An organocatalytic Michael-cyclization cascade of 4-oxa-α,β-unsaturated carboxylic acids with aldehydes: facile synthesis of chiral γ-lactols and trisubstituted γ-lactones

2015 ◽  
Vol 51 (17) ◽  
pp. 3596-3599 ◽  
Author(s):  
Jun-Bing Lin ◽  
Shi-Ming Xu ◽  
Ji-Kang Xie ◽  
Hong-Yu Li ◽  
Peng-Fei Xu
Keyword(s):  
Carboxylic Acids ◽  
Enantioselective Synthesis ◽  
Facile Synthesis ◽  
Unsaturated Carboxylic Acids

An organocatalytic Michael-cyclization cascade of 4-oxa-α,β-unsaturated carboxylic acids with aldehydes has been developed, enabling highly enantioselective synthesis of γ-lactols, trisubstituted γ-lactones and γ-lactams.

N-Heterocyclic Carbene Catalyzed Cyclocondensation of α,β-Unsaturated Carboxylic Acids: Enantioselective Synthesis of Pyrrolidinone and Dihydropyridinone Derivatives

2014 ◽  
Vol 126 (43) ◽  
pp. 11795-11799 ◽  
Author(s):  
Xiang-Yu Chen ◽  
Zhong-Hua Gao ◽  
Chun-Yu Song ◽  
Chun-Lin Zhang ◽  
Zhi-Xiang Wang ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Enantioselective Synthesis ◽  
Unsaturated Carboxylic Acids

N-Heterocyclic carbene-catalyzed [4 + 2] cyclization of α,β-unsaturated carboxylic acids bearing γ-H with isatins: an enantioselective synthesis of spirocyclic oxindole–dihydropyranones

2016 ◽  
Vol 14 (4) ◽  
pp. 1485-1491 ◽  
Author(s):  
Ling Zhu ◽  
Chenxia Yu ◽  
Tuanjie Li ◽  
Yuhong Wang ◽  
Yinan Lu ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Enantioselective Synthesis ◽  
Unsaturated Carboxylic Acids ◽  
Spirocyclic Oxindole

An NHC-catalyzed asymmetric [4 + 2] annulation of isatins and α,β-unsaturated carboxylic acids bearing γ-H gave spirocyclic oxindole–dihydropyranones successfully via an in situ activation strategy.

N-Heterocyclic carbene-catalyzed [4 + 2] annulation of α,β-unsaturated carboxylic acids: enantioselective synthesis of dihydropyridinones and spirocyclic oxindolodihydropyridinones

2016 ◽  
Vol 3 (1) ◽  
pp. 77-81 ◽  
Author(s):  
Wen-Qiang Jia ◽  
Han-Ming Zhang ◽  
Chun-Lin Zhang ◽  
Zhong-Hua Gao ◽  
Song Ye
Keyword(s):  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Enantioselective Synthesis ◽  
Unsaturated Carboxylic Acid ◽  
Unsaturated Carboxylic Acids

The N-heterocyclic carbene-catalyzed [4 + 2] annulation of α,β-unsaturated carboxylic acid with hydrazones and isatin-derived imines was developed, affording the corresponding dihydropyridinones, respectively, in good yields with high enantioselectivities.

Sign in / Sign up

Export Citation Format

Share Document