Electronic effect of terminal acceptor groups on different organic donor–acceptor small-molecule based memory devices

2014 ◽  
Vol 16 (32) ◽  
pp. 17125-17132 ◽  
Author(s):  
Haifeng Liu ◽  
Hao Zhuang ◽  
Hua Li ◽  
Jianmei Lu ◽  
Lihua Wang

Three conjugated organic donor–acceptor small-molecules BCZ-BT, BCZ-NO2 and BCZ-CN with different electronic effects in their terminal acceptors were designed and synthesized and their application in memory devices with a sandwich configuration was tested.

2014 ◽  
Vol 118 (4) ◽  
pp. 2154-2160 ◽  
Author(s):  
Shifeng Miao ◽  
Yongxiang Zhu ◽  
Qing Bao ◽  
Hua Li ◽  
Najun Li ◽  
...  

2015 ◽  
Vol 3 (23) ◽  
pp. 5951-5957 ◽  
Author(s):  
Yu Jung Park ◽  
Jung Hwa Seo ◽  
Walaa Elsawy ◽  
Bright Walker ◽  
Shinuk Cho ◽  
...  

We have investigated the field-effect transistor characteristics of a series of isoindigo based donor–acceptor–donor small molecules via solvent additives.


2017 ◽  
Vol 8 (3) ◽  
pp. 2017-2024 ◽  
Author(s):  
Prabhat Gautam ◽  
Rahul Sharma ◽  
Rajneesh Misra ◽  
M. L. Keshtov ◽  
S. A. Kuklin ◽  
...  

Donor–acceptor–acceptor (D–A–A) type 1,8-naphthalimide based small molecules SM1 and SM2 functionalized with tetracyanobutadiene (TCBD) and dicyanoquino-dimethane (DCNQ) modules, showing strong absorption in the visible and near-infrared (NIR) region are reported.


2020 ◽  
Vol 8 (37) ◽  
pp. 12714-12738 ◽  
Author(s):  
Boyuan Mu ◽  
Hsiao-Hsuan Hsu ◽  
Chi-Ching Kuo ◽  
Su-Ting Han ◽  
Ye Zhou

Recent state-of-the-art developments related to organic small molecules for resistive random-access memory devices has been emphasized.


2021 ◽  
Vol 1198 ◽  
pp. 113176
Author(s):  
Sadaf Bibi ◽  
Rasheed Ahmad Khera ◽  
Afifa Farhat ◽  
Javed Iqbal

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii200-ii200
Author(s):  
Stephen Skirboll ◽  
Natasha Lucki ◽  
Genaro Villa ◽  
Naja Vergani ◽  
Michael Bollong ◽  
...  

Abstract INTRODUCTION Glioblastoma multiforme (GBM) is the most aggressive form of primary brain cancer. A subpopulation of multipotent cells termed GBM cancer stem cells (CSCs) play a critical role in tumor initiation and maintenance, drug resistance, and recurrence following surgery. New therapeutic strategies for the treatment of GBM have recently focused on targeting CSCs. Here we have used an unbiased large-scale screening approach to identify drug-like small molecules that induce apoptosis in GBM CSCs in a cell type-selective manner. METHODS A luciferase-based survival assay of patient-derived GBM CSC lines was established to perform a large-scale screen of ∼one million drug-like small molecules with the goal of identifying novel compounds that are selectively toxic to chemoresistant GBM CSCs. Compounds found to kill GBM CSC lines as compared to control cell types were further characterized. A caspase activation assay was used to evaluate the mechanism of induced cell death. A xenograft animal model using patient-derived GBM CSCs was employed to test the leading candidate for suppression of in vivo tumor formation. RESULTS We identified a small molecule, termed RIPGBM, from the cell-based chemical screen that induces apoptosis in primary patient-derived GBM CSC cultures. The cell type-dependent selectivity of RIPGBM appears to arise at least in part from redox-dependent formation of a proapoptotic derivative, termed cRIPGBM, in GBM CSCs. cRIPGBM induces caspase 1-dependent apoptosis by binding to receptor-interacting protein kinase 2 (RIPK2) and acting as a molecular switch, which reduces the formation of a prosurvival RIPK2/TAK1 complex and increases the formation of a proapoptotic RIPK2/caspase 1 complex. In an intracranial GBM xenograft mouse model, RIPGBM was found to significantly suppress tumor formation. CONCLUSIONS Our chemical genetics-based approach has identified a small molecule drug candidate and a potential drug target that selectively targets cancer stem cells and provides an approach for the treatment of GBMs.


2015 ◽  
Vol 7 (18) ◽  
pp. 7879-7888 ◽  
Author(s):  
Jiafei Wang ◽  
Xiaoya Jiang ◽  
Hang Zhang ◽  
Sha Liu ◽  
Ligai Bai ◽  
...  

A monolith based on an ionic liquid as a porogen was prepared to enhance the column efficiency of small molecule separation in HPLC.


Sign in / Sign up

Export Citation Format

Share Document