Pressurized hot water flow-through extraction system scale up from the laboratory to the pilot scale

2014 ◽  
Vol 16 (6) ◽  
pp. 3186-3194 ◽  
Author(s):  
P. O. Kilpeläinen ◽  
S. S. Hautala ◽  
O. O. Byman ◽  
L. J. Tanner ◽  
R. I. Korpinen ◽  
...  
Keyword(s):  
Water Flow ◽  
Scale Up ◽  
Scaling Up ◽  
Pilot Scale ◽  
Hot Water ◽  
Extraction System ◽  
Flow Through

The scaling up of the pressurized hot water flow-through extraction system for sawdust by a factor of 6000.

Ice removal from wind turbine using hot water flow through blade

2017 ◽  
Author(s):  
Datta. S. Chavan ◽  
Rajendra Pal ◽  
Jaywant Sankpal ◽  
Siddhharth ◽  
Vivek Sahil ◽  
...  
Keyword(s):  
Wind Turbine ◽  
Water Flow ◽  
Hot Water ◽  
Flow Through

A Scaling-up Approach from Experimental Tunnel to Spray Dryer

2010 ◽  
Vol 6 (1) ◽  
Author(s):  
Xuan-You Li ◽  
Ireneusz Zbicinski ◽  
Jing Wu
Keyword(s):  
Spray Drying ◽  
Scale Up ◽  
Scaling Up ◽  
Pilot Scale ◽  
Drying Kinetics ◽  
Water Evaporation ◽  
Small Scale ◽  
Spray Dryer ◽  
Cfd Modelling ◽  
Initial Water

A scaling-up approach from drying of a thin layer wet material in a experimental tunnel to a pilot scale spray drying was developed through determining drying kinetics of quick evaporation process. Maltodextin was selected as solid material in solution to be dried. Critical moisture contents as a function of initial water evaporation rate (drying rate) shows that there is the same variation between the small scale test tunnel and the pilot scale spray dryer. Result of CFD modelling demonstrates that drying kinetics obtained from the small-scale tunnel could be properly applied to scale-up the spray drying process.

Scale-up and biomass hold-up characteristics of biological fluidized bed reactors

1994 ◽  
Vol 29 (10-11) ◽  
pp. 353-360 ◽  
Author(s):  
I. Ozturk ◽  
M. Turan ◽  
A. H. Idris
Keyword(s):  
Fluidized Bed ◽  
Scale Up ◽  
Experimental Studies ◽  
Scaling Up ◽  
Pilot Scale ◽  
Fluidized Bed Reactors ◽  
Biofilm Thickness ◽  
Study Results ◽  
Scaling Down ◽  
Comprehensive Study

This paper presents a comprehensive study results on scale-up and biomass hold-up characteristics of biological fluidized bed reactors (BFBR). The overall objective of this study was to establish and test some basic design criteria for the scaling-up or scaling-down of anaerobic fluidized bed reactors. A 12.5 1 laboratory-scale fluidized bed was designed and constructed based on a geometrically similar 70 1 pilot scale fluidized bed and the process performances were compared. Biomass hold up characteristics of the BFBRs were also investigated during the experimental studies. A general expression was developed for predicting the biological fludized bed porosities. Using this expression, both the local and overall fluidized bed porosities could be predicted depending on biofilm thickness, expansion coefficient, media diameter and density. The validity of this expression was tested with the data from this study.

scholarly journals ESCALONAMENTO DE TECNOLOGIAS: DESENVOLVIMENTO DE PRODUTO E PROCESSO DO LABORATÓRIO À ESCALA PILOTO CONECTADO AO MERCADO (PARTE 1)

Química Nova ◽  
2020 ◽  
Author(s):  
Elimar Vasconcellos ◽  
Priscila Souza ◽  
Marcella Franco ◽  
Vinícius Castro ◽  
Lorena Souza ◽  
...  
Keyword(s):  
Pilot Plant ◽  
Process Development ◽  
Scale Up ◽  
Feasibility Studies ◽  
Basic Research ◽  
Scaling Up ◽  
Pilot Scale ◽  
Economic Feasibility ◽  
One Step ◽  
Expensive Process

TECHNOLOGY SCALE UP: PROCESS DEVELOPMENT FROM THE LABORATORY TO PILOT SCALE CONNECTED TO MARKET (PART 1). In this article, it is described the main aspects to be considered during the process of scaling up hard sciences technologies developed in the Science and Technology Institutes aiming at industrial application. Based on the experience of our group in scaling up, pre-acceleration, and acceleration of different technologies, a methodology was developed and divided into four main stages: Step 1, which involves basic research, Step 2 with a focus on product development, and Step 3 with a focus on process development, all on the laboratory scale and the last one, Step 4 focused on pilot plant development. The most important aspect of this article is to show that many critical questions can be answered even in the laboratory phase. In this way, the risks of Step 4 are minimized. Step 4 is a complicated, lengthy, and expensive process of construction and operation of a pilot plant. Aspects such as proof of concept, technical and economic feasibility studies, minimum viable product, capital expenditures, and operating expenses of pilot plants are approached in a simplified way to serve as a basis for researchers who wants to know the long path to be followed by technology before reaching the industry, consequently the market.

