Chiral recognition of Arg based on label-free PET nanochannel

2015 ◽  
Vol 51 (23) ◽  
pp. 4823-4826 ◽  
Author(s):  
Zhongyue Sun ◽  
Fan Zhang ◽  
Xiaoyan Zhang ◽  
Demei Tian ◽  
Lei Jiang ◽  
...  
Keyword(s):  
Chiral Recognition ◽  
Chiral Selector ◽  
Label Free ◽  
Enantioselective Recognition

A label-free nanochannel for enantioselective recognition of d-, l-Arg by adding BSA as chiral selector has been fabricated. Before adding BSA, the nanochannel cannot discriminate d- and l-Arg while with addition of BSA, this nanochannel displayed good enantioselectivity.

Enantioselective Recognition of Chiral Guests by the Water-Soluble Chiral Keplerate {Mo132} Spherical Capsule with 30 Inner Lactate Ligands

2019 ◽  
Author(s):  
Nancy Watfa ◽  
Weimin Xuan ◽  
Zoe Sinclair ◽  
Robert Pow ◽  
Yousef Abul-Haija ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Chiral Recognition ◽  
Association Constants ◽  
Water Soluble ◽  
Enantioselective Recognition ◽  
H Nmr ◽  
Dosy Nmr ◽  
Spherical Capsule ◽  
Surface Pores ◽  
Guest Chemistry

Investigations of chiral host guest chemistry are important to explore recognition in confined environments. Here, by synthesizing water-soluble chiral porous nanocapsule based on the inorganic metal-oxo Keplerate-type cluster, {Mo<sub>132</sub>} with chiral lactate ligands with the composition [Mo<sub>132</sub>O<sub>372</sub>(H<sub>2</sub>O)<sub>72</sub>(<i>x-</i>Lactate)<sub>30</sub>]<sup>42-</sup> (<i>x</i> = D or L), it was possible to study the interaction with a chiral guest, L/D-carnitine and (<i>R</i>/<i>S</i>)-2-butanol in aqueous solution. The enantioselective recognition was studied by quantitative <sup>1</sup>H NMR and <sup>1</sup>H DOSY NMR which highlighted that the chiral recognition is regulated by two distinct sites. Differences in the association constants (K) of L- and D-carnitine, which, due to their charge, are generally restricted from entering the interior of the host, are observed, indicating that their recognition predominantly occurs at the surface pores of the structure. Conversely, a larger difference in association constants (K<i><sub>S</sub></i>/K<i><sub>R</sub></i> = 3) is observed for recognition within the capsule interior of (<i>R</i>)- and (<i>S</i>)-2-butanol.

scholarly journals Correction: Label-free non-invasive fluorescent pattern discrimination of thiols and chiral recognition of cysteine enantiomers in biofluids using a bioinspired copolymer–Cu2+ hybrid sensor array regulated by pH

2019 ◽  
Vol 7 (37) ◽  
pp. 5732-5732
Author(s):  
Zi-Yang Lin ◽  
Xin-Yue Han ◽  
Zi-Han Chen ◽  
Guoyue Shi ◽  
Min Zhang
Keyword(s):  
Chiral Recognition ◽  
Sensor Array ◽  
Pattern Discrimination ◽  
Label Free ◽  
Non Invasive ◽  
Fluorescent Pattern

Correction for ‘Label-free non-invasive fluorescent pattern discrimination of thiols and chiral recognition of cysteine enantiomers in biofluids using a bioinspired copolymer–Cu2+ hybrid sensor array regulated by pH’ by Zi-Yang Lin et al., J. Mater. Chem. B, 2018, 6, 6877–6883.

scholarly journals HR-DOSY and sulfoxide enantiomeric discrimination by cyclodextrin

2000 ◽  
Vol 14 (4) ◽  
pp. 203-213 ◽  
Author(s):  
Ricardo Batista Borges ◽  
Antonio Laverde Jr. ◽  
André Luiz Meleiro Porto ◽  
Anita Jocelyne Marsaioli
Keyword(s):  
Chiral Recognition ◽  
Chemical Shifts ◽  
Binding Constants ◽  
Chiral Selector ◽  
Point Of View ◽  
The Other ◽  
Stoichiometric Ratio ◽  
Enantiomeric Resolution ◽  
Rp Hplc ◽  
C Nmr

Racemic and chiral ethyl-phenylsulfoxide (solute) andβ-cyclodextrin (chiral selector) were used to compare two NMR methodologies to predict RP-HPLC enantiomeric resolution efficiency. One of them based on the classical approach involving apparent binding constants and complexation‒induced chemical shifts at saturation and the other based on13C NMR signal splittings (solute and chiral selector in stoichiometric ratio) and HR-DOSY of the same solution. We have concluded that the latter methodology is rather efficient and though more elaborate from the NMR point of view, the results are promising and constitute an alternative method to investigate chiral recognition and other supramolecular phenomena.

