scholarly journals Protection of DNA against low-energy electrons by amino acids: a first-principles molecular dynamics study

2014 ◽  
Vol 16 (44) ◽  
pp. 24350-24358 ◽  
Author(s):  
Bin Gu ◽  
Maeve Smyth ◽  
Jorge Kohanoff
Keyword(s):  
Molecular Dynamics ◽  
Amino Acids ◽  
Proton Transfer ◽  
First Principles ◽  
Low Energy ◽  
Energy Electron ◽  
Low Energy Electrons ◽  
Low Energy Electron ◽  
First Principles Molecular Dynamics

The physical shielding and chemical stabilizing of the low energy electron by glycine around the thymine through proton transfer.

First-principles molecular dynamics study of proton transfer mechanism in bovine cytochromecoxidase

2007 ◽  
Vol 19 (36) ◽  
pp. 365220 ◽  
Author(s):  
Katsumasa Kamiya ◽  
Mauro Boero ◽  
Masaru Tateno ◽  
Kenji Shiraishi ◽  
Atsushi Oshiyama
Keyword(s):  
Molecular Dynamics ◽  
Proton Transfer ◽  
First Principles ◽  
Transfer Mechanism ◽  
First Principles Molecular Dynamics

scholarly journals 5-Nitro-2,4-Dichloropyrimidine as an Universal Model for Low-Energy Electron Processes Relevant for Radiosensitization

2020 ◽  
Vol 21 (21) ◽  
pp. 8173
Author(s):  
Thomas F. M. Luxford ◽  
Stanislav A. Pshenichnyuk ◽  
Nail L. Asfandiarov ◽  
Tomáš Perečko ◽  
Martin Falk ◽  
...  
Keyword(s):  
Rational Design ◽  
Electron Attachment ◽  
Low Energy ◽  
Energy Electron ◽  
Model Molecule ◽  
Alternative Approach ◽  
Low Energy Electrons ◽  
Cluster Environment ◽  
Low Energy Electron ◽  
Low Solubility

We report experimental results of low-energy electron interactions with 5-nitro-2,4-dichloropyrimidine isolated in the gas phase and hydrated in a cluster environment. The molecule exhibits a very rare combination of many so far hypothesized low-energy electron induced mechanisms, which may be responsible for synergism in concurrent chemo-radiation therapy of cancer. In contrast to many previous efforts to design an ideal radiosensitizer based on one mode of action, the present model molecule presents an alternative approach, where several modes of action are combined. With respect to the processes induced by the low-energy electrons, this is not a trivial task because of strong bond specificity of the dissociative electron attachment reaction, as it is discussed in the present paper. Unfortunately, low solubility and high toxicity of the molecule, as obtained from preliminary MTT assay tests, do not enable further studies of its activity in real biological systems but it can advantageously serve as a model or a base for rational design of radiosensitizers.

Development of a Low Energy Electron Microscope with an Energy Analyzer

1998 ◽  
Vol 05 (06) ◽  
pp. 1199-1211 ◽  
Author(s):  
Y. Sakai ◽  
M. Kato ◽  
S. Masuda ◽  
Y. Harada ◽  
T. Ichinokawa
Keyword(s):  
Electron Microscope ◽  
Low Energy ◽  
Energy Electron ◽  
Energy Analyzer ◽  
Penning Ionization ◽  
Wien Filter ◽  
Low Energy Electrons ◽  
Filter Type ◽  
Low Energy Electron ◽  
Uv Photons

A low energy electron microscope (LEEM) with an energy analyzer of the Wien filter type was constructed for surface microanalyses and imaging by irradiating the specimen surface with several types of incident beams, e.g. low energy electrons, UV photons or metastable He * atoms. A retarding type Wien filter was used for the formation of electron energy filtered images and energy spectra of selected microareas by employing energy loss electron and Auger electron, photoelectron or Penning ionization spectroscopy. Several new designs and performances have been implemented in this instrument and are presented together with some applications.

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