Supramolecular cyclodextrin-based drug nanocarriers

2015 ◽  
Vol 51 (29) ◽  
pp. 6275-6289 ◽  
Author(s):  
Susana M. N. Simões ◽  
Ana Rey-Rico ◽  
Angel Concheiro ◽  
Carmen Alvarez-Lorenzo
Keyword(s):  
Stimuli Responsive ◽  
Drug Conjugates ◽  
Drug Nanocarriers

Hosting of polymers, lipids and drug conjugates makes cyclodextrins suitable to prepare biocompatible, targetable and stimuli-responsive supramolecular drug nanocarriers.

Stimuli-responsive phospholipid-drug conjugates (PDCs)-based nanovesicles for drug delivery and theranostics

2020 ◽  
Vol 590 ◽  
pp. 119920
Author(s):  
Jiang Yu ◽  
Ying Liu ◽  
Shuang Zhou ◽  
Yingli Wang ◽  
Yongjun Wang
Keyword(s):  
Drug Delivery ◽  
Stimuli Responsive ◽  
Drug Conjugates

Molecularly Engineered Polymer-Based Systems in Drug Delivery and Regenerative Medicine

2017 ◽  
Vol 23 (2) ◽  
pp. 281-294 ◽  
Author(s):  
Susanna Piluso ◽  
Al Halifa Soultan ◽  
Jennifer Patterson
Keyword(s):  
Drug Delivery ◽  
Regenerative Medicine ◽  
Local Environment ◽  
Stimuli Responsive ◽  
Controlled Polymerization ◽  
Polymer Therapeutics ◽  
Protein Conjugates ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Drug Conjugates

Background: Polymer-based systems are attractive in drug delivery and regenerative medicine due to the possibility of tailoring their properties and functions to a specific application. Methods: The present review provides several examples of molecularly engineered polymer systems, including stimuli responsive polymers and supramolecular polymers. Results: The advent of controlled polymerization techniques has enabled the preparation of polymers with controlled molecular weight and well-defined architecture. By using these techniques coupled to orthogonal chemical modification reactions, polymers can be molecularly engineered to incorporate functional groups able to respond to small changes in the local environment or to a specific biological signal. This review highlights the properties and applications of stimuli-responsive systems and polymer therapeutics, such as polymer-drug conjugates, polymer-protein conjugates, polymersomes, and hyperbranched systems. The applications of polymeric membranes in regenerative medicine are also discussed. Conclusion: The examples presented in this review suggest that the combination of membranes with polymers that are molecularly engineered to respond to specific biological functions could be relevant in the field of regenerative medicine.

scholarly journals Development of Diazaborines as ROS Sensitive Linkers for the Construction of Stimuli-Responsive Antibody Drug Conjugates

2021 ◽  
Author(s):  
Pedro Gois ◽  
João António ◽  
Joana Carvalho ◽  
Ana André ◽  
Joana Dias ◽  
...  
Keyword(s):  
Stimuli Responsive ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Antibody Drug

scholarly journals Stimuli-responsive star poly(ethylene glycol) drug conjugates for improved intracellular delivery of the drug in neuroinflammation

2010 ◽  
Vol 142 (3) ◽  
pp. 447-456 ◽  
Author(s):  
Raghavendra S. Navath ◽  
Bing Wang ◽  
Sujatha Kannan ◽  
Roberto Romero ◽  
Rangaramanujam M. Kannan
Keyword(s):  
Ethylene Glycol ◽  
Intracellular Delivery ◽  
Stimuli Responsive ◽  
Poly Ethylene Glycol ◽  
Drug Conjugates ◽  
Poly Ethylene

Amino-functional polyethers: versatile, stimuli-responsive polymers

2020 ◽  
Vol 11 (24) ◽  
pp. 3940-3950 ◽  
Author(s):  
Patrick Verkoyen ◽  
Holger Frey
Keyword(s):  
Ring Opening ◽  
Review Article ◽  
Stimuli Responsive ◽  
New Class ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers

Amino-functional polyethers have emerged as a new class of “smart”, i.e. pH- and thermoresponsive materials. This review article summarizes the synthesis and applications of these materials, obtained from ring-opening of suitable epoxide monomers.

ASCO-GU 2019: Metastasierte Urothelkarzinome

2019 ◽  
Vol 10 (03) ◽  
pp. 140-141
Author(s):  
Alexander Kretzschmar
Keyword(s):  
San Francisco ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Chapel Hill ◽  
Antibody Drug

Die Therapielandschaft des metastasierten Urothelkarzinoms hat sich seit der Zulassung der ersten Immun-Checkpoint-Inhibitoren verändert. Die neuen Therapien sind deutlich effektiver, allerdings erreichen die Responseraten der neuen Therapien nur bis zu etwa 30 %, beklagte Prof. Matthew Milowsky, Chapel Hill/USA, auf einer Oral Abstract Session auf dem ASCO-GU. In San Francisco gaben erste Vorträge und Poster bereits einen Einblick, wovon diejenigen Patienten profitieren könnten, die auf die etablierten Chemotherapien und die neuen Immuntherapien nicht ansprechen. Manche Onkologen sprechen bereits von der „Post-Checkpoint-Ära”. Als Kandidaten werden vor allem Antikörper-Wirkstoff-Konjugate (antibody-drug conjugates; ADC) gehandelt – und zwar nicht nur zur Therapie des metastasierten Blasenkarzinoms.

4D printing technology, modern era: A short review

2020 ◽  
pp. 92-111
Author(s):  
Khodadad Mostakim ◽  
Nahid Imtiaz Masuk ◽  
Md. Rakib Hasan ◽  
Md. Shafikul Islam
Keyword(s):  
Smart Materials ◽  
Computer Aided Design ◽  
Short Review ◽  
Stimuli Responsive ◽  
4D Printing ◽  
Space Applications ◽  
Printing Technology ◽  
Practical Applications ◽  
Biomedical Technologies ◽  
Novel Material

The advancement in 3D printing has led to the rapid growth of 4D printing technology. Adding time, as the fourth dimension, this technology ushered the potential of a massive evolution in fields of biomedical technologies, space applications, deployable structures, manufacturing industries, and so forth. This technology performs ingenious design, using smart materials to create advanced forms of the 3-D printed specimen. Improvements in Computer-aided design, additive manufacturing process, and material science engineering have ultimately favored the growth of 4-D printing innovation and revealed an effective method to gather complex 3-D structures. Contrast to all these developments, novel material is still a challenging sector. However, this short review illustrates the basic of 4D printing, summarizes the stimuli responsive materials properties, which have prominent role in the field of 4D technology. In addition, the practical applications are depicted and the potential prospect of this technology is put forward.

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