Aromatic C-nitrosation by a copper(ii)–nitrosyl complex

2015 ◽  
Vol 44 (4) ◽  
pp. 1829-1835 ◽  
Author(s):  
Kanhu Charan Rout ◽  
Biplab Mondal
Keyword(s):  
Nitric Oxide ◽  
Aromatic Ring ◽  
Methanol Solution ◽  
Sulphonic Acid ◽  
Nitrosyl Complex ◽  
P Addition

Addition of nitric oxide to the methanol solution of copper(ii) complex of 4-amino-3-hydroxy-1-sulphonic acid, resulted in the reduction of Cu(ii) center through unstable copper(ii)-nitrosyl intermediate. The reduction was accompanied with simultaneous C-nitrosation of the aromatic ring of the ligand.

A nitric oxide releaser based on the μ-oxo-hexaacetate-bis(4-methylpyridine)triruthenium nitrosyl complex

2005 ◽  
Vol 358 (10) ◽  
pp. 2891-2899 ◽  
Author(s):  
Henrique E. Toma ◽  
Anamaria D.P. Alexiou ◽  
André Luiz B. Formiga ◽  
Marcelo Nakamura ◽  
Sergio Dovidauskas ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitrosyl Complex

Ultrafast Photochemistry of a Molybdenum Carbonyl-Nitrosyl Complex with a Triazacyclononane Coligand

2021 ◽  
Author(s):  
Niklas Gessner ◽  
Anna Karina Bäck ◽  
Johannes Knorr ◽  
Christoph Nagel ◽  
Philipp Marquetand ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Carbon Monoxide ◽  
Transition Metal ◽  
Metal Complexes ◽  
Small Molecules ◽  
Transition Metal Complexes ◽  
Nitrosyl Complex ◽  
Molybdenum Carbonyl

Transition metal complexes capable of releasing small molecules such as carbon monoxide and nitric oxide upon photoactivation are versatile tools in various fields of chemistry and biology. In this work,...

scholarly journals Thiadiazoline- and Pyrazoline-Based Carboxamides and Carbothioamides: Synthesis and Inhibition against Nitric Oxide Synthase

2018 ◽  
Vol 2018 ◽  
pp. 1-15 ◽  
Author(s):  
Fabio Arias ◽  
M. Encarnación Camacho ◽  
M. Dora Carrión ◽  
Meriem Chayah ◽  
Miguel Romero ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Aromatic Ring ◽  
Main Chain ◽  
Heterocyclic System ◽  
The Novel ◽  
Structure Activity ◽  
Inhibitory Activities ◽  
Oxide Synthase ◽  
Inos Inhibition

Two new families of pyrazoline and thiadiazoline heterocycles have been developed. Their inhibitory activities against two different isoforms of nitric oxide synthase (inducible and neuronal NOS) are reported. The novel derivatives were synthesized combining the arylthiadiazoline or arylpyrazoline skeleton and a carboxamide or carbothioamide moiety, used as starting material ethyl 2-nitrobenzoates or substituted nitrobenzaldehydes, respectively. The structure-activity relationships of final molecules are discussed in terms of the R1 radical effects in the aromatic ring, the Y atom in the heterocyclic system, the X heteroatom in the main chain, and the R2 substituent in the carboxamide or carbothioamide rest. In general, thiadiazolines (5a–e) inhibit preferentially the neuronal isoform; among them, 5a is the best nNOS inhibitor (74.11% at 1 mM, IC50 = 420 μM). In contrast, pyrazolines (6a–r) behave better as iNOS than nNOS inhibitors, 6m being the best molecule of this series (76.86% at 1 mM of iNOS inhibition, IC50 = 130 μM) and the most potent of all tested compounds.

scholarly journals Neuronal Nitric Oxide Synthase Self-inactivates by Forming a Ferrous-Nitrosyl Complex during Aerobic Catalysis

1995 ◽  
Vol 270 (39) ◽  
pp. 22997-23006 ◽  
Author(s):  
Husam M. Abu-Soud ◽  
Jianling Wang ◽  
Denis L. Rousseau ◽  
Jon M. Fukuto ◽  
Louis J. Ignarro ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Neuronal Nitric Oxide Synthase ◽  
Nitrosyl Complex ◽  
Oxide Synthase

scholarly journals Role of inducible nitric oxide synthase in trinitrobenzene sulphonic acid induced colitis in mice

Gut ◽  
1999 ◽  
Vol 45 (6) ◽  
pp. 864-873 ◽  
Author(s):  
D-M McCafferty ◽  
M Miampamba ◽  
E Sihota ◽  
K A Sharkey ◽  
P Kubes
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Sulphonic Acid ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide ◽  
Trinitrobenzene Sulphonic Acid

Visible Light Induced Reversible Extrusion of Nitric Oxide from a Ruthenium(II) Nitrosyl Complex:  A Facile Delivery of Nitric Oxide

2005 ◽  
Vol 127 (40) ◽  
pp. 13758-13759 ◽  
Author(s):  
Raju Prakash ◽  
Alexander U. Czaja ◽  
Frank W. Heinemann ◽  
Dieter Sellmann
Keyword(s):  
Nitric Oxide ◽  
Visible Light ◽  
Nitrosyl Complex

Water-Soluble Two-Photon Absorbing Nitrosyl Complex for Light-Activated Therapy through Nitric Oxide Release

2008 ◽  
Vol 5 (3) ◽  
pp. 389-398 ◽  
Author(s):  
Qingdong Zheng ◽  
Adela Bonoiu ◽  
Tymish Y. Ohulchanskyy ◽  
Guang S. He ◽  
Paras N. Prasad
Keyword(s):  
Nitric Oxide ◽  
Water Soluble ◽  
Nitrosyl Complex ◽  
Nitric Oxide Release ◽  
Two Photon

H2S and HS− donor NaHS releases nitric oxide from nitrosothiols, metal nitrosyl complex, brain homogenate and murine L1210 leukaemia cells

2008 ◽  
Vol 457 (2) ◽  
pp. 271-279 ◽  
Author(s):  
Karol Ondrias ◽  
Andrej Stasko ◽  
Sona Cacanyiova ◽  
Zdena Sulova ◽  
Olga Krizanova ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Brain Homogenate ◽  
Nitrosyl Complex ◽  
Metal Nitrosyl
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