Synthesis and evaluation of a series of quinolinyl trans-cyanostilbene analogs as anticancer agents

MedChemComm ◽  
2014 ◽  
Vol 5 (7) ◽  
pp. 886-890 ◽  
Author(s):  
Narsimha Reddy Penthala ◽  
Venumadhav Janganati ◽  
Shobanbabu Bommagani ◽  
Peter A. Crooks
Keyword(s):  
Growth Inhibition ◽  
Cell Lines ◽  
Cancer Cell ◽  
Anticancer Agents ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Potent Growth

2-Quinolyl- and 3-quinolyl-cyanocombretastatin analogs exhibit potent growth inhibition against a panel of 60 human cancer cell lines.

scholarly journals Cytotoxic Effects of Topotecan Combined With Various Anticancer Agents in Human Cancer Cell Lines

1996 ◽  
Vol 88 (11) ◽  
pp. 734-741 ◽  
Author(s):  
Scott H. Kaufmann ◽  
David Peereboom ◽  
Christopher A. Buckwalter ◽  
Phyllis A. Svingen ◽  
Louise B. Grochow ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Anticancer Agents ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Cytotoxic Effects ◽  
Human Cancer Cell Lines

Comparative studies of adriamycin and 28-Deacetyl sendanin onin vitro growth inhibition of human cancer cell lines

1994 ◽  
Vol 17 (2) ◽  
pp. 100-103 ◽  
Author(s):  
Hwan Mook Kim ◽  
Goo Taeg Oh ◽  
Sang Bae Han ◽  
Dong Ho Hong ◽  
Bang Yeon Hwang ◽  
...  
Keyword(s):  
Growth Inhibition ◽  
Cell Lines ◽  
Cancer Cell ◽  
Comparative Studies ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines

scholarly journals Human cancer cell lines growth inhibition by GTn oligodeoxyribonucleotides recognizing single-stranded DNA-binding proteins

1998 ◽  
Vol 252 (2) ◽  
pp. 207-215 ◽  
Author(s):  
Bruna Scaggiante ◽  
Carla Morassutti ◽  
Barbara Dapas ◽  
Giuseppe Tolazzi ◽  
Franca Ustulin ◽  
...  
Keyword(s):  
Dna Binding ◽  
Growth Inhibition ◽  
Cell Lines ◽  
Cancer Cell ◽  
Binding Proteins ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Dna Binding Proteins ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines

Synthesis of imidazo[2,1-b][1,3,4]thiadiazole–chalcones as apoptosis inducing anticancer agents

MedChemComm ◽  
2014 ◽  
Vol 5 (11) ◽  
pp. 1718-1723 ◽  
Author(s):  
Ahmed Kamal ◽  
Vangala Santhosh Reddy ◽  
Karnewar Santosh ◽  
G. Bharath Kumar ◽  
Anver Basha Shaik ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Anticancer Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Anticancer Agents ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines

A library of imidazothiadiazole–chalcone conjugates were synthesised and investigated for their cytotoxic activity against various human cancer cell lines. Some of the tested compounds like 7a, 7b, 11a and 11b exhibited promising anticancer activity.

scholarly journals Modulating the activity of short arginine-tryptophan containing antibacterial peptides with N-terminal metallocenoyl groups

2012 ◽  
Vol 8 ◽  
pp. 1753-1764 ◽  
Author(s):  
H Bauke Albada ◽  
Alina-Iulia Chiriac ◽  
Michaela Wenzel ◽  
Maya Penkova ◽  
Julia E Bandow ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Growth Inhibition ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Inhibition Studies ◽  
Kinetics Of

A series of small synthetic arginine and tryptophan containing peptides was prepared and analyzed for their antibacterial activity. The effect of N-terminal substitution with metallocenoyl groups such as ferrocene (FcCO) and ruthenocene (RcCO) was investigated. Antibacterial activity in different media, growth inhibition, and killing kinetics of the most active peptides were determined. The toxicity of selected derivatives was determined against erythrocytes and three human cancer cell lines. It was shown that the replacement of an N-terminal arginine residue with a metallocenoyl moiety modulates the activity of WRWRW-peptides against Gram-positive and Gram-negative bacteria. MIC values of 2–6 µM for RcCO-W(RW)2 and 1–11 µM for (RW)3 were determined. Interestingly, W(RW)2-peptides derivatized with ferrocene were significantly less active than those derivatized with ruthenocene which have similar structural but different electronic properties, suggesting a major influence of the latter. The high activities observed for the RcCO-W(RW)2- and (RW)3-peptides led to an investigation of the origin of activity of these peptides using several important activity-related parameters. Firstly, killing kinetics of the RcCO-W(RW)2-peptide versus killing kinetics of the (RW)3 derivative showed faster reduction of the colony forming units for the RcCO-W(RW)2-peptide, although MIC values indicated higher activity for the (RW)3-peptide. This was confirmed by growth inhibition studies. Secondly, hemolysis studies revealed that both peptides did not lead to significant destruction of erythrocytes, even up to 500 µg/mL for (RW)3 and 250 µg/mL for RcCO-W(RW)2. In addition, toxicity against three human cancer cell lines (HepG2, HT29, MCF7) showed that the (RW)3-peptide had an IC50 value of ~140 µM and the RcW(RW)2 one of ~90 µM, indicating a potentially interesting therapeutic window. Both the killing kinetics and growth inhibition studies presented in this work point to a membrane-based mode of action for these two peptides, each having different kinetic parameters.

Copper(ii) complexes based on tripodal pyridyl amine derivatives as efficient anticancer agents

2019 ◽  
Vol 43 (16) ◽  
pp. 6186-6196 ◽  
Author(s):  
Salah S. Massoud ◽  
Febee R. Louka ◽  
Ada F. Tusa ◽  
Nicole E. Bordelon ◽  
Roland C. Fischer ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Anticancer Agents ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines

The in vitro cytotoxicity of a series of chlorido-Cu(ii) complexes based on tripod pyridyl N4-donor derivatives revealed significant-to-moderate cytotoxicity against human cancer cell lines with the best results obtained for [Cu(BQPA)Cl]ClO4/PF6 (5-ClO4/PF6) with IC50 values of 4.7–10.8 μM.

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