Sulfonamide formation from sodium sulfinates and amines or ammonia under metal-free conditions at ambient temperature

2015 ◽  
Vol 17 (3) ◽  
pp. 1395-1399 ◽  
Author(s):  
Kai Yang ◽  
Miaolin Ke ◽  
Yuanguang Lin ◽  
Qiuling Song
Keyword(s):  
Ambient Temperature ◽  
Efficient Method ◽  
Room Temperature ◽  
Metal Base ◽  
Metal Free ◽  
Highly Efficient ◽  
Reaction Proceeds

A practical and highly efficient method for the construction of a variety of sulfonamides mediated by I2 was demonstrated. The reaction proceeds readily at room temperature using a variety of sodium sulfinates and amines or ammonia in water in a metal-, base-, ligand-, or additive-free protocol. Primary, secondary and tertiary sulfonamides were obtained in good to excellent yields with a broad range of substrate tolerability.

Diiiodine/Potassium Persulfate Mediated Synthesis of 1,2,3-Thiadiazoles from N-Tosylhydrazones and a Thiocyanate Salt as a Sulfur Source under Transition-Metal-Free Conditions

Synlett ◽  
2021 ◽  
Author(s):  
Yadong Sun ◽  
Ablimit Abdukader ◽  
Yuhan Lu ◽  
Chenjiang Liu
Keyword(s):  
Transition Metal ◽  
Efficient Method ◽  
Room Temperature ◽  
Functional Group ◽  
Ammonium Thiocyanate ◽  
Potassium Persulfate ◽  
Sulfur Source ◽  
Coupling Reactions ◽  
Wide Scope ◽  
Metal Free

AbstractA highly efficient method for the synthesis of 1,2,3-thiadiazoles has been developed by utilizing readily available tosylhydrazones and ammonium thiocyanate with ecofriendly EtOH as the solvent at room temperature. The reaction shows a wide scope of substrates and good functional-group tolerance. This protocol can be scaled up to a gram level and can be applied to coupling reactions with 4-(4-bromophenyl)-1,2,3-thiadiazole as the substrate.

Phthalide synthesis through dehydrogenated lactonization of the C(sp3)–H bond by photoredox catalysis

2021 ◽  
Author(s):  
Hui Liu ◽  
Chao Liu ◽  
Shanyi Chen ◽  
Qihong Lai ◽  
Yulin Lin ◽  
...  
Keyword(s):  
Visible Light ◽  
Efficient Method ◽  
Room Temperature ◽  
Photoredox Catalysis ◽  
Metal Free

An efficient method for the direct oxidative lactonization of the C(sp3)–H bonds of benzyl via visible-light-induced photoredox catalysis. The metal-free protocol delivers diverse phthalides using O2 as the sole terminal oxidant at room temperature.

Room Temperature, Metal-Free, Regio-Selective Arylselenation of Anilines Using Diselenides as Selenium Source

Synthesis ◽  
2022 ◽  
Author(s):  
Rekha Bai ◽  
Kamlesh Kumar Dabaria ◽  
Satpal Singh Badsara
Keyword(s):  
Ambient Temperature ◽  
Room Temperature ◽  
Bond Formation ◽  
Metal Free ◽  
Aniline Derivatives

A metal-free direct C-H selenation of aniline derivatives via an iodine catalysed C-Se bond formation using diselenides as a selenium source at ambient temperature is described. A variety of aniline derivatives underwent regio-selective C-H selenation with different diselenides to afford the corresponding aryl selenoethers in good to excellent yields.

scholarly journals Highly Efficient Synthesis of Hindered 3-Azoindoles via Metal-Free C–H Functionalization of Indoles

Synthesis ◽  
2020 ◽  
Vol 52 (04) ◽  
pp. 574-580
Author(s):  
Nicolas Jacob ◽  
Lucas Guillemard ◽  
Joanna Wencel-Delord
Keyword(s):  
Steric Hindrance ◽  
Room Temperature ◽  
Efficient Synthesis ◽  
Atom Economy ◽  
Photochromic Compounds ◽  
Metal Free ◽  
Highly Efficient ◽  
Simple Protocol ◽  
Potential Applications

Although 3-azoindoles have recently emerged as an appealing family of photoswitch molecules, the synthesis of such compounds has been poorly covered in the literature. Herein a high-yielding and operationally simple protocol is reported allowing the synthesis of 3-azoindoles, featuring important steric hindrance around the azo motif. Remarkably, this C–H coupling is characterized by excellent atom economy and occurs under metal-free conditions, at room temperature, and within few minutes, delivering the expected products in excellent yields (quantitatively in most of the cases). Accordingly, a library of new molecules, with potential applications as photochromic compounds, is prepared.

