A QM/MM study of Kemptide phosphorylation catalyzed by protein kinase A. The role of Asp166 as a general acid/base catalyst

2015 ◽  
Vol 17 (5) ◽  
pp. 3497-3511 ◽  
Author(s):  
Ayax Pérez-Gallegos ◽  
Mireia Garcia-Viloca ◽  
Àngels González-Lafont ◽  
José M. Lluch
Keyword(s):  
Protein Kinase ◽  
Proton Transfer ◽  
Protein Kinase A ◽  
Base Catalyst ◽  
Acid Base ◽  
General Acid ◽  
Kinase A

QM/MM calculations show that Asp166 is a general acid/base catalyst along the phosphoryl and proton transfer steps of Kemptide phosphorylation by protein kinase A.

Regulation of arginine vasopressin mRNA in rat fetal hypothalamic cell culture. Role of protein kinases and glucocorticoids

1993 ◽  
Vol 10 (1) ◽  
pp. 51-57 ◽  
Author(s):  
S-B Hu ◽  
L A Tannahill ◽  
S L Lightman
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Mrna Expression ◽  
Protein Kinase A ◽  
Arginine Vasopressin ◽  
In Situ Hybridization Histochemistry ◽  
Kinase C ◽  
Kinase A

ABSTRACT Studies have been performed to investigate the regulation of arginine vasopressin (AVP) mRNA expression in fetal hypothalamic cultures. AVP mRNA-positive neurones were identified by in-situ hybridization histochemistry, and changes in mRNA expression were quantitated by nuclease protection assay. Both protein kinase C and protein kinase A activators increased the expression of AVP mRNA, in contrast to dexamethasone, which inhibited the responses to both protein kinase C and protein kinase A activation.

scholarly journals Role of Calmodulin-Calmodulin Kinase II, cAMP/Protein Kinase A and ERK 1/2 on Aeromonas hydrophila-Induced Apoptosis of Head Kidney Macrophages

2014 ◽  
Vol 10 (4) ◽  
pp. e1004018 ◽  
Author(s):  
Chaitali Banerjee ◽  
Preeti Khatri ◽  
Rajagopal Raman ◽  
Himanshi Bhatia ◽  
Malabika Datta ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Aeromonas Hydrophila ◽  
Head Kidney ◽  
Calmodulin Kinase ◽  
Induced Apoptosis ◽  
Kinase A
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