scholarly journals Theoretical and Practical Issues That Are Relevant When Scaling Up hMSC Microcarrier Production Processes

2016 ◽  
Vol 2016 ◽  
pp. 1-15 ◽  
Author(s):  
Valentin Jossen ◽  
Cedric Schirmer ◽  
Dolman Mostafa Sindi ◽  
Regine Eibl ◽  
Matthias Kraume ◽  
...  
Keyword(s):  
Stem Cells ◽  
Scale Up ◽  
Human Mesenchymal Stem Cells ◽  
Scaling Up ◽  
Pilot Scale ◽  
Culture Broth ◽  
Cell Therapies ◽  
Computational Fluid Dynamics Cfd ◽  
Cell Densities ◽  
Stirred Bioreactors

The potential of human mesenchymal stem cells (hMSCs) for allogeneic cell therapies has created a large amount of interest. However, this presupposes the availability of efficient scale-up procedures. Promising results have been reported for stirred bioreactors that operate with microcarriers. Recent publications focusing on microcarrier-based stirred bioreactors have demonstrated the successful use of Computational Fluid Dynamics (CFD) and suspension criteria (NS1u,NS1) for rapidly scaling up hMSC expansions from mL- to pilot scale. Nevertheless, one obstacle may be the formation of large microcarrier-cell-aggregates, which may result in mass transfer limitations and inhomogeneous distributions of stem cells in the culture broth. The dependence of microcarrier-cell-aggregate formation on impeller speed and shear stress levels was investigated for human adipose derived stromal/stem cells (hASCs) at the spinner scale by recording the Sauter mean diameter (d32) versus time. Cultivation at the suspension criteria providedd32values between 0.2 and 0.7 mm, the highest cell densities (1.25 × 106cells mL−1hASCs), and the highest expansion factors (117.0 ± 4.7 on day 7), while maintaining the expression of specific surface markers. Furthermore, suitability of the suspension criterionNS1uwas investigated for scaling up microcarrier-based processes in wave-mixed bioreactors for the first time.

Scaling up Process Output of Monomer Reactor

2013 ◽  
Vol 748 ◽  
pp. 299-303 ◽  
Author(s):  
Anika Zafiah M. Rus ◽  
Muhamad Soqhimi Mohamad Isa ◽  
Nurul Saidatul Syida Sulong
Keyword(s):  
Scale Up ◽  
Scaling Up ◽  
Pilot Scale ◽  
Industrial Scale ◽  
Important Process ◽  
Laboratory Equipment ◽  
Cooking Oil ◽  
Used Cooking Oil ◽  
Process Output

A monomer processing reactor is a device to process used cooking oil into new substance that can be used for other applications. In this study, used cooking oil was converted to monomer via simple reactor comprised of stirrer started with laboratory scale of 2L to 5L of monomer production. A scale up process is an important process for approaching industrial scale productions. The scale up process was increased to pilot scale before it reaches to industrial scale. The reactor is designed based on lab scale process for producing monomer from used cooking oil. The most important point of the device design is to produce larger amount of monomer compared to lab scale equipment. The device can produce 15liters of monomer per production. The monomer has the same properties and quality of monomer that were produced using laboratory equipment.

scholarly journals Pressurized Hot Water Flow-through Extraction of Birch Sawdust with Acetate pH Buffer

BioResources ◽  
2013 ◽  
Vol 8 (4) ◽  
Author(s):  
Petri Kilpeläinen ◽  
Veikko Kitunen ◽  
Andrey Pranovich ◽  
Hannu Ilvesniemi ◽  
Stefan Willför
Keyword(s):  
Water Flow ◽  
Hot Water ◽  
Flow Through ◽  
Ph Buffer

scholarly journals Pressurized hot water flow-through extraction of birch sawdust – Effects of sawdust density and sawdust size

2014 ◽  
Vol 29 (4) ◽  
pp. 547-556 ◽  
Author(s):  
Petri Kilpeläinen ◽  
Veikko Kitunen ◽  
Hannu Ilvesniemi ◽  
Jarl Hemming ◽  
Andrey Pranovich ◽  
...  
Keyword(s):  
Water Flow ◽  
Hot Water ◽  
Flow Through
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