Metabonomic analysis of the therapeutic effect of Potentilla discolor in the treatment of type 2 diabetes mellitus

2014 ◽  
Vol 10 (11) ◽  
pp. 2898-2906 ◽  
Author(s):  
Yi Li ◽  
Jing-jing Li ◽  
Xiao-dong Wen ◽  
Rong Pan ◽  
Yi-sheng He ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Therapeutic Effect ◽  
Corosolic Acid

A plasma metabonomic approach was applied to investigate the effects of P. discolor and corosolic acid.

scholarly journals The Influence of Hyperglycemia on the Therapeutic Effect of Exercise on Glycemic Control in Patients With Type 2 Diabetes Mellitus

2013 ◽  
Vol 173 (19) ◽  
pp. 1834 ◽  
Author(s):  
Thomas P. J. Solomon ◽  
Steven K. Malin ◽  
Kristian Karstoft ◽  
Jacob M. Haus ◽  
John P. Kirwan
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Therapeutic Effect

Development of FABP4/5 inhibitors with potential therapeutic effect on type 2 Diabetes Mellitus

2021 ◽  
pp. 113720
Author(s):  
Yu-Long He ◽  
Meng-Ting Chen ◽  
Ting Wang ◽  
Ming-Ming Zhang ◽  
Ying-Xia Li ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Therapeutic Effect

scholarly journals Melatonin Promotes the Therapeutic Effect of Mesenchymal Stem Cells on Type 2 Diabetes Mellitus by Regulating TGF-β Pathway

2021 ◽  
Vol 9 ◽  
Author(s):  
Balun Li ◽  
Xuedi Cheng ◽  
Aili Aierken ◽  
Jiaxin Du ◽  
Wenlai He ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Type 2 Diabetes Mellitus ◽  
Therapeutic Effect ◽  
Culture Medium ◽  
Transforming Growth Factor

Abundant evidence proves the therapeutic effect of adipose-derived mesenchymal stem cells (ADMSCs) in the treatment of diabetes mellitus. However, the problems have not been solved that viability of ADMSCs were inconsistent and the cells quickly undergo senescence after in vitro cell culture. In addition, the therapeutic effect of ADMSCs is still not satisfactory. In this study, melatonin (MLT) was added to canine ADMSC culture medium, and the treated cells were used to treat type 2 diabetes mellitus (T2DM). Our research reveals that adding MLT to ADMSC culture medium can promote the viability of ADMSCs. This effect depends on the binding of MLT and MLT receptors, which activates the transforming growth factor β (TGF-β) pathway and then changes the cell cycle of ADMSCs and improves the viability of ADMSCs. Since ADMSCs were found to be used to treat T2DM by anti-inflammatory and anti-endoplasmic reticulum (ER) stress capabilities, our data demonstrate that MLT augment several effects of ADMSCs in remission hyperglycemia, insulin resistance, and liver glycogen metabolism in T2DM patients. This suggest that ADMSCs and MLT-ADMSCs is safe and vabulable for pet clinic.

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