scholarly journals Correction: The physical properties of supramolecular peptide assemblies: from building block association to technological applications

2014 ◽  
Vol 43 (20) ◽  
pp. 7236-7236 ◽  
Author(s):  
Lihi Adler-Abramovich ◽  
Ehud Gazit
Keyword(s):  
Physical Properties ◽  
Building Block ◽  
Block Association

scholarly journals Development of an Efficient Route to 2-Ethynylglycerol for the Synthesis of Islatravir

2021 ◽  
Author(s):  
Stephan M. Rummelt ◽  
Ji Qi ◽  
Yonggang Chen ◽  
James F. Dropinski ◽  
Gregory Hughes ◽  
...  
Keyword(s):  
Physical Properties ◽  
Building Block ◽  
Manufacturing Process ◽  
Process Development ◽  
Nucleoside Analog ◽  
Efficient Synthesis ◽  
Efficient Route ◽  
Acid Catalyzed ◽  
Initial Route ◽  
Nucleophile Addition

The unnatural, alkyne-containing nucleoside analog islatravir (MK-8591) is synthetically accessed through a biocatalytic cascade starting from 2-ethynylglycerol as a building block. Herein, we describe the development of an efficient synthesis of this building block including the initial route, route scouting and final process development. Key challenges that have been overcome are the development of an efficient and safe acetylenic nucleophile addition to an appropriate ketone, and the identification of a 2-ethynylpropane-1,2,3-triol derivative with favorable physical properties. An acid-catalyzed cracking of commercially available 1,3-dihydroxyacetone dimer and subsequent 1,2-addition of an acetylenic nucleophile has been discovered and optimized into the manufacturing process

scholarly journals Development of an Efficient Route to 2-Ethynylglycerol for the Synthesis of Islatravir

2021 ◽  
Author(s):  
Stephan M. Rummelt ◽  
Ji Qi ◽  
Yonggang Chen ◽  
James F. Dropinski ◽  
Gregory Hughes ◽  
...  
Keyword(s):  
Physical Properties ◽  
Building Block ◽  
Manufacturing Process ◽  
Process Development ◽  
Nucleoside Analog ◽  
Efficient Synthesis ◽  
Efficient Route ◽  
Acid Catalyzed ◽  
Initial Route ◽  
Nucleophile Addition

The unnatural, alkyne-containing nucleoside analog islatravir (MK-8591) is synthetically accessed through a biocatalytic cascade starting from 2-ethynylglycerol as a building block. Herein, we describe the development of an efficient synthesis of this building block including the initial route, route scouting and final process development. Key challenges that have been overcome are the development of an efficient and safe acetylenic nucleophile addition to an appropriate ketone, and the identification of a 2-ethynylpropane-1,2,3-triol derivative with favorable physical properties. An acid-catalyzed cracking of commercially available 1,3-dihydroxyacetone dimer and subsequent 1,2-addition of an acetylenic nucleophile has been discovered and optimized into the manufacturing process

scholarly journals The physical properties of supramolecular peptide assemblies: from building block association to technological applications

2014 ◽  
Vol 43 (20) ◽  
pp. 6881-6893 ◽  
Author(s):  
Lihi Adler-Abramovich ◽  
Ehud Gazit
Keyword(s):  
Drug Delivery ◽  
Energy Storage ◽  
Building Block ◽  
Building Blocks ◽  
Nano Materials ◽  
Energy Storage Devices ◽  
Storage Devices ◽  
Block Association ◽  
Ordered Assembly ◽  
Elementary Building

Bio-inspired nano-materials can be formed by the ordered assembly of elementary building blocks. These peptide nanostructures can be utilized in many applications in various fields ranging from energy storage devices to drug delivery agents.

The Photometric Properties of the Ap Stars

1976 ◽  
Vol 32 ◽  
pp. 365-377 ◽  
Author(s):  
B. Hauck
Keyword(s):  
Physical Properties ◽  
Ap Stars

The Ap stars are numerous - the photometric systems tool It would be very tedious to review in detail all that which is in the literature concerning the photometry of the Ap stars. In my opinion it is necessary to examine the problem of the photometric properties of the Ap stars by considering first of all the possibility of deriving some physical properties for the Ap stars, or of detecting new ones. My talk today is prepared in this spirit. The classification by means of photoelectric photometric systems is at the present time very well established for many systems, such as UBV, uvbyβ, Vilnius, Geneva and DDO systems. Details and methods of classification can be found in Golay (1974) or in the proceedings of the Albany Colloquium edited by Philip and Hayes (1975).

The Infection of Cells by Bullet-Shaped Viruses

1969 ◽  
Vol 27 ◽  
pp. 372-373
Author(s):  
Frederick A. Murphy ◽  
Alyne K. Harrison ◽  
Sylvia G. Whitfield
Keyword(s):  
Electron Microscopy ◽  
Physical Properties ◽  
Host Cell ◽  
Thin Section ◽  
Cultured Cells ◽  
Cell Infection ◽  
Thin Section Electron Microscopy ◽  
Section Electron ◽  
Section Electron Microscopy

The bullet-shaped viruses are currently classified together on the basis of similarities in virion morphology and physical properties. Biologically and ecologically the member viruses are extremely diverse. In searching for further bases for making comparisons of these agents, the nature of host cell infection, both in vivo and in cultured cells, has been explored by thin-section electron microscopy.

Transmission electron microscopy of composite materials

1988 ◽  
Vol 46 ◽  
pp. 1012-1015
Author(s):  
K.P.D. Lagerlof
Keyword(s):  
Composite Materials ◽  
Physical Properties ◽  
Structural Defects ◽  
Structural Composites ◽  
Multiphase Materials ◽  
Structural Reinforcement ◽  
Transmission Electron ◽  
Reinforced Fiber ◽  
Particulate Reinforced Composites ◽  
Definition Of

Although most materials contain more than one phase, and thus are multiphase materials, the definition of composite materials is commonly used to describe those materials containing more than one phase deliberately added to obtain certain desired physical properties. Composite materials are often classified according to their application, i.e. structural composites and electronic composites, but may also be classified according to the type of compounds making up the composite, i.e. metal/ceramic, ceramic/ceramie and metal/semiconductor composites. For structural composites it is also common to refer to the type of structural reinforcement; whisker-reinforced, fiber-reinforced, or particulate reinforced composites [1-4].For all types of composite materials, it is of fundamental importance to understand the relationship between the microstructure and the observed physical properties, and it is therefore vital to properly characterize the microstructure. The interfaces separating the different phases comprising the composite are of particular interest to understand. In structural composites the interface is often the weakest part, where fracture will nucleate, and in electronic composites structural defects at or near the interface will affect the critical electronic properties.

Physical Properties of Polymers

2004 ◽  
Author(s):  
James Mark ◽  
Kia Ngai ◽  
William Graessley ◽  
Leo Mandelkern ◽  
Edward Samulski ◽  
...  
Keyword(s):  
Physical Properties
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