scholarly journals Prospects for plasmonic hot spots in single molecule SERS towards the chemical imaging of live cells

2015 ◽  
Vol 17 (33) ◽  
pp. 21072-21093 ◽  
Author(s):  
Darya Radziuk ◽  
Helmuth Moehwald
Keyword(s):  
Single Molecule ◽  
Hot Spots ◽  
Chemical Imaging ◽  
Local Effect ◽  
Live Cells ◽  
Plasmonic Nanostructures ◽  
Surface Enhanced Raman ◽  
Sharp Edges ◽  
Enhanced Raman Scattering ◽  
Analyte Detection

Single molecule surface enhanced Raman scattering (SM-SERS) is a highly local effect occurring at sharp edges, interparticle junctions and crevices or other geometries with a sharp nanoroughness of plasmonic nanostructures (“hot spots”) for an analyte detection.

Probing the Structure of Single-Molecule Surface-Enhanced Raman Scattering Hot Spots

2008 ◽  
Vol 130 (38) ◽  
pp. 12616-12617 ◽  
Author(s):  
Jon P. Camden ◽  
Jon A. Dieringer ◽  
Yingmin Wang ◽  
David J. Masiello ◽  
Lawrence D. Marks ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Single Molecule ◽  
Hot Spots ◽  
Surface Enhanced Raman Scattering ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Molecule Surface

Tip enhanced Raman scattering: plasmonic enhancements for nanoscale chemical analysis

Nanophotonics ◽  
2014 ◽  
Vol 3 (1-2) ◽  
pp. 91-104 ◽  
Author(s):  
Zachary D. Schultz ◽  
James M. Marr ◽  
Hao Wang
Keyword(s):  
Chemical Analysis ◽  
Raman Scattering ◽  
Electric Fields ◽  
Single Molecule ◽  
Chemical Imaging ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Probe Microscope ◽  
Enhanced Raman Scattering ◽  
The Relationship

AbstractTip enhanced Raman scattering (TERS) is an emerging technique that uses a metalized scanning probe microscope tip to spatially localize electric fields that enhances Raman scattering enabling chemical imaging on nanometer dimensions. Arising from the same principles as surface enhanced Raman scattering (SERS), TERS offers unique advantages associated with controling the size, shape, and location of the enhancing nanostructure. In this article we discuss the correlations between current understanding of SERS and how this relates to TERS, as well as how TERS provides new understanding and insights. The relationship between plasmon resonances and Raman enhancements is emphasized as the key to obtaining optimal TERS results. Applications of TERS, including chemical analysis of carbon nanotubes, organic molecules, inorganic crystals, nucleic acids, proteins, cells and organisms, are used to illustrate the information that can be gained. Under ideal conditions TERS is capable of single molecule sensitivity and sub-nanometer spatial resolution. The ability to control plasmonic enhancements for chemical analysis suggests new experiments and opportunities to understand molecular composition and interactions on the nanoscale.

scholarly journals DNA origami based Au–Ag-core–shell nanoparticle dimers with single-molecule SERS sensitivity

Nanoscale ◽  
2016 ◽  
Vol 8 (10) ◽  
pp. 5612-5620 ◽  
Author(s):  
J. Prinz ◽  
C. Heck ◽  
L. Ellerik ◽  
V. Merk ◽  
I. Bald
Keyword(s):  
Raman Scattering ◽  
Single Molecule ◽  
Hot Spots ◽  
Dna Origami ◽  
Core Shell ◽  
Dye Molecules ◽  
Raman Enhancement ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

DNA origami nanostructures are used to arrange gold nanoparticles into dimers with defined distance, which can be exploited as novel substrates for surface enhanced Raman scattering (SERS). Single dye molecules (TAMRA and Cy3) can be placed into the SERS hot spots, with Raman enhancement up to 1010, which is sufficient to detect single molecules by Raman scattering.

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