Modeling and analysis of innate immune responses induced by the host cells against hepatitis C virus infection

2015 ◽  
Vol 7 (5) ◽  
pp. 544-559 ◽  
Author(s):  
Ayesha Obaid ◽  
Jamil Ahmad ◽  
Anam Naz ◽  
Faryal Mehwish Awan ◽  
Rehan Zafar Paracha ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Immune Responses ◽  
Innate Immune ◽  
Host Cells ◽  
Innate Immune Responses ◽  
Hepatitis C Virus Infection ◽  
Modeling And Analysis

scholarly journals Hepatitis C Virus Induces Toll-Like Receptor 4 Expression, Leading to Enhanced Production of Beta Interferon and Interleukin-6

2006 ◽  
Vol 80 (2) ◽  
pp. 866-874 ◽  
Author(s):  
Keigo Machida ◽  
Kevin T. H. Cheng ◽  
Vicky M.-H. Sung ◽  
Alexandra M. Levine ◽  
Steven Foung ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
B Cells ◽  
Immune Responses ◽  
Interleukin 6 ◽  
Innate Immune ◽  
Hcv Infection ◽  
Innate Immune Responses ◽  
Altered Expression ◽  
Beta Interferon

ABSTRACT Hepatitis C virus (HCV) induces inflammatory signals, leading to hepatitis, hepatocellular carcinomas, and lymphomas. The mechanism of HCV involvement in the host's innate immune responses has not been well characterized. In this study, we analyzed expression and regulation of the entire panel of toll-like receptors (TLRs) in human B cells following HCV infection in vitro. Among all of the TLRs (TLRs 1 to 10) examined, only TLR4 showed an altered expression (a three- to sevenfold up-regulation) after HCV infection. Peripheral blood mononuclear cells from HCV-infected individuals also showed a higher expression level of TLR4 compared with those of healthy individuals. HCV infection significantly increased beta interferon (IFN-β) and interleukin-6 (IL-6) secretion from B cells, particularly after lipopolysaccharide stimulation. The increased IFN-β and IL-6 production was mediated by TLR4 induction, since the introduction of the small interfering RNA against TLR4 specifically inhibited the HCV-induced cytokine production. Among all of the viral proteins, only NS5A caused TLR4 induction in hepatocytes and B cells. NS5A specifically activated the promoter of the TLR4 gene in both hepatocytes and B cells. In conclusion, HCV infection directly induces TLR4 expression and thereby activates B cells, which may contribute to the host's innate immune responses.

scholarly journals Correction for Yi et al., “Hepatitis C Virus NS4B Can Suppress STING Accumulation To Evade Innate Immune Responses”

2018 ◽  
Vol 92 (2) ◽  
Author(s):  
Guanghui Yi ◽  
Yahong Wen ◽  
Chang Shu ◽  
Qingxia Han ◽  
Kouacou V. Konan ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Immune Responses ◽  
Innate Immune ◽  
Innate Immune Responses

Upregulated innate immune responses in a hepatitis C virus exposed uninfected cohort

2018 ◽  
Vol 68 ◽  
pp. S798
Author(s):  
I. Shawa ◽  
K. Bennett ◽  
D. Sheridan ◽  
D. Felmlee ◽  
D. Hegazy ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Immune Responses ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Exposed Uninfected
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