Hydrothermal synthesis of core–shell structured TbPO4:Ce3+@TbPO4:Gd3+nanocomposites for magnetic resonance and optical imaging

2014 ◽  
Vol 43 (32) ◽  
pp. 12321-12328 ◽  
Author(s):  
Xiao-yan Kuang ◽  
Huan Liu ◽  
Wen-yong Hu ◽  
Yuan-zhi Shao
Keyword(s):  
Hydrothermal Synthesis ◽  
Magnetic Resonance ◽  
Cancer Diagnosis ◽  
Early Cancer ◽  
Core Shell ◽  
Promising Alternative ◽  
Non Invasive ◽  
Early Cancer Diagnosis ◽  
Alternative Approach ◽  
Highly Sensitive

Multi-modal imaging based on multifunctional nanoparticles provides deep, non-invasive and highly sensitive imaging and is a promising alternative approach that can improve the sensitivity of early cancer diagnosis.

Highly sensitive fluorescence quantification of intracellular telomerase activity by repeat G-rich DNA enhanced silver nanoclusters

2018 ◽  
Vol 6 (28) ◽  
pp. 4583-4591 ◽  
Author(s):  
Shan Huang ◽  
Huiqin Yao ◽  
Wenjing Wang ◽  
Jian-Rong Zhang ◽  
Jun-Jie Zhu
Keyword(s):  
Cancer Diagnosis ◽  
Therapeutic Target ◽  
Early Cancer ◽  
Telomerase Activity ◽  
Silver Nanoclusters ◽  
Early Cancer Diagnosis ◽  
Highly Sensitive

As an important biomarker for early cancer diagnosis and a valuable therapeutic target, the detection and monitoring of telomerase activity has attracted extensive attention.

scholarly journals A New Look into Cancer—A Review on the Contribution of Vibrational Spectroscopy on Early Diagnosis and Surgery Guidance

Cancers ◽  
2021 ◽  
Vol 13 (21) ◽  
pp. 5336
Author(s):  
Adriana P. Mamede ◽  
Inês P. Santos ◽  
Ana L. M. Batista de Batista de Carvalho ◽  
Paulo Figueiredo ◽  
Maria C. Silva ◽  
...  
Keyword(s):  
Vibrational Spectroscopy ◽  
Cancer Diagnosis ◽  
Early Cancer ◽  
Diagnostic Technique ◽  
Histopathological Analysis ◽  
Morphological Alterations ◽  
Non Invasive ◽  
Early Cancer Diagnosis ◽  
Tremendous Progress ◽  
Intraoperative Margin Assessment

In 2020, approximately 10 million people died of cancer, rendering this disease the second leading cause of death worldwide. Detecting cancer in its early stages is paramount for patients’ prognosis and survival. Hence, the scientific and medical communities are engaged in improving both therapeutic strategies and diagnostic methodologies, beyond prevention. Optical vibrational spectroscopy has been shown to be an ideal diagnostic method for early cancer diagnosis and surgical margins assessment, as a complement to histopathological analysis. Being highly sensitive, non-invasive and capable of real-time molecular imaging, Raman and Fourier transform infrared (FTIR) spectroscopies give information on the biochemical profile of the tissue under analysis, detecting the metabolic differences between healthy and cancerous portions of the same sample. This constitutes tremendous progress in the field, since the cancer-prompted morphological alterations often occur after the biochemical imbalances in the oncogenic process. Therefore, the early cancer-associated metabolic changes are unnoticed by the histopathologist. Additionally, Raman and FTIR spectroscopies significantly reduce the subjectivity linked to cancer diagnosis. This review focuses on breast and head and neck cancers, their clinical needs and the progress made to date using vibrational spectroscopy as a diagnostic technique prior to surgical intervention and intraoperative margin assessment.

scholarly journals Gene Expression Correlation for Cancer Diagnosis: A Pilot Study

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Binbing Ling ◽  
Lifeng Chen ◽  
Qiang Liu ◽  
Jian Yang
Keyword(s):  
Pilot Study ◽  
Cancer Progression ◽  
Cancer Diagnosis ◽  
Early Cancer ◽  
Correlation Coefficients ◽  
Gene Expressions ◽  
Clinical Biomarkers ◽  
Biomolecular Networks ◽  
Early Cancer Diagnosis ◽  
Novel Strategy

Poor prognosis for late-stage, high-grade, and recurrent cancers has been motivating cancer researchers to search for more efficient biomarkers to identify the onset of cancer. Recent advances in constructing and dynamically analyzing biomolecular networks for different types of cancer have provided a promising novel strategy to detect tumorigenesis and metastasis. The observation of different biomolecular networks associated with normal and cancerous states led us to hypothesize that correlations for gene expressions could serve as valid indicators of early cancer development. In this pilot study, we tested our hypothesis by examining whether the mRNA expressions of three randomly selected cancer-related genesPIK3C3,PIM3, andPTENwere correlated during cancer progression and the correlation coefficients could be used for cancer diagnosis. Strong correlations(0.68≤r≤1.0)were observed betweenPIK3C3andPIM3in breast cancer, betweenPIK3C3andPTENin breast and ovary cancers, and betweenPIM3andPTENin breast, kidney, liver, and thyroid cancers during disease progression, implicating that the correlations for cancer network gene expressions could serve as a supplement to current clinical biomarkers, such as cancer antigens, for early cancer diagnosis.

Endoscopic Ultraviolet-Induced Autofluorescence Spectroscopy of the Esophagus: Tissue Characterization and Potential for Early Cancer Diagnosis

Endoscopy ◽  
2000 ◽  
Vol 32 (10) ◽  
pp. 756-765 ◽  
Author(s):  
G. Bourg-Heckly ◽  
J. Blais ◽  
J.-J. Padilla ◽  
O. Bourdon ◽  
J. Etienne ◽  
...  
Keyword(s):  
Cancer Diagnosis ◽  
Tissue Characterization ◽  
Early Cancer ◽  
Early Cancer Diagnosis ◽  
Autofluorescence Spectroscopy

scholarly journals Improving early cancer diagnosis in primary care

Prescriber ◽  
2020 ◽  
Vol 31 (9) ◽  
pp. 10-14
Author(s):  
Samuel W D Merriel ◽  
Willie Hamilton
Keyword(s):  
Primary Care ◽  
Cancer Diagnosis ◽  
Early Cancer ◽  
Early Cancer Diagnosis
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