scholarly journals Microtiter plate-sized standalone chip holder for microenvironmental physiological control in gas-impermeable microfluidic devices

Lab on a Chip ◽  
2014 ◽  
Vol 14 (11) ◽  
pp. 1816-1820 ◽  
Author(s):  
Björn Harink ◽  
Séverine Le Gac ◽  
David Barata ◽  
Clemens van Blitterswijk ◽  
Pamela Habibovic
Keyword(s):  
Cell Culture ◽  
Microfluidic Devices ◽  
Microtiter Plate ◽  
Physiological Control ◽  
Culture Systems ◽  
Physiological Conditions ◽  
Cell Culture Systems ◽  
Microfluidic Cell Culture

Microtiter plate-sized standalone chip holder for control of physiological conditions inside closed microfluidic cell culture systems, made from gas-impermeable materials.

Microfluidic cell culture systems for drug research

Lab on a Chip ◽  
2010 ◽  
Vol 10 (8) ◽  
pp. 939 ◽  
Author(s):  
Min-Hsien Wu ◽  
Song-Bin Huang ◽  
Gwo-Bin Lee
Keyword(s):  
Cell Culture ◽  
Drug Research ◽  
Culture Systems ◽  
Cell Culture Systems ◽  
Microfluidic Cell Culture

scholarly journals Quantitative inference of cellular parameters from microfluidic cell culture systems

2009 ◽  
Vol 103 (5) ◽  
pp. 966-974 ◽  
Author(s):  
Khamir Mehta ◽  
Geeta Mehta ◽  
Shuichi Takayama ◽  
Jennifer Linderman
Keyword(s):  
Cell Culture ◽  
Culture Systems ◽  
Cell Culture Systems ◽  
Microfluidic Cell Culture

scholarly journals Three-Dimensional Modeling of Avascular Tumor Growth in Both Static and Dynamic Culture Platforms

Micromachines ◽  
2019 ◽  
Vol 10 (9) ◽  
pp. 580 ◽  
Author(s):  
Ali Taghibakhshi ◽  
Maryam Barisam ◽  
Mohammad Said Saidi ◽  
Navid Kashaninejad ◽  
Nam-Trung Nguyen
Keyword(s):  
Cell Culture ◽  
Tumor Growth ◽  
Growth Kinetics ◽  
Three Dimensional ◽  
Culture Systems ◽  
Tumor Growth Kinetics ◽  
Cell Culture Systems ◽  
Proposed Model ◽  
Microfluidic Cell Culture ◽  
Avascular Tumor

Microfluidic cell culture platforms are ideal candidates for modeling the native tumor microenvironment because they can precisely reconstruct in vivo cellular behavior. Moreover, mathematical modeling of tumor growth can pave the way toward description and prediction of growth pattern as well as improving cancer treatment. In this study, a modified mathematical model based on concentration distribution is applied to tumor growth in both conventional static culture and dynamic microfluidic cell culture systems. Apoptosis and necrosis mechanisms are considered as the main inhibitory factors in the model, while tumor growth rate and nutrient consumption rate are modified in both quiescent and proliferative zones. We show that such modification can better predict the experimental results of tumor growth reported in the literature. Using numerical simulations, the effects of the concentrations of the nutrients as well as the initial tumor radius on the tumor growth are investigated and discussed. Furthermore, tumor growth is simulated by taking into account the dynamic perfusion into the proposed model. Subsequently, tumor growth kinetics in a three-dimensional (3D) microfluidic device containing a U-shaped barrier is numerically studied. For this case, the effect of the flow rate of culture medium on tumor growth is investigated as well. Finally, to evaluate the impact of the trap geometry on the tumor growth, a comparison is made between the tumor growth kinetics in two frequently used traps in microfluidic cell culture systems, i.e., the U-shaped barrier and microwell structures. The proposed model can provide insight into better predicting the growth and development of avascular tumor in both static and dynamic cell culture platforms.

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