Copper-catalyzed radical cascade cyclization for the synthesis of phosphorated indolines

2015 ◽  
Vol 51 (19) ◽  
pp. 4101-4104 ◽  
Author(s):  
Hong-Yu Zhang ◽  
Liu-Liang Mao ◽  
Bin Yang ◽  
Shang-Dong Yang
Keyword(s):  
Cyclization Reaction ◽  
Cascade Cyclization ◽  
Convenient Approach ◽  
Radical Cascade

A novel and convenient approach to the synthesis of various phosphorated indolines via a copper-catalyzed radical cascade cyclization reaction has been developed.

Direct synthesis of 4-hydroxycoumarins and 4-hydroxy-6-methyl-2-pyrone containing chroman-4-ones via silver catalyzed radical cascade cyclization reaction

2021 ◽  
Author(s):  
Suraj Sharma ◽  
Bipul Sarma ◽  
Gakul Baishya
Keyword(s):  
Direct Synthesis ◽  
Cyclization Reaction ◽  
Cascade Cyclization ◽  
Radical Cascade ◽  
First Time

For the first time, we report a novel silver catalyzed radical cascade cyclization reaction of 2-(allyloxy)arylaldehydes to synthesize two new libraries of chroman-4-ones by using 4-hydroxycoumarins and 4-hydroxy-6-methyl-2-pyrone as radical...

Radical Cascade Cyclization: Reaction of 1,6-Enynes with Aryl Radicals by Electron Catalysis

2016 ◽  
Vol 2016 (29) ◽  
pp. 4961-4964 ◽  
Author(s):  
Jun Xuan ◽  
Dario Gonzalez-Abradelo ◽  
Cristian Alejandro Strassert ◽  
Constantin-Gabriel Daniliuc ◽  
Armido Studer
Keyword(s):  
Cyclization Reaction ◽  
Cascade Cyclization ◽  
Aryl Radicals ◽  
Radical Cascade

Fe-Catalyzed Conjunctive Cross-Couplings of Unactivated Alkenes with Grignard Reagents

2020 ◽  
Author(s):  
Lei Liu ◽  
Wes Lee ◽  
Cassandra R. Youshaw ◽  
Mingbin Yuan ◽  
Michael B. Geherty ◽  
...  
Keyword(s):  
Functional Groups ◽  
Cross Coupling ◽  
Alkyl Halides ◽  
Grignard Reagents ◽  
Turnover Frequency ◽  
Diverse Range ◽  
Cascade Cyclization ◽  
Radical Cascade

The first iron-catalyzed three-component cross-coupling of unactivated olefins with alkyl halides and Grignard reagents is reported. The reaction operates under fast turnover frequency and tolerates a diverse range of sp2-hybridized nucleophiles, alkyl halides, and unactivated olefins bearing diverse functional groups to yield the desired 1,2-alkylarylated products with high regiocontrol. Further, we demonstrate that this protocol is amenable for the synthesis of new (hetero)carbocycles including tetrahydrofurans and pyrrolidines via a three-component radical cascade cyclization/arylation that forges three new C-C bonds.

Eosin Y photoredox catalyzed net redox neutral reaction for regiospecific annulation to 3-sulfonylindoles via anion oxidation of sodium sulfinate salts

2018 ◽  
Vol 16 (4) ◽  
pp. 536-540 ◽  
Author(s):  
Rajendra S. Rohokale ◽  
Shrikant D. Tambe ◽  
Umesh A. Kshirsagar
Keyword(s):  
Visible Light ◽  
Eosin Y ◽  
Cascade Cyclization ◽  
Neutral Reaction ◽  
Neutral Process ◽  
Radical Cascade

An eosin Y photoredox catalyzed net redox neutral process for 3-sulfonylindoles via the anionic oxidation of sodium sulfinate salts and its radical cascade cyclization with 2-alkynyl-azidoarenes was developed with visible light as a mediator.

