Finger-powered microfluidic systems using multilayer soft lithography and injection molding processes

Lab on a Chip ◽  
2014 ◽  
Vol 14 (19) ◽  
pp. 3790 ◽  
Author(s):  
Kosuke Iwai ◽  
Kuan Cheng Shih ◽  
Xiao Lin ◽  
Thomas A. Brubaker ◽  
Ryan D. Sochol ◽  
...  
Keyword(s):  
Injection Molding ◽  
Soft Lithography ◽  
Microfluidic Systems ◽  
Multilayer Soft Lithography

scholarly journals Advanced Fabrication Techniques of Microengineered Physiological Systems

Micromachines ◽  
2020 ◽  
Vol 11 (8) ◽  
pp. 730
Author(s):  
Joseph R. Puryear III ◽  
Jeong-Kee Yoon ◽  
YongTae Kim
Keyword(s):  
3D Printing ◽  
Injection Molding ◽  
Soft Lithography ◽  
Great Promise ◽  
Limiting Factor ◽  
Precision Engineering ◽  
Advantages And Disadvantages ◽  
Geometric Conditions ◽  
Physiological Systems ◽  
The Way

The field of organs-on-chips (OOCs) has experienced tremendous growth over the last decade. However, the current main limiting factor for further growth lies in the fabrication techniques utilized to reproducibly create multiscale and multifunctional devices. Conventional methods of photolithography and etching remain less useful to complex geometric conditions with high precision needed to manufacture the devices, while laser-induced methods have become an alternative for higher precision engineering yet remain costly. Meanwhile, soft lithography has become the foundation upon which OOCs are fabricated and newer methods including 3D printing and injection molding show great promise to innovate the way OOCs are fabricated. This review is focused on the advantages and disadvantages associated with the commonly used fabrication techniques applied to these microengineered physiological systems (MPS) and the obstacles that remain in the way of further innovation in the field.

scholarly journals The microfluidic laboratory at Synchrotron SOLEIL

2020 ◽  
Vol 27 (1) ◽  
pp. 230-237
Author(s):  
Igor Chaussavoine ◽  
Anthony Beauvois ◽  
Tiphaine Mateo ◽  
Ramakrishna Vasireddi ◽  
Nadine Douri ◽  
...  
Keyword(s):  
Soft Lithography ◽  
Light Sources ◽  
Microfluidic Chips ◽  
Liquid Sample ◽  
Microfluidic Systems ◽  
Time Resolved ◽  
Liquid Environment ◽  
X Ray ◽  
Physical Chemical ◽  
Biological Phenomena

A microfluidic laboratory recently opened at Synchrotron SOLEIL, dedicated to in-house research and external users. Its purpose is to provide the equipment and expertise that allow the development of microfluidic systems adapted to the beamlines of SOLEIL as well as other light sources. Such systems can be used to continuously deliver a liquid sample under a photon beam, keep a solid sample in a liquid environment or provide a means to track a chemical reaction in a time-resolved manner. The laboratory provides all the amenities required for the design and preparation of soft-lithography microfluidic chips compatible with synchrotron-based experiments. Three examples of microfluidic systems that were used on SOLEIL beamlines are presented, which allow the use of X-ray techniques to study physical, chemical or biological phenomena.

scholarly journals Centrifugal Casting of Microfluidic Components With PDMS

2013 ◽  
Vol 1 (2) ◽  
Author(s):  
Aaron D. Mazzeo ◽  
David E. Hardt
Keyword(s):  
Coefficient Of Variation ◽  
Soft Lithography ◽  
Centrifugal Casting ◽  
Microfluidic Channels ◽  
Active Elements ◽  
Axis Of Rotation ◽  
Multilayer Soft Lithography

This work describes the centrifugal casting and fast curing of double-sided, polydimethylsiloxane (PDMS)-based components with microfeatures. Centrifugal casting permits simultaneous patterning of multiple sides of a component and allows control of the thickness of the part in an enclosed mold without entrapment of bubbles. Spinning molds filled with PDMS at thousands of revolutions per minute for several minutes causes entrapped bubbles within the PDMS to migrate toward the axis of rotation or dissolve into solution. To cure the parts quickly (<10 min), active elements heat and cool cavities filled with PDMS after the completion of spinning. Microfluidic channels produced from the process have a low coefficient of variation (<2% for the height and width of channels measured in 20 parts). This process is also capable of molding functional channels in opposite sides of a part as demonstrated through a device with a system of valves typical to multilayer soft lithography.

A Plastic Micro Injection Molding Technique Using Replaceable Mold-Disks for Disposable Microfluidic Systems and Biochips

2001 ◽  
pp. 411-412 ◽  
Author(s):  
Jin-Woo Choi ◽  
Sanghyo Kim ◽  
Ramachandran Trichur ◽  
Hyoung J. Cho ◽  
Aniruddha Puntambekar ◽  
...  
Keyword(s):  
Injection Molding ◽  
Microfluidic Systems ◽  
Micro Injection Molding

Latchable Phase-Change Actuators for Micro Flow Control Applications

2005 ◽  
Author(s):  
Bozhi Yang ◽  
Qiao Lin
Keyword(s):  
Phase Change ◽  
Soft Lithography ◽  
Phase Changes ◽  
Minimal Energy ◽  
Control Applications ◽  
Micro Flow ◽  
Flow Through ◽  
Multilayer Soft Lithography ◽  
Solid Liquid ◽  
Lithography Technique

This paper presents a novel latchable phase-change actuator that can potentially be used for flow valving and gating in portable lab-on-a-chip systems, where minimal energy consumption is required. The actuator exploits a low melting-point paraffin wax, whose solid-liquid phase changes allow the closing and opening of fluid flow through deformable microchannels. Flow switching is initiated by melting of paraffin, with an additional pneumatic pressure required for flow switching from open to closed state. After paraffin solidifies the switched state is subsequently maintained passively without further consumption of energy. The actuator can be fabricated from PDMS through the multilayer soft lithography technique. Testing results demonstrate that the actuator has a response time about 60-100 sec for flow switching, and can passively hold a microvalve closed under pressures up to 35 kPa.

scholarly journals On-ratio PDMS bonding for multilayer microfluidic device fabrication

2018 ◽  
Author(s):  
Andre Lai ◽  
Nicolas Altemose ◽  
Jonathan A. White ◽  
Aaron M. Streets
Keyword(s):  
Conventional Method ◽  
Material Properties ◽  
Soft Lithography ◽  
Crosslinking Agent ◽  
Microfluidic Devices ◽  
Device Fabrication ◽  
Common Variants ◽  
Precise Control ◽  
Multilayer Soft Lithography ◽  
Bonding Technique

AbstractIntegrated elastomeric valves, also referred to as Quake valves, enable precise control and manipulation of fluid within microfluidic devices. Fabrication of such valves requires bonding of multiple layers of the silicone polymer polydimethylsiloxane (PDMS). The conventional method for PDMS-PDMS bonding is to use varied base to crosslinking agent ratios between layers, typically 20:1 and 5:1. This bonding technique, known as “off-ratio bonding,” provides strong, effective PDMS-PDMS bonding for multi-layer soft-lithography, but it can yield adverse PDMS material properties and can be wasteful of PDMS. Here we demonstrate the effectiveness of on-ratio PDMS bonding for multilayer soft lithography. We show the efficacy of this technique among common variants of PDMS: Sylgard 184, RTV 615, and Sylgard 182.

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