Stabilization for loop isomers of c-myc G-quadruplex DNA and anticancer activity by ruthenium complexes

MedChemComm ◽  
2014 ◽  
Vol 5 (11) ◽  
pp. 1724-1728 ◽  
Author(s):  
Ying Liu ◽  
Yanan Liu ◽  
Licong Yang ◽  
Chengwen Cao ◽  
Yanhui Zhou ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Ruthenium Complexes ◽  
Quadruplex Dna ◽  
G Quadruplex

A comparative study of the interaction of two structurally analogous ruthenium complexes with human telomeric G-quadruplex DNA

2013 ◽  
Vol 121 ◽  
pp. 19-27 ◽  
Author(s):  
Shuo Shi ◽  
Hai-Liang Huang ◽  
Xing Gao ◽  
Jun-Liang Yao ◽  
Chun-Yan Lv ◽  
...  
Keyword(s):  
Comparative Study ◽  
Ruthenium Complexes ◽  
Quadruplex Dna ◽  
G Quadruplex

scholarly journals Benzimidazole-1,2,3-triazole hybrid molecules: synthesis and study of their interaction with G-quadruplex DNA

2021 ◽  
Author(s):  
Padma S. Singu ◽  
Ushasri Chilakamarthi ◽  
Namita S. Mahadik ◽  
Bhamidipati Keerti ◽  
Narasimhulu Valipenta ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Anticancer Activity ◽  
Duplex Dna ◽  
Quadruplex Dna ◽  
Hybrid Molecules ◽  
G Quadruplex ◽  
M Phase

The benzimidazole-1,2,3-triazole hybrid 4f selectively interacted with G-quadruplex DNA over duplex DNA, inhibits cell cycle at the G2/M phase, inducing apoptosis, and may be a G-quadruplex DNA groove binder with anticancer activity.

New 2,9-disubstituted-1,10-phenanthroline derivatives with anticancer activity by selective targeting of telomeric G-quadruplex DNA

2021 ◽  
Vol 249 ◽  
pp. 119318
Author(s):  
Anda-Mihaela Craciun ◽  
Alexandru Rotaru ◽  
Corneliu Cojocaru ◽  
Ionel I. Mangalagiu ◽  
Ramona Danac
Keyword(s):  
Anticancer Activity ◽  
Quadruplex Dna ◽  
Selective Targeting ◽  
G Quadruplex

Two structurally analogous ruthenium complexes as naked-eye and reversible molecular “light switch” for G-quadruplex DNA

2014 ◽  
Vol 140 ◽  
pp. 64-71 ◽  
Author(s):  
Xiao-Hui Lu ◽  
Shuo Shi ◽  
Jun-Liang Yao ◽  
Xing Gao ◽  
Hai-Liang Huang ◽  
...  
Keyword(s):  
Ruthenium Complexes ◽  
Quadruplex Dna ◽  
Naked Eye ◽  
G Quadruplex ◽  
Molecular Light Switch

Hybrid Imidazole-Pyridine Derivatives: An Approach to Novel Anticancer DNA Intercalators

2020 ◽  
Vol 27 (1) ◽  
pp. 154-169 ◽  
Author(s):  
Claudiu N. Lungu ◽  
Bogdan Ionel Bratanovici ◽  
Maria Mirabela Grigore ◽  
Vasilichia Antoci ◽  
Ionel I. Mangalagiu
Keyword(s):  
Experimental Data ◽  
Antimicrobial Properties ◽  
Qsar Model ◽  
Therapeutic Effectiveness ◽  
Computational Results ◽  
Pyridine Derivatives ◽  
Quadruplex Dna ◽  
Dna Intercalators ◽  
Structure Activity ◽  
G Quadruplex

Lack of specificity and subsequent therapeutic effectiveness of antimicrobial and antitumoral drugs is a common difficulty in therapy. The aim of this study is to investigate, both by experimental and computational methods, the antitumoral and antimicrobial properties of a series of synthesized imidazole-pyridine derivatives. Interaction with three targets was discussed: Dickerson-Drew dodecamer (PDB id 2ADU), G-quadruplex DNA string (PDB id 2F8U) and DNA strain in complex with dioxygenase (PDB id 3S5A). Docking energies were computed and represented graphically. On them, a QSAR model was developed in order to further investigate the structure-activity relationship. Results showed that synthesized compounds have antitumoral and antimicrobial properties. Computational results agreed with the experimental data.

Emerging Role of G-quadruplex DNA as Target in Anticancer Therapy

2017 ◽  
Vol 22 (44) ◽  
pp. 6612-6624 ◽  
Author(s):  
Graziella Cimino-Reale ◽  
Nadia Zaffaroni ◽  
Marco Folini
Keyword(s):  
Anticancer Therapy ◽  
Quadruplex Dna ◽  
G Quadruplex
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