scholarly journals Repurposing human Aurora kinase inhibitors as leads for anti-protozoan drug discovery

MedChemComm ◽  
2014 ◽  
Vol 5 (5) ◽  
pp. 655-658 ◽  
Author(s):  
Gautam Patel ◽  
Norma E. Roncal ◽  
Patricia J. Lee ◽  
Susan E. Leed ◽  
Jessey Erath ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Drug Discovery ◽  
Trypanosoma Brucei ◽  
Leishmania Major ◽  
Kinase Inhibitors ◽  
Aurora Kinase ◽  
Aurora B ◽  
Aurora Kinase Inhibitors

Hesperadin, an established human Aurora B inhibitor, was tested against cultures of Trypanosoma brucei, Leishmania major, and Plasmodium falciparum, and was identified to be a potent proliferation inhibitor.

scholarly journals Inhibition of Aurora A and Aurora B Is Required for the Sensitivity of HPV-Driven Cervical Cancers to Aurora Kinase Inhibitors

2017 ◽  
Vol 16 (9) ◽  
pp. 1934-1941 ◽  
Author(s):  
David Martin ◽  
Sora Fallaha ◽  
Martina Proctor ◽  
Alexander Stevenson ◽  
Lewis Perrin ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
Aurora Kinase ◽  
Aurora B ◽  
Aurora A ◽  
Cervical Cancers ◽  
Aurora Kinase Inhibitors

scholarly journals Aurora B kinase inhibition in mitosis: Strategies for optimizing the use of Aurora kinase inhibitors such as AT9283

Cell Cycle ◽  
2009 ◽  
Vol 8 (12) ◽  
pp. 1921-1929 ◽  
Author(s):  
Jayne Curry ◽  
Hayley Angove ◽  
Lynsey Fazal ◽  
John Lyons ◽  
Matthias Reule ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
Aurora Kinase ◽  
Aurora B ◽  
Aurora B Kinase ◽  
Kinase Inhibition ◽  
Aurora Kinase Inhibitors

Aurora Kinase Inhibitors in Head and Neck Cancer

2018 ◽  
Vol 18 (3) ◽  
pp. 199-213
Author(s):  
Guangying Qi ◽  
Jing Liu ◽  
Sisi Mi ◽  
Takaaki Tsunematsu ◽  
Shengjian Jin ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Cancer Therapy ◽  
Kinase Inhibitors ◽  
Biological Function ◽  
Aurora Kinase ◽  
Aurora Kinases ◽  
Related Research ◽  
Chemotherapy Drugs ◽  
Aurora Kinase Inhibitors

Aurora kinases are a group of serine/threonine kinases responsible for the regulation of mitosis. In recent years, with the increase in Aurora kinase-related research, the important role of Aurora kinases in tumorigenesis has been gradually recognized. Aurora kinases have been regarded as a new target for cancer therapy, resulting in the development of Aurora kinase inhibitors. The study and application of these small-molecule inhibitors, especially in combination with chemotherapy drugs, represent a new direction in cancer treatment. This paper reviews studies on Aurora kinases from recent years, including studies of their biological function, their relationship with tumor progression, and their inhibitors.

Discovery of novel 2,4-disubstituted pyrimidines as Aurora kinase inhibitors

2020 ◽  
Vol 30 (3) ◽  
pp. 126885 ◽  
Author(s):  
Yu Xu ◽  
Shu-Yi Hao ◽  
Xiu-Juan Zhang ◽  
Wen-Bo Li ◽  
Xue-Peng Qiao ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
Aurora Kinase ◽  
Aurora Kinase Inhibitors

Aurora Kinase Inhibitors

2007 ◽  
pp. 157-175
Author(s):  
Mitesh Borad ◽  
Steven Warner ◽  
Daniel Von Hoff
Keyword(s):  
Kinase Inhibitors ◽  
Aurora Kinase ◽  
Aurora Kinase Inhibitors
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