Adamantane amine derivatives as dual acting NMDA receptor and voltage-gated calcium channel inhibitors for neuroprotection

Yakub E. Kadernani; Frank T. Zindo; Erika Kapp; Sarel F. Malan; Jacques Joubert

doi:10.1039/c4md00244j

Adamantane amine derivatives as dual acting NMDA receptor and voltage-gated calcium channel inhibitors for neuroprotection

MedChemComm ◽

10.1039/c4md00244j ◽

2014 ◽

Vol 5 (11) ◽

pp. 1678-1684 ◽

Cited By ~ 7

Author(s):

Yakub E. Kadernani ◽

Frank T. Zindo ◽

Erika Kapp ◽

Sarel F. Malan ◽

Jacques Joubert

Keyword(s):

Nmda Receptor ◽

Calcium Channel ◽

Voltage Gated ◽

Inhibitory Activities ◽

Calcium Channel Inhibitors ◽

Voltage Gated Calcium Channel

A series of adamantane-derived compounds, structurally similar to NGP1-01, were synthesised and showed significant dual NMDA receptor and VGCC inhibitory activities.

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Alteration in the phosphorylation status of NMDA receptor GluN2B subunit by activation of both NMDA receptor and L-type voltage gated calcium channel

Neuroscience Letters ◽

10.1016/j.neulet.2019.134343 ◽

2019 ◽

Vol 709 ◽

pp. 134343

Author(s):

Mantosh Kumar ◽

Mathew John ◽

Mayadevi Madhavan ◽

Jackson James ◽

Ramakrishnapillai V. Omkumar

Keyword(s):

Nmda Receptor ◽

Calcium Channel ◽

Voltage Gated ◽

Voltage Gated Calcium Channel

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Tricycloundecane Derivatives as PotentialN-Methyl-D-aspartate (NMDA) Receptor and Voltage-Gated Calcium Channel Modulators

ChemMedChem ◽

10.1002/cmdc.201500072 ◽

2015 ◽

Vol 10 (7) ◽

pp. 1259-1266 ◽

Cited By ~ 5

Author(s):

Ayodeji O. Egunlusi ◽

Sarel F. Malan ◽

Jacques Joubert

Keyword(s):

Nmda Receptor ◽

Calcium Channel ◽

Voltage Gated ◽

Voltage Gated Calcium Channel

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L-type voltage-gated calcium channel attends regulation of tyrosine phosphorylation of NMDA receptor subunit 2A induced by transient brain ischemia

Brain Research ◽

10.1016/s0006-8993(03)02519-8 ◽

2003 ◽

Vol 972 (1-2) ◽

pp. 142-148 ◽

Cited By ~ 16

Author(s):

Yong Liu ◽

Xiao-Yu Hou ◽

Guang-Yi Zhang ◽

Tian-Le Xu

Keyword(s):

Nmda Receptor ◽

Calcium Channel ◽

Tyrosine Phosphorylation ◽

Brain Ischemia ◽

Receptor Subunit ◽

Nmda Receptor Subunit ◽

Voltage Gated ◽

Voltage Gated Calcium Channel

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Development and validation of an LC–MS/MS method for determination of the L-type voltage-gated calcium channel/NMDA receptor antagonist NGP1-01 in mouse serum

Journal of Chromatography B ◽

10.1016/j.jchromb.2014.05.048 ◽

2014 ◽

Vol 963 ◽

pp. 83-89 ◽

Cited By ~ 2

Author(s):

Harini Jogiraju ◽

Xiang Zhou ◽

Ashta Lakshmi Prasad Gobburi ◽

Kiran K. Pedada ◽

Werner J. Geldenhuys ◽

...

Keyword(s):

Nmda Receptor ◽

Calcium Channel ◽

Receptor Antagonist ◽

Nmda Receptor Antagonist ◽

Mouse Serum ◽

Voltage Gated ◽

Voltage Gated Calcium Channel ◽

Development And Validation

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Voltage-Gated calcium channel currents in pregnant human myometrial smooth muscle cells and their inhibition by iniomethacin

Journal of the Society for Gynecologic Investigation ◽

10.1016/s1071-5576(97)86673-7 ◽

1998 ◽

Vol 5 (1) ◽

pp. 185A-185A

Author(s):

G KNOCK ◽

S SMIRNOV ◽

P AARONSON

Keyword(s):

Smooth Muscle ◽

Smooth Muscle Cells ◽

Calcium Channel ◽

Muscle Cells ◽

Voltage Gated ◽

Voltage Gated Calcium Channel ◽

Channel Currents

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The L-type voltage-gated calcium channel CaV1.2 α1 subunit in activated reactive astrocytes around β-amyloid plaques in an Alzheimer mouse model

Intrinsic Activity ◽

10.25006/ia.1.s1-a2.1 ◽

2013 ◽

Vol 1 (Suppl. 1) ◽

pp. A2.1

Author(s):

Nina Daschil

Keyword(s):

Mouse Model ◽

Calcium Channel ◽

Amyloid Plaques ◽

Reactive Astrocytes ◽

Voltage Gated ◽

Β Amyloid ◽

Voltage Gated Calcium Channel ◽

Α1 Subunit

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Faculty Opinions recommendation of The C terminus of the L-type voltage-gated calcium channel Ca(V)1.2 encodes a transcription factor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1050621.518712 ◽

2007 ◽

Author(s):

Donald Bers

Keyword(s):

Transcription Factor ◽

Calcium Channel ◽

Voltage Gated ◽

C Terminus ◽

Voltage Gated Calcium Channel

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Faculty Opinions recommendation of BARP suppresses voltage-gated calcium channel activity and Ca2+-evoked exocytosis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718358255.793494421 ◽

2014 ◽

Author(s):

Geneviève Dupont

Keyword(s):

Calcium Channel ◽

Channel Activity ◽

Voltage Gated ◽

Voltage Gated Calcium Channel

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Faculty Opinions recommendation of Structure of the voltage-gated calcium channel Ca(v)1.1 at 3.6 Å resolution.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726697870.793553027 ◽

2018 ◽

Author(s):

Annette Dolphin

Keyword(s):

Calcium Channel ◽

Voltage Gated ◽

Voltage Gated Calcium Channel

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Faculty Opinions recommendation of Alcohol Dependence Disrupts Amygdalar L-Type Voltage-Gated Calcium Channel Mechanisms.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727467401.793531479 ◽

2017 ◽

Author(s):

Robert Peoples

Keyword(s):

Alcohol Dependence ◽

Calcium Channel ◽

Voltage Gated ◽

Voltage Gated Calcium Channel

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