Insight into inhibition of the human amyloid beta protein precursor (APP: PDB ID 3UMI) using (E)-N-(pyridin-2-ylmethylene)arylamine (LR) models: structure elucidation of a family of ZnX2-LRcomplexes

2015 ◽  
Vol 44 (5) ◽  
pp. 2359-2369 ◽  
Author(s):  
Tushar S. Basu Baul ◽  
Sajal Kundu ◽  
Palwinder Singh ◽  
Shaveta Shaveta ◽  
M. Fátima C. Guedes da Silva
Keyword(s):  
Amyloid Beta ◽  
Structure Elucidation ◽  
Amyloid Beta Protein ◽  
X Ray Diffraction ◽  
Protein Precursor ◽  
X Ray ◽  
Amyloid Beta Protein Precursor ◽  
Insight Into

LRshows interactions with the human amyloid beta protein precursor (APP)viazinc atoms. Such interactions were confirmed from the X-ray diffraction studies.

X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid .beta.-protein precursor

Biochemistry ◽  
1990 ◽  
Vol 29 (43) ◽  
pp. 10018-10022 ◽  
Author(s):  
Thomas R. Hynes ◽  
Michael Randal ◽  
Laura A. Kennedy ◽  
Charles Eigenbrot ◽  
Anthony A. Kossiakoff
Keyword(s):  
Crystal Structure ◽  
Protease Inhibitor ◽  
Amyloid Beta ◽  
Amyloid Beta Protein ◽  
Protein Precursor ◽  
X Ray ◽  
Amyloid Beta Protein Precursor

Proteolytic processing of the amyloid-beta protein precursor of Alzheimer's disease

2002 ◽  
Vol 38 ◽  
pp. 37-49 ◽  
Author(s):  
Janelle Nunan ◽  
David H Small
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Alternative Pathway ◽  
Protein A ◽  
Proteolytic Processing ◽  
Gamma Secretase ◽  
Amyloid Beta Protein ◽  
Protein Precursor ◽  
Amyloid Beta Protein Precursor

The proteolytic processing of the amyloid-beta protein precursor plays a key role in the development of Alzheimer's disease. Cleavage of the amyloid-beta protein precursor may occur via two pathways, both of which involve the action of proteases called secretases. One pathway, involving beta- and gamma-secretase, liberates amyloid-beta protein, a protein associated with the neurodegeneration seen in Alzheimer's disease. The alternative pathway, involving alpha-secretase, precludes amyloid-beta protein formation. In this review, we describe the progress that has been made in identifying the secretases and their potential as therapeutic targets in the treatment or prevention of Alzheimer's disease.

scholarly journals Thrombin receptor activation induces secretion and nonamyloidogenic processing of amyloid beta-protein precursor.

1994 ◽  
Vol 269 (36) ◽  
pp. 22623-22627 ◽  
Author(s):  
J. Davis-Salinas ◽  
S.M. Saporito-Irwin ◽  
F.M. Donovan ◽  
D.D. Cunningham ◽  
W.E. Van Nostrand
Keyword(s):  
Amyloid Beta ◽  
Receptor Activation ◽  
Thrombin Receptor ◽  
Amyloid Beta Protein ◽  
Protein Precursor ◽  
Amyloid Beta Protein Precursor

Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch)

Science ◽  
1990 ◽  
Vol 248 (4959) ◽  
pp. 1120-1122 ◽  
Author(s):  
C Van Broeckhoven ◽  
J Haan ◽  
E Bakker ◽  
J. Hardy ◽  
W Van Hul ◽  
...  
Keyword(s):  
Amyloid Beta ◽  
Cerebral Hemorrhage ◽  
Amyloid Beta Protein ◽  
Protein Precursor ◽  
Amyloid Beta Protein Precursor

Protease nexin-II (amyloid beta-protein precursor): a platelet alpha-granule protein

Science ◽  
1990 ◽  
Vol 248 (4956) ◽  
pp. 745-748 ◽  
Author(s):  
W. Van Nostrand ◽  
A. Schmaier ◽  
J. Farrow ◽  
D. Cunningham
Keyword(s):  
Amyloid Beta ◽  
Amyloid Beta Protein ◽  
Protein Precursor ◽  
Granule Protein ◽  
Amyloid Beta Protein Precursor ◽  
Protease Nexin
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