Enabling practical surface acoustic wave nebulizer drug delivery via amplitude modulation

Lab on a Chip ◽  
2014 ◽  
Vol 14 (11) ◽  
pp. 1858-1865 ◽  
Author(s):  
Anushi Rajapaksa ◽  
Aisha Qi ◽  
Leslie Y. Yeo ◽  
Ross Coppel ◽  
James R. Friend
Keyword(s):  
Drug Delivery ◽  
Acoustic Wave ◽  
Surface Acoustic Wave ◽  
Microfluidic Device ◽  
Amplitude Modulation ◽  
Power Supply

A practical, commercially viable microfluidic device relies upon the miniaturization and integration of all its components—including pumps, circuitry, and power supply—onto a chip-based platform.

Surface acoustic wave microfluidic device

2006 ◽  
Author(s):  
D. Beyssen ◽  
L. Le Brizoual ◽  
O. Elmazria ◽  
P. Alnot
Keyword(s):  
Acoustic Wave ◽  
Surface Acoustic Wave ◽  
Microfluidic Device

A paper-based microfluidic device with surface acoustic wave integrated in a printed circuit board

2016 ◽  
Vol 504 (1) ◽  
pp. 230-236
Author(s):  
Liang-Wei Dong ◽  
Yue-Li Hu ◽  
Yi-Feng Han ◽  
An-Liang Zhang ◽  
Xiang-Ting Fu
Keyword(s):  
Acoustic Wave ◽  
Surface Acoustic Wave ◽  
Microfluidic Device ◽  
Printed Circuit Board ◽  
Circuit Board ◽  
Printed Circuit

scholarly journals Inhaled Pulmonary Drug Delivery Platform Using Surface Acoustic Wave Atomization

2009 ◽  
Author(s):  
Aisha Qi ◽  
James R. Friend ◽  
Leslie Y. Yeo
Keyword(s):  
Drug Delivery ◽  
Lithium Niobate ◽  
Acoustic Wave ◽  
Size Distribution ◽  
Surface Acoustic Wave ◽  
Systemic Exposure ◽  
Pulmonary Drug Delivery ◽  
Lung Model ◽  
Working Fluid ◽  
Lung Area

Atomization has been widely applied in pulmonary drug delivery as a promising technology to transport drug formulations directly to the respiratory tract in the form of inhaled particles or droplets. Because of the targeted treatment, the drug can be delivered directly to the site of inflammation, thus the need for systemic exposure and the possibility of side effects are both reduced. Therefore pulmonary drug delivery has significant advantages over other methods in the treatment of respiratory diseases such as asthma. The most common atomization methods employed in pulmonary drug delivery are jet atomization and ultrasonic atomization. However, the difficulty is in producing monodispersed particles/droplets in a size range of 1–5 micron meter in diameter, necessary for deposition in the targeted lung area or lower respiratory airways, within a controllable fashion. In this paper, we demonstrate surface acoustic wave (SAW) atomization as an efficient technique to generate monodispersed aerosol to produce the required size distribution. The SAW atomizer is made of a 127.86 Y-X rotated single-crystal lithium niobate piezoelectric substrate, which is patterned with chromium-aluminum interdigital transducer (IDT) electrodes via UV lithography. When an alternating electric field is applied onto lithium niobate substrate through the IDT, a SAW, propagating across substrate surface with ten nanometer order amplitudes, is generated. When the SAW meets the liquid which is placed upon substrate, the acoustic energy carried by the wave induces atomization of the working fluid, which contains salbutamol as a model drug. In order to measure the size distribution of the atomized droplets, two methods are used. One is the laser diffraction based Spraytec technique and the other is an in-vitro lung modelthe one stage glass twin impinger. The former revealed that the mean diameter of the aerosol atomized was around 3 um which were confirmed by the lung model that demonstrated that nearly 80% of atomized drug aerosol was deposited in the simulated lung area. Moreover, the SAW atomizer only requires 1–3 W driving power, suggesting that it can be miniaturized for portable consumer use.

scholarly journals Design and Optimization of a Novel SAW Gyroscope Structure Based on Amplitude Modulation with 1-D Phononic Crystals

Micromachines ◽  
2021 ◽  
Vol 12 (12) ◽  
pp. 1485
Author(s):  
Fei Ge ◽  
Liye Zhao ◽  
Yang Zhang
Keyword(s):  
Signal Processing ◽  
Acoustic Wave ◽  
Surface Acoustic Wave ◽  
Amplitude Modulation ◽  
Phononic Crystal ◽  
Defect Mode ◽  
High Sensitivity ◽  
Phononic Crystals ◽  
Linear Range ◽  
One Dimensional

