Laser-ablation sampling for inductively coupled plasma distance-of-flight mass spectrometry

2015 ◽  
Vol 30 (1) ◽  
pp. 139-147 ◽  
Author(s):  
Alexander Gundlach-Graham ◽  
Elise A. Dennis ◽  
Steven J. Ray ◽  
Christie G. Enke ◽  
Charles J. Barinaga ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Laser Ablation ◽  
Inductively Coupled Plasma ◽  
Sample Introduction ◽  
Inductively Coupled ◽  
Flight Mass Spectrometry

Laser-ablation (LA) sample introduction is combined with a new simultaneous multi-element determining, velocity-based ICPMS approach called distance-of-flight mass spectrometry (DOFMS).

Capabilities of laser ablation inductively coupled plasma time-of-flight mass spectrometry

2017 ◽  
Vol 32 (10) ◽  
pp. 1946-1959 ◽  
Author(s):  
Marcel Burger ◽  
Gunnar Schwarz ◽  
Alexander Gundlach-Graham ◽  
Debora Käser ◽  
Bodo Hattendorf ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Laser Ablation ◽  
Inductively Coupled Plasma ◽  
Time Of Flight ◽  
Sample Introduction ◽  
Inductively Coupled ◽  
Flight Mass Spectrometry

Evaluation of capabilities offered by ICP-TOFMS for various laser-ablation-based sample introduction schemes.

Imaging of Ag NP transport through collagen-rich microstructures in fibroblast multicellular spheroids by high-resolution laser ablation inductively coupled plasma time-of-flight mass spectrometry

The Analyst ◽  
2019 ◽  
Vol 144 (16) ◽  
pp. 4935-4942 ◽  
Author(s):  
Akihiro Arakawa ◽  
Norbert Jakubowski ◽  
Gunda Koellensperger ◽  
Sarah Theiner ◽  
Andreas Schweikert ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Laser Ablation ◽  
High Resolution ◽  
Inductively Coupled Plasma ◽  
Time Of Flight ◽  
Multicellular Spheroids ◽  
Ag Nps ◽  
Inductively Coupled ◽  
Flight Mass Spectrometry

Intercellular Cu increased along with the number of accumulated Ag NPs.

Fractionation Effects in Laser Ablation Inductively Coupled Plasma Mass Spectrometry

1995 ◽  
Vol 49 (11) ◽  
pp. 1652-1660 ◽  
Author(s):  
Evan F. Cromwell ◽  
Peter Arrowsmith
Keyword(s):  
Mass Spectrometry ◽  
Laser Ablation ◽  
Inductively Coupled Plasma ◽  
Laser Pulses ◽  
Sample Surface ◽  
Sample Introduction ◽  
Matrix Analysis ◽  
Near Surface ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry

Aspects of laser ablation sample introduction for inductively coupled plasma mass spectrometry (ICPMS) have been investigated. For some analytes, nonrepresentative subsampling or fractionation is the major cause of poor analytical accuracy. Fractionation is prevalent for ablation at low laser fluence and with multiple laser pulses incident on the same area of the sample surface. The fluence dependence is explained by the relative depths of the melt- and heat-affected zones. Volatile analyte elements that are segregated in the bulk, or become segregated as the ablation zone is heated, are most prone to fractionation. For metal alloys, the extent of fractionation can be qualitatively predicted from the binary-phase diagram of the corresponding analyte matrix. Analysis by Auger electron spectroscopy showed that miscible elements may also be segregated at the near surface, with the extent of segregation growing with multiple laser pulses. Such segregation results in increased fractionation.

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