scholarly journals Tetrazoles: calcium oxalate crystal growth modifiers

CrystEngComm ◽  
2015 ◽  
Vol 17 (13) ◽  
pp. 2675-2681 ◽  
Author(s):  
Calum J. McMulkin ◽  
Massimiliano Massi ◽  
Franca Jones
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Calcium Oxalate Crystal ◽  
Calcium Oxalate Crystallization

Metabolically stable tetrazole molecules are shown to impact calcium oxalate crystallization, thus tetrazoles can be used in investigating biological crystallization processes.

Exploring the Molecular Level Interaction of Human Serum Albumin with Calcium Oxalate Monohydrate Crystals

2021 ◽  
Vol 28 ◽  
Author(s):  
Priyadarshini ◽  
Abhishek Negi ◽  
Chetna Faujdar ◽  
Lokesh Nigam ◽  
Naidu Subbarao
Keyword(s):  
Amino Acids ◽  
Crystal Growth ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Calcium Oxalate ◽  
Human Serum ◽  
Stone Formation ◽  
Calcium Oxalate Monohydrate ◽  
Calcium Oxalate Crystallization ◽  
In Silico Docking

Background: Human serum albumin (HSA) is one of the most abundant proteins in the blood plasma, urine as well as in the organic matrix of renal calculi. Macromolecules present in the urine modulate kidney stone formation either by stimulating or inhibiting crystallization process. Objective: In the present study, effect of HSA protein on the growth of calcium oxalate monohydrate crystal (COM) was investigated. Methods: Crystal growth assay was used to measure oxalate depletion in the crystal seeded solution in the presence of HSA. HSA concentrations exhibiting effect on crystal growth were selected for FTIR and XRD analysis. In silico docking was performed on seven different binding sites of HSA. Results: Albumin is playing dual role in growth of calcium oxalate crystallization. FTIR and XRD studies further revealed HSA exerted strain over crystal thus affecting its structure by interacting with amino acids of its pocket 1. Docking results indicate that out of 7 binding pocket in protein, calcium oxalate interacts with Arg-186 and Lys-190 amino acids of pocket 1. Conclusion: Our study confirms the role of HSA in calcium oxalate crystallization where acidic amino acids arginine and lysine are binding with COM crystals, revealing molecular interaction of macromolecule and crystal in urolithiasis.

Bacteria can promote calcium oxalate crystal growth and aggregation

2013 ◽  
Vol 18 (3) ◽  
pp. 299-308 ◽  
Author(s):  
Somchai Chutipongtanate ◽  
Suchitra Sutthimethakorn ◽  
Wararat Chiangjong ◽  
Visith Thongboonkerd
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Calcium Oxalate Crystal

Mannan-binding lectin (MBL)-associated plasma protein present in human urine inhibits calcium oxalate crystal growth

FEBS Letters ◽  
1999 ◽  
Vol 462 (1-2) ◽  
pp. 89-93 ◽  
Author(s):  
Insug Kang ◽  
Jin-Il Kim ◽  
Sung-Goo Chang ◽  
Sun-Ju Lee ◽  
Sang-Lim Choi ◽  
...  
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Plasma Protein ◽  
Human Urine ◽  
Calcium Oxalate Crystal ◽  
Mannan Binding Lectin ◽  
Binding Lectin

An unidentified macromolecular inhibitory constituent of calcium oxalate crystal growth in human urine

1990 ◽  
Vol 18 (6) ◽  
pp. 373-379 ◽  
Author(s):  
S. S�rensen ◽  
K. Hansen ◽  
S. Bak ◽  
S. J. Justesen
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Human Urine ◽  
Calcium Oxalate Crystal

Urinary Trefoil Factor 1 is a Novel Potent Inhibitor of Calcium Oxalate Crystal Growth and Aggregation

2008 ◽  
Vol 179 (4) ◽  
pp. 1615-1619 ◽  
Author(s):  
Visith Thongboonkerd ◽  
Somchai Chutipongtanate ◽  
Theptida Semangoen ◽  
Prida Malasit
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Potent Inhibitor ◽  
Trefoil Factor ◽  
Calcium Oxalate Crystal ◽  
Trefoil Factor 1
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