ChemInform Abstract: Superbase-Promoted Selective Cascade Cyclization Reaction of 1,5-Diketones with Acetylenes to Methylene-6,8-dioxabicyclo[3.2.1]octanes.

ChemInform ◽  
2013 ◽  
Vol 44 (37) ◽  
pp. no-no
Author(s):  
Elena Yu. Schmidt ◽  
Ivan A. Bidusenko ◽  
Nadezhda I. Protsuk ◽  
Igor A. Ushakov ◽  
Boris A. Trofimov
Keyword(s):  
Cyclization Reaction ◽  
Cascade Cyclization

Iron-catalyzed radical cascade cyclization of oxime esters with isocyanides: synthesis of 1-cyanoalkyl isoquinolines and 6-cyanoalkyl phenanthridines

2021 ◽  
Vol 19 (39) ◽  
pp. 8597-8606
Author(s):  
Dengqi Xue ◽  
Rongqi Liu ◽  
Denggao Zhang ◽  
Ning Li ◽  
Yijie Xue ◽  
...  
Keyword(s):  
Cascade Cyclization ◽  
Radical Cascade

An iron-catalyzed radical cascade cyclization of oxime esters with isocyanides for the synthesis of 1-cyanoalkyl isoquinolines and 6-cyanoalkyl phenanthridines has been developed.

Catalytic Radical Cascade Cyclization of Alkene-Tethered Enones to Fused Bicyclic Cyclopropanols

2021 ◽  
Author(s):  
Ying Xie ◽  
Wei Huang ◽  
Song Qin ◽  
Shaomin Fu ◽  
Bo Liu
Keyword(s):  
Hydrogen Atom ◽  
Cascade Reaction ◽  
Hydrogen Atom Transfer ◽  
Atom Transfer ◽  
Trimethyl Borate ◽  
Cascade Cyclization ◽  
Radical Cascade ◽  
Privileged Scaffolds

An unprecedented hydrogen atom transfer-triggered intramolecular cascade reaction between alkene and enone is developed, using Fe(acac)3, PhSiH2(Oi-Pr) and trimethyl borate, to efficiently construct cis-fused bicyclic cyclopropanols, privileged scaffolds often found...

Electrochemical oxidative radical cascade cyclization of olefinic amides and thiophenols towards the synthesis of sulfurated benzoxazines, oxazolines and iminoisobenzofurans

2021 ◽  
Author(s):  
Fangling Lu ◽  
Jie Xu ◽  
Hao Li ◽  
Ke Wang ◽  
Dandan Ouyang ◽  
...  
Keyword(s):  
Cascade Cyclization ◽  
Radical Cascade

Heterocycles containing N and O are important structures in pharmaceuticals, agrochemicals and functional molecules.

Copper-catalyzed radical cascade cyclization of 2-(allyloxy)arylaldehydes towards chroman-4-one derivatives

2021 ◽  
pp. 153605
Author(s):  
Wenbin Guo ◽  
Linlin Gui ◽  
Xin Chen ◽  
Zhijun Dai ◽  
Liping Wang ◽  
...  
Keyword(s):  
Cascade Cyclization ◽  
Radical Cascade

Diverse privileged N-polycyclic skeletons accessed from a metal-free cascade cyclization reaction

2021 ◽  
Vol 19 (37) ◽  
pp. 8086-8095
Author(s):  
Wenzhong Li ◽  
Yu Wang ◽  
Huijing Qi ◽  
Ran Shi ◽  
Jiazhu Li ◽  
...  
Keyword(s):  
Membered Ring ◽  
Cyclization Reaction ◽  
One Pot ◽  
Metal Free ◽  
Cascade Cyclization ◽  
One Pot Synthesis ◽  
Ring Compounds

Metal-free cascade cyclization of 2-acylbenzoic acids with amines provided a one-pot synthesis of diverse isoindoloisoquinoline and benzoindolizinoindole derivatives, which were subsequently used to produce nitrogen-containing nine-membered ring compounds.

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