonstrate the widespread presence of a pathway for the biosynthesis of a family of fungal cyclic RiPPs, which we term dikaritins. We characterize PhomM as an S-adenosylmethionine–dependent α-N-methyltransferase that converts phomopsin A to anN,N-dimethylated congener (phomopsin E), and show that the methyltransferases involved in dikaritin biosynthesis have evolved differently and likely have broad substrate specificities. Genome mining studies identified eight previously unknown dikaritins in different strains, highlighting the untapped capacity of RiPP biosynthesis in fungi and setting the stage for investigating the biological activities and unknown biosynthetic transformations of this family of fungal natural products.

Computational Studies on the Substrate Specificity of an Acyltransferase Domain from Salinomycin Polyketide Synthase

2021 ◽  
Author(s):  
Huining Ji ◽  
Ting Shi ◽  
Lei Liu ◽  
Fa Zhang ◽  
Wentao Tao ◽  
...  
Keyword(s):  
Natural Products ◽  
Substrate Specificity ◽  
Polyketide Synthase ◽  
Coenzyme A ◽  
Biological Activities ◽  
Polyketide Synthases ◽  
Short Chain ◽  
Computational Studies ◽  
Chemical Structures ◽  
Coa Thioesters

Polyketides are a large group of natural products with diverse chemical structures and biological activities. They are biosynthesized by modular polyketide synthases (PKSs) from coenzyme A (CoA) thioesters of short-chain...

Total syntheses of spirocyclic PKS-NRPS-based fungal metabolites

2018 ◽  
Vol 54 (50) ◽  
pp. 6750-6758 ◽  
Author(s):  
Deokhee Jo ◽  
Sunkyu Han
Keyword(s):  
Natural Products ◽  
Biological Activities ◽  
Fungal Metabolites ◽  
Comprehensive Description ◽  
Total Syntheses ◽  
Fungal Natural Products ◽  
Biosynthetic Studies

We present the isolations, the biosynthetic studies, the biological activities, and the comprehensive description of all reported total syntheses of spirocyclic PKS-NRPS-based fungal natural products.

scholarly journals Unveiling sequential late-stage methyltransferase reactions in the meleagrin/oxaline biosynthetic pathway

2018 ◽  
Vol 16 (35) ◽  
pp. 6450-6459 ◽  
Author(s):  
Sean A. Newmister ◽  
Stelamar Romminger ◽  
Jennifer J. Schmidt ◽  
Robert M. Williams ◽  
Janet L. Smith ◽  
...  
Keyword(s):  
Natural Products ◽  
Enzymatic Activity ◽  
Crystal Structures ◽  
Late Stage ◽  
Biosynthetic Pathway ◽  
Fungal Natural Products

Enzymatic activity and crystal structures of the methyltransferases involved in the biosynthesis of fungal natural products meleagrin and oxaline.

Fungal natural products targeting chronic lymphocytic leukemia

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
T Thorskov Bladt ◽  
S Kildgaard ◽  
P Boldsen Knudsen ◽  
C Held Gotfredsen ◽  
C Dürr ◽  
...  
Keyword(s):  
Natural Products ◽  
Chronic Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Fungal Natural Products

Pyrone-derived Marine Natural Products: A Review on Isolation, Bio-activities and Synthesis

2020 ◽  
Vol 24 (4) ◽  
pp. 354-401 ◽  
Author(s):  
Keisham S. Singh
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Marine Fungi ◽  
Kojic Acid ◽  
Biological Activities ◽  
Biological Significance ◽  
Pyrone Ring ◽  
Enol Ethers ◽  
Bioactive Natural Products ◽  
Marine Metabolites

Marine natural products (MNPs) containing pyrone rings have been isolated from numerous marine organisms, and also produced by marine fungi and bacteria, particularly, actinomycetes. They constitute a versatile structure unit of bioactive natural products that exhibit various biological activities such as antibiotic, antifungal, cytotoxic, neurotoxic, phytotoxic and anti-tyrosinase. The two structure isomers of pyrone ring are γ- pyrone and α-pyrone. In terms of chemical motif, γ-pyrone is the vinologous form of α- pyrone which possesses a lactone ring. Actinomycete bacteria are responsible for the production of several α-pyrone compounds such as elijopyrones A-D, salinipyrones and violapyrones etc. to name a few. A class of pyrone metabolites, polypropionates which have fascinating carbon skeleton, is primarily produced by marine molluscs. Interestingly, some of the pyrone polytketides which are found in cone snails are actually synthesized by actinomycete bacteria. Several pyrone derivatives have been obtained from marine fungi such as Aspergillums flavus, Altenaria sp., etc. The γ-pyrone derivative namely, kojic acid obtained from Aspergillus fungus has high commercial demand and finds various applications. Kojic acid and its derivative displayed inhibition of tyrosinase activity and, it is also extensively used as a ligand in coordination chemistry. Owing to their commercial and biological significance, the synthesis of pyrone containing compounds has been given attention over the past years. Few reviews on the total synthesis of pyrone containing natural products namely, polypropionate metabolites have been reported. However, these reviews skipped other marine pyrone metabolites and also omitted discussion on isolation and detailed biological activities. This review presents a brief account of the isolation of marine metabolites containing a pyrone ring and their reported bio-activities. Further, the review covers the synthesis of marine pyrone metabolites such as cyercene-A, placidenes, onchitriol-I, onchitriol-II, crispatene, photodeoxytrichidione, (-) membrenone-C, lihualide-B, macrocyclic enol ethers and auripyrones-A & B.

scholarly journals Natural products isolated from Casimiroa

2020 ◽  
Vol 18 (1) ◽  
pp. 778-797
Author(s):  
Khun Nay Win Tun ◽  
Nanik Siti Aminah ◽  
Alfinda Novi Kristanti ◽  
Hnin Thanda Aung ◽  
Yoshiaki Takaya
Keyword(s):  
Natural Products ◽  
Spectral Data ◽  
Aromatic Compounds ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Quinoline Alkaloids

AbstractAbout 140 genera and more than 1,600 species belong to the Rutaceae family. They grow in temperate and tropical zones on both hemispheres, as trees, shrubs, and herbs. Casimiroa is one of the genera constituting 13 species, most of which are found in tropical and subtropical regions. Many chemical constituents have been derived from this genus, including quinoline alkaloids, flavonoids, coumarins, and N-benzoyltyramide derivatives. This article reviews different studies carried out on aromatic compounds of genus Casimiroa; their biological activities; the different skeletons of coumarins, alkaloids, flavonoids, and others; and their characteristic NMR spectral data.

scholarly journals Core Steps to the Azaphilone Family of Fungal Natural Products

ChemBioChem ◽  
2021 ◽  
Author(s):  
Katherine Williams ◽  
Claudio Greco ◽  
Andrew M. Bailey ◽  
Christine L. Willis
Keyword(s):  
Natural Products ◽  
Fungal Natural Products
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