Enantioseparation of mandelic acid and α-cyclohexylmandelic acid using an alcohol/salt-based aqueous two-phase system

2014 ◽  
Vol 68 (11) ◽  
Author(s):  
Fen-Fang Li ◽  
Zhi-Jian Tan ◽  
Zhi-Feng Guo
Keyword(s):  
Mandelic Acid ◽  
Chiral Recognition ◽  
Scale Up ◽  
Chiral Selector ◽  
Phase System ◽  
Optimal Conditions ◽  
Two Phase ◽  
Experimental Conditions ◽  
Aqueous Two Phase System ◽  
Recognition Ability

AbstractAn alcohol/salt-based aqueous two-phase system (ATPS) was employed for enantioseparation of (R,S)-mandelic acid (MA) and (R,S)-α-cyclohexylmandelic acid (α-CHMA). Sulfonated β-cyclodextrin (Sf-β-CD) with different degrees of substitution (DS) was considered as the chiral selector. The ethanol/(NH4)2SO4 system showed the optimal chiral recognition ability for MA. To optimize the experimental conditions, Sf-β-CD concentration, ethanol and salt concentration, temperature, and pH were studied. The recognition ability of enantiomers was mainly dependent on the type of the chiral selector but the ethanol and (NH4)2SO4 concentrations also had significant influence on the enantiomeric recognition. The maximum values of α and ee up of 1.69 and 16.3 % were obtained, respectively, for MA under the optimal conditions. A potential application of this alcohol/salt ATPS is the scale-up of chiral separation of MA.

l-Amino acid derived pyridinium-based chiral compounds and their efficacy in chiral recognition of lactate

RSC Advances ◽  
2015 ◽  
Vol 5 (31) ◽  
pp. 24499-24506 ◽  
Author(s):  
Kumaresh Ghosh ◽  
Anupam Majumdar
Keyword(s):  
Amino Acid ◽  
Chiral Recognition ◽  
Enantioselective Recognition ◽  
Chiral Compounds

A series ofl-amino acid derived pyridinium-based chiral compounds have been designed and synthesized. Among them, somel-valine derivatives show enantioselective recognition ofd-lactate in fluorescence.

Asymmetric Metal-Organic Frameworks with Double Helices for Enantioselective Recognition

CrystEngComm ◽  
2021 ◽  
Author(s):  
Yang Li ◽  
Shumei Chen ◽  
Zhong-Xuan Xu ◽  
Xin Wu ◽  
Huabin Zhang ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Chiral Recognition ◽  
Metal Organic Frameworks ◽  
Enantioselective Recognition ◽  
Double Helices ◽  
Recognition Ability ◽  
Metal Organic

A pair of homochiral metal-organic frameworks are elaborated by employing flexible enantiopure ligands. They possess interesting double helical chains and rich hydrogen-bonding environment, exhibiting excellent chiral recognition ability to carvone.

Enantioselective fluorescent sensors for chiral carboxylates based on BINOL — Synthesis and chiral recognition

2010 ◽  
Vol 88 (4) ◽  
pp. 367-374 ◽  
Author(s):  
Kuo-xi Xu ◽  
Yu-xia Wang ◽  
Shu-yan Jiao ◽  
Jin Zhao ◽  
Chao-jie Wang
Keyword(s):  
Nmr Spectroscopy ◽  
Chiral Recognition ◽  
Fluorescent Sensors ◽  
Enantioselective Recognition ◽  
H Nmr ◽  
Recognition Ability ◽  
Chiral Materials ◽  
Fluorescent Recognition ◽  
Derivatives Of ◽  
C Nmr

The four novel derivatives of 1,1′-bi-2-naphthol (BINOL) have been prepared, and the structures of these compounds have been characterized by IR, MS, 1H and 13C NMR spectroscopy, and elemental analysis. The enantioselective recognition of these receptors has been studied by fluorescence titration and 1H NMR spectroscopy. The receptors exhibited different chiral-recognition abilities towards some enantiomers of chiral materials and formed 1:1 complexes between host and guest. The receptors exhibit excellent enantioselective fluorescent-recognition ability towards the amino acid derivatives.

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