scholarly journals Organocatalytic one-pot 1,4-/1,6-/1,2-addition sequence for the stereocontrolled formation of six consecutive stereocenters

2015 ◽  
Vol 51 (12) ◽  
pp. 2270-2272 ◽  
Author(s):  
Pankaj Chauhan ◽  
Suruchi Mahajan ◽  
Gerhard Raabe ◽  
Dieter Enders
Keyword(s):  
Addition Reaction ◽  
One Pot ◽  
Stereogenic Centers

A new stereoselective organocatalyzed one-pot 1,4-/1,6-/1,2-addition reaction sequentially catalyzed by low loading of a squaramide and an achiral base provide a direct entry to isoxazole bearing cyclohexanes with six contiguous stereogenic centers in good yields and excellent stereoselectivities.

Efficient Synthesis of 3-Amino-1,5-benzodiazepine-2-one Derivatives

Synlett ◽  
2017 ◽  
Vol 28 (10) ◽  
pp. 1183-1186 ◽  
Author(s):  
Nobuhiro Obara ◽  
Takeshi Watanabe ◽  
Tomohiro Asakawa ◽  
Toshiyuki Kan ◽  
Takao Tanaka
Keyword(s):  
Michael Addition ◽  
Convenient Method ◽  
Addition Reaction ◽  
Efficient Synthesis ◽  
Michael Addition Reaction ◽  
One Pot ◽  
Simple Method ◽  
The Michael Addition

A convenient method for synthesizing 3-amino-1,5-benzodiazepine-2-one via the Michael addition reaction of o-phenylenediamine with dehydroalanine ester derivatives, followed by cyclization, was developed. This simple method was used to obtain a variety of N-substituted 3-amino-1,5-benzodiazepine-2-ones in one pot with good yields.

Access to 3-Arylindoles through a Tandem One-Pot Protocol Involving Dearomatization, a Regioselective Michael Addition Reaction, and Rearomatization

2014 ◽  
Vol 2014 (12) ◽  
pp. 2565-2575 ◽  
Author(s):  
Santhosh Kumar Chittimalla ◽  
Chennakesavulu Bandi ◽  
Sireesha Putturu ◽  
Rajesh Kuppusamy ◽  
Kevin Christopher Boellaard ◽  
...  
Keyword(s):  
Michael Addition ◽  
Addition Reaction ◽  
Michael Addition Reaction ◽  
One Pot

Bi(OTf)3-Catalyzed Diastereoselective One-Pot Synthesis of 1,3-Diamines with Three Continuous Stereogenic Centers

2018 ◽  
Vol 83 (19) ◽  
pp. 12007-12022 ◽  
Author(s):  
Juliette Halli ◽  
Philipp Kramer ◽  
Jennifer Grimmer ◽  
Michael Bolte ◽  
Georg Manolikakes
Keyword(s):  
One Pot ◽  
One Pot Synthesis ◽  
Stereogenic Centers

Stereocontrolled construction of six vicinal stereogenic centers on a hexahydroxanthone framework through a formal [2+1+3] annulation

2019 ◽  
Vol 55 (93) ◽  
pp. 14003-14006 ◽  
Author(s):  
Shun-Qin Chang ◽  
Xiong Zou ◽  
Yi Gong ◽  
Xue-Wen He ◽  
Xiong-Li Liu ◽  
...  
Keyword(s):  
Michael Addition ◽  
One Pot ◽  
Stereogenic Centers

The first example of a bifunctional donor–donor 3C synthon formed in situ from an activated methine with nitromethane through a [2+1] Michael addition, further directing a one-pot organocascade Michael/Henry cycloaddition was developed.

ChemInform Abstract: Recyclable Organocatalyst-Promoted One-Pot Michael/Aza-Henry/Lactamization Reactions for Fluorinated 2-Piperidinones Bearing Four Stereogenic Centers.

ChemInform ◽  
2016 ◽  
Vol 47 (4) ◽  
pp. no-no
Author(s):  
Xin Huang ◽  
Kenny Pham ◽  
Xiaofeng Zhang ◽  
Wen-Bin Yi ◽  
Jeremy H. Hyatt ◽  
...  
Keyword(s):  
One Pot ◽  
Stereogenic Centers

One-Pot Asymmetric Synthesis of β-Cyanohydroxymethyl α-Amino Acid Derivatives:  Formation of Three Contiguous Stereogenic Centers

2002 ◽  
Vol 4 (25) ◽  
pp. 4519-4522 ◽  
Author(s):  
Shin-ichi Watanabe ◽  
Armando Córdova ◽  
Fujie Tanaka ◽  
Carlos F. Barbas
Keyword(s):  
Amino Acid ◽  
Asymmetric Synthesis ◽  
Amino Acid Derivatives ◽  
One Pot ◽  
Stereogenic Centers

scholarly journals Hydrosilylation of Reactive Quantum Dots and Siloxanes for Stable Quantum Dot Films

Polymers ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 905
Author(s):  
Changmin Lee ◽  
Eunhee Nam ◽  
Woosuk Lee ◽  
Heeyeop Chae
Keyword(s):  
Quantum Dots ◽  
Oleic Acid ◽  
Nucleophilic Addition ◽  
Addition Reaction ◽  
Light Emitting Diode ◽  
Molecular Structures ◽  
One Pot ◽  
Nucleophilic Addition Reaction ◽  
The Stability ◽  
Photo Stability

The reactive acrylate-terminated CdZnSeS/ZnS quantum dots (QDs) were designed and prepared by the effective synthetic route to bond with a siloxane matrix via hydrosilylation. The conventional QD with oleic acid ligands does not have any reactivity, so the QDs were functionalized to assign reactivity for the QDs by the ligand modification of two step reactions. The oleic acid of the QDs was exchanged for hydroxyl-terminated ligands as an intermediate product by one-pot reaction. The hydroxyl-terminated QDs and acrylate-containing isocyanates were combined by nucleophilic addition reaction with forming urethane bonds and terminal acrylate groups. No degradation in quantum yield was observed after ligand exchange, nor following the nucleophilic addition reaction. The modification reactions of ligands were quantitatively controlled and their molecular structures were precisely confirmed by FT-IR and 1H-NMR. The QDs with acrylate ligands were then reacted with hydride-terminated polydimethylsiloxane (H-PDMS) to form a QD-siloxane matrix by thermal curing via hydro-silylation for the first time. The covalent bonding between the QDs and the siloxane matrix led to improvements in the stability against oxygen and moisture. Stability at 85 °C and 85% relative humidity (RH) were both improved by 22% for the QD-connected siloxane QD films compared with the corresponding values for conventional QD-embedded poly(methylmethacrylate) (PMMA) films. The photo-stability of the QD film after 26 h under a blue light-emitting diode (LED) was also improved by 45% in comparison with those of conventional QD-embedded PMMA films.

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