Creation of molecular complexities via a new Cu-catalyzed cascade reaction: a direct access to novel 2,2′-spirobiindole derivatives

2015 ◽  
Vol 51 (7) ◽  
pp. 1259-1262 ◽  
Author(s):  
Bagineni Prasad ◽  
Raju Adepu ◽  
Atul Kumar Sharma ◽  
Manojit Pal
Keyword(s):  
Cascade Reaction ◽  
Direct Access ◽  
Complex Molecules

A Cu-mediated cascade reaction of cyclopenta[b]indoles furnished an array of 2,2′-spirobi[indolin]-3-one based novel and complex molecules.

ChemInform Abstract: Creation of Molecular Complexities via a New Cu-Catalyzed Cascade Reaction: A Direct Access to Novel 2,2′-Spirobiindole Derivatives.

ChemInform ◽  
2015 ◽  
Vol 46 (24) ◽  
pp. no-no
Author(s):  
Bagineni Prasad ◽  
Raju Adepu ◽  
Atul Kumar Sharma ◽  
Manojit Pal
Keyword(s):  
Cascade Reaction ◽  
Direct Access

scholarly journals Organocatalytic Asymmetric Tandem/Domino Reactions Towards Access to Bioactive Products

2021 ◽  
Vol 25 ◽  
Author(s):  
Hélène Pellissier
Keyword(s):  
Total Synthesis ◽  
Asymmetric Catalysis ◽  
Biologically Active ◽  
Direct Access ◽  
Tandem Reactions ◽  
Domino Reactions ◽  
Complex Molecules ◽  
Total Syntheses ◽  
Key Steps ◽  
Simple Materials

: Tandem and domino reactions constitute economic routes to complex molecules starting from simple materials. Especially, combining these powerful procedures to asymmetric catalysis allow a direct access to many elaborated chiral products, including important key intermediates in total syntheses of important biologically active compounds. A range of various types of chiral organocatalysts have already been successfully applied to such syntheses. This review presents major developments in the total synthesis of bioactive products based on the use of enantioselective organocatalytic domino/tandem reactions as key steps. It is divided into three parts, dealing successively with syntheses based on organocatalytic asymmetric Michael-initiated domino reactions as key steps; aldol-initiated domino/tandem reactions and other domino reactions.

Quaternary Stereogenic Carbon Atoms in Complex Molecules by an Asymmetric, Organocatalytic, Triple-Cascade Reaction

2008 ◽  
Vol 14 (16) ◽  
pp. 4788-4791 ◽  
Author(s):  
Oriol Penon ◽  
Armando Carlone ◽  
Andrea Mazzanti ◽  
Manuela Locatelli ◽  
Letizia Sambri ◽  
...  
Keyword(s):  
Cascade Reaction ◽  
Complex Molecules

Pd-catalyzed isocyanide insertion/nucleophilic attack by indole C-3/desulfonylation in the same pot: a direct access to indoloquinolines of pharmacological interest

RSC Advances ◽  
2015 ◽  
Vol 5 (77) ◽  
pp. 62966-62970 ◽  
Author(s):  
Bagineni Prasad ◽  
Suresh Babu Nallapati ◽  
Sunder Kumar Kolli ◽  
Atul Kumar Sharma ◽  
Swapna Yellanki ◽  
...  
Keyword(s):  
Small Molecules ◽  
Cascade Reaction ◽  
Cytotoxic Agents ◽  
Direct Access ◽  
Nucleophilic Attack ◽  
Pharmacological Interest

A Pd-catalyzed new cascade reaction furnished indoloquinolin based small molecules as potential cytotoxic agents.

Alkaline Dissociation Products of Lumbricus Terrestris Hemoglobin Viewed with the STEM

1981 ◽  
Vol 39 ◽  
pp. 434-435
Author(s):  
O. H. Kapp ◽  
M. Ohtsuki ◽  
N. Robin ◽  
S. N. Vinogradov ◽  
A. V. Crewe
Keyword(s):  
Carbon Film ◽  
Lumbricus Terrestris ◽  
Uranyl Acetate ◽  
Acetate Solution ◽  
Oxygen Carriers ◽  
Complex Molecules ◽  
Thin Carbon ◽  
Thin Carbon Film ◽  
Multiple Copies ◽  
Hill Coefficients

Annelid extracellular hemoglobins are among the largest known proteins (M.W = 3.9 x 106), and together with the hemocyanins are the largest known oxygen carriers. They display oxygen affinities generally higher than those o vertebrate hemoglobins with Hill coefficients ranging from slightly higher than unity to values as high as 5-6. These complex molecules are composed of multiple copies of as many as six different polypeptides and posse: approximately 150 hemes per molecule.The samples were diluted to 100-200 μg/ml with distilled water just before application to a thin carbon film (∽15 Å thick). One percent (w/v) uranyl acetate solution was used for negative staining for 2 minutes and dried in air. The specimens were examined with the high resolution STEM. Their general appearance is that of a hexagonal bilayer (Fig. 1), each layer consisting of six spheroidal subunits. The corner to corner hexagonal dimensic is approximately 300 Å and the bilayer thickness approximately 200 Å.

Audiology Service Models in a Family Physician Practice Setting

2010 ◽  
Vol 6 (1) ◽  
pp. 24-32 ◽  
Author(s):  
Sridhar Krishnamurti
Keyword(s):  
Pediatric Patients ◽  
Practice Patterns ◽  
Healthcare Delivery ◽  
Direct Consequence ◽  
Direct Access ◽  
Practice Setting ◽  
Pediatric Populations ◽  
Family Practice Physicians ◽  
Primary Focus ◽  
Balance Problems

This article illustrates the potential of placing audiology services in a family physician’s practice setting to increase referrals of geriatric and pediatric patients to audiologists. The primary focus of family practice physicians is the diagnosis/intervention of critical systemic disorders (e.g., cardiovascular disease, diabetes, cancer). Hence concurrent hearing/balance disorders are likely to be overshadowed in such patients. If audiologists get referrals from these physicians and have direct access to diagnose and manage concurrent hearing/balance problems in these patients, successful audiology practice patterns will emerge, and there will be increased visibility and profitability of audiological services. As a direct consequence, audiological services will move into the mainstream of healthcare delivery, and the profession of audiology will move further towards its goals of early detection and intervention for hearing and balance problems in geriatric and pediatric populations.

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