A diarylethene as the SO2 gas generator upon UV irradiation

2015 ◽  
Vol 51 (9) ◽  
pp. 1736-1738 ◽  
Author(s):  
Ryuhei Kodama ◽  
Kimio Sumaru ◽  
Kana Morishita ◽  
Toshiyuki Kanamori ◽  
Kengo Hyodo ◽  
...  
Keyword(s):  
Cell Death ◽  
Uv Irradiation ◽  
Thermally Stable ◽  
Gas Generator ◽  
Induce Cell Death ◽  
Sulfone Group ◽  
Closed Ring ◽  
So2 Gas

A thermally stable closed-ring isomer of a diarylethene having a sulfone group works as the SO2 gas generator upon UV irradiation; photoisomerization followed by generation of SO2 gas to induce cell death.

Fluorous photosensitizers enhance photodynamic therapy with perfluorocarbon nanoemulsions

2017 ◽  
Author(s):  
Ellen Sletten ◽  
Rachael A. Day ◽  
Daniel A. Estabrook ◽  
Jessica K. Logan
Keyword(s):  
Cell Death ◽  
Photodynamic Therapy ◽  
Induce Cell Death ◽  
Perfluorocarbon Nanoemulsions

<p>Photodynamic therapy (PDT) requires photosensitizer, light, and oxygen to induce cell death. The majority of efforts to advance PDT focus only on the first two components. Here, we employ perfluorocarbon nanoemulsions to simultaneously deliver oxygen and photosensitizer. We find that the implementation of fluorous soluble photosensitizers enhances the efficacy of PDT. </p>

scholarly journals Transcriptional CDK inhibitors, CYC065 and THZ1 promote Bim-dependent apoptosis in primary and recurrent GBM through cell cycle arrest and Mcl-1 downregulation

2021 ◽  
Vol 12 (8) ◽  
Author(s):  
Viktorija Juric ◽  
Lance Hudson ◽  
Joanna Fay ◽  
Cathy E. Richards ◽  
Hanne Jahns ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Death ◽  
Cell Cycle Arrest ◽  
Cortical Neurons ◽  
Apoptotic Cell ◽  
Cdk Inhibitors ◽  
Induce Cell Death ◽  
Viability Loss ◽  
Cycle Arrest ◽  
Recurrent Gbm

AbstractActivation of cyclin-dependent kinases (CDKs) contributes to the uncontrolled proliferation of tumour cells. Genomic alterations that lead