Copper(II)-Promoted Oxidation/[3+2]Cycloaddition/Aromatization Cascade: Efficient Synthesis of Tetrasubstituted NH-Pyrrole from Chalcones and Iminodiacetates

Synlett ◽  
2019 ◽  
Vol 30 (12) ◽  
pp. 1442-1446 ◽  
Author(s):  
Zhang-qi Lin ◽  
Chao-dong Li ◽  
Zi-chun Zhou ◽  
Shuai Xue ◽  
Jian-rong Gao ◽  
...  
Keyword(s):  
Efficient Method ◽  
Cascade Reaction ◽  
Oxidative Cyclization ◽  
Efficient Synthesis ◽  
Reaction Conditions ◽  
Highly Efficient ◽  
Wide Range ◽  
Reaction Proceeds

A simple and highly efficient method for the preparation of tetrasubstituted NH-pyrrole from a wide range of chalcones and diethyl iminodiacetates via a Cu(OAc)2-promoted oxidation/[3+2]cycloaddition/aromatization cascade reaction has been developed. This reaction proceeds through dehydrogenations, deamination, and oxidative cyclization, affording the corresponding products in good to excellent yields. This convenient methodology for constructing tetrasubstituted NH-pyrroles has several advantages over existing methods, such as the use of easily accessible chalcones and readily available diethyl iminodiacetates, and mild reaction conditions. A wide range of substrates are tolerated.

scholarly journals Highly Efficient Selective Oxygenation of Sulfides to Sulfoxides by Oxalic Acid Dihydrate in the Presence of H2O2

2012 ◽  
Vol 9 (2) ◽  
pp. 863-868 ◽  
Author(s):  
Masoud Mokhtary ◽  
Mohammad Qandalee ◽  
Masoumeh Rastegar Niaki
Keyword(s):  
Hydrogen Peroxide ◽  
Oxalic Acid ◽  
Ambient Temperature ◽  
Efficient Method ◽  
Oxalic Acid Dihydrate ◽  
Oxidation Of Sulfides ◽  
Highly Efficient

A highly efficient method for the oxidation of sulfides to sulfoxides using oxalic acid dihydrate in the presence of hydrogen peroxide has been developed. A versatile procedure for the oxidation of sulfides to sulfoxides without any over-oxidation to sulfones has been reported. This procedure cleanly oxidizes sulfides to the corresponding sulfoxides in excellent yields at ambient temperature.

Metal-free regioselective C–H chalcogenylation of coumarins/(hetero)arenes at ambient temperature

2020 ◽  
Vol 56 (12) ◽  
pp. 1847-1850
Author(s):  
Zengqiang Song ◽  
Chaochao Ding ◽  
Shaoli Wang ◽  
Qian Dai ◽  
Yaoguang Sheng ◽  
...  
Keyword(s):  
Ambient Temperature ◽  
Room Temperature ◽  
Practical Method ◽  
Metal Free

A novel and practical method for the direct regioselective chalcogenylation of coumarins at the C3-postion and selenation of other (hetero)arenes has been achieved using PIFA as a promoter at room temperature.

Graphite oxide: a metal free highly efficient carbocatalyst for the synthesis of 1,5-benzodiazepines under room temperature and solvent free heating conditions

2017 ◽  
Vol 19 (6) ◽  
pp. 1576-1585 ◽  
Author(s):  
Ramen Jamatia ◽  
Ajay Gupta ◽  
Binoyargha Dam ◽  
Mithu Saha ◽  
Amarta Kumar Pal
Keyword(s):  
Graphite Oxide ◽  
Room Temperature ◽  
Solvent Free ◽  
Metal Free ◽  
Highly Efficient

We report a sustainable and metal free carbocatalyst, graphite oxide, for the synthesis of 1,5-benzodiazepines under room temperature and solvent free heating conditions.

scholarly journals Highly Efficient and Ambient-Temperature Synthesis of Benzimidazoles via Co(III)/Co(II)-Mediated Redox Catalysis

Catalysts ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 59
Author(s):  
Renyuan Zhong ◽  
Wulin Xiong ◽  
Haoyuan Zhang ◽  
Tongtong Zeng ◽  
Shanshan Gong ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Ambient Temperature ◽  
Efficient Method ◽  
Solvent Free ◽  
Redox Catalysis ◽  
Temperature Synthesis ◽  
Fast Green ◽  
Stoichiometric Amount ◽  
Highly Efficient ◽  
Solvent Free Conditions

An efficient method for ambient-temperature synthesis of a variety of 2-substituted and 1,2-disubstituted benzimidazoles from aldehyde and phenylenediamine substrates has been developed by utilizing Co(III)/Co(II)-mediated redox catalysis. The combination of only 1 mol% of Co(acac)2 and stoichiometric amount of hydrogen peroxide provides a fast, green, and mild access to a diversity of benzimidazoles under solvent-free conditions.

scholarly journals Highly Efficient Recyclable Sol Gel Polymer Catalyzed One Pot Difunctionalization of Alkynes

Molecules ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 1879
Author(s):  
Justin Domena ◽  
Carlos Chong ◽  
Qiaxian Johnson ◽  
Bhanu Chauhan ◽  
Yalan Xing
Keyword(s):  
Reaction Time ◽  
Room Temperature ◽  
Functional Group ◽  
Sol Gel ◽  
One Pot ◽  
Short Reaction Time ◽  
Metal Free ◽  
Highly Efficient

Amino-bridged gel polymer P1 was discovered to catalyze alkyne halo-functionalization in excellent yields, regioselectivity, functional group compatibility, and recyclability. We have observed that both aromatic and aliphatic alkynes can be converted to α,α-dihalogenated ketones in the presence of polymer P1 under metal-free conditions at room temperature within a short reaction time.

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