Surface acoustic wave gyroscopes (SAWGs), as a kind of all-solid-state micro-electro-mechanical system (MEMS) gyroscopes, can work normally under extremely high-impact environmental conditions. Among the current SAWGs, amplitude-modulated gyroscopes (AMGs) are all based on the same gyro effect, which was proved weak, and their sensitivity and intensity of the output are both lower than frequency-modulated gyroscopes (FMGs). However, because FMGs need to process a series of frequency signals, their signal processing and circuits are far less straightforward and simple than AMGs. In order to own both high-sensitivity and simple signal processing, a novel surface acoustic traveling wave gyroscope based on amplitude modulation is proposed, using one-dimensional phononic crystals (PCs) in this paper. In view of its specific structure, the proposed gyroscope consists of a surface acoustic wave oscillator and a surface acoustic wave delay line within a one-dimensional phononic crystal with a high-Q defect mode. In this paper, the working principle is analyzed theoretically through the partial wave method (PWM), and the gyroscopes with different numbers of PCs are also designed and studied by using the finite element method (FEM) and multiphysics simulation. The research results demonstrate that under a 1 V oscillator voltage output, the higher sensitivity of −23.1 mV·(rad/s)−1 in the linear range from −8 rad/s to 8 rad/s is reached when the gyro with three PC walls, and the wider linear range from −15 rad/s to 17.5 rad/s with the sensitivity of −6.7 mV·(rad/s)−1 with only one PC wall. Compared with the existing AMGs using metal dots to enhance the gyro effect, the sensitivity of the proposed gyro is increased by 15 to 112 times, and the linear range is increased by 4.6 to 186 times, even without the enhancement of the metal dots.

Paper Based Microfluidic Device Using Surface Acoustic Wave as Driving Source

2011 ◽  
Vol 130-134 ◽  
pp. 1658-1662
Author(s):  
An Liang Zhang ◽  
Qing Jiang Han
Keyword(s):  
Acoustic Wave ◽  
Surface Acoustic Wave ◽  
Chemical Reaction ◽  
Microfluidic Device ◽  
Filter Paper ◽  
Microfluidic System ◽  
Analyte Concentration ◽  
Interdigital Transducer ◽  
Driving Source ◽  
Piezoelectric Substrate

It is necessary to implement pretreatment operations for a paper based microfluidic device. A paper based microfluidic device with SAW driving microfluid has been implemented. Trance analyte to be detected was absorbed into a filter paper at first, and mounted on PDMS blocks on a piezoelectric substrate to ensure that the indicting filter paper has a little gap with the piezoelectric substrate. Reagents were then pipetted on the piezoelectric substrate and transported by surface acoustic wave excited by an interdigital transducer, which was fabricated on a 1280-yx LiNbO3 using micro-electrical technology. A color was developed due to chemical reaction, and the analyte concentration was evaluated by its grey value. Nitrate ion was detected using the microfluidic system.

A paper-based microfluidic device with cotton thread channels based on surface acoustic wave

2018 ◽  
Vol 526 (1) ◽  
pp. 24-32 ◽  
Author(s):  
An-Liang Zhang ◽  
Ya-Wei Cai ◽  
Yue Xu ◽  
Wei-Yue Liu
Keyword(s):  
Acoustic Wave ◽  
Surface Acoustic Wave ◽  
Microfluidic Device ◽  
Cotton Thread

Microfluidic device based on surface acoustic wave

2006 ◽  
Vol 118 (1-2) ◽  
pp. 380-385 ◽  
Author(s):  
D. Beyssen ◽  
L. Le Brizoual ◽  
O. Elmazria ◽  
P. Alnot
Keyword(s):  
Acoustic Wave ◽  
Surface Acoustic Wave ◽  
Microfluidic Device

scholarly journals Standing surface acoustic wave (SSAW)-based cell washing

Lab on a Chip ◽  
2015 ◽  
Vol 15 (1) ◽  
pp. 331-338 ◽  
Author(s):  
Sixing Li ◽  
Xiaoyun Ding ◽  
Zhangming Mao ◽  
Yuchao Chen ◽  
Nitesh Nama ◽  
...  
Keyword(s):  
Acoustic Wave ◽  
Surface Acoustic Wave ◽  
Microfluidic Device ◽  
Continuous Flow

We report a standing surface acoustic wave (SSAW)-based microfluidic device for cell and bead washing in a continuous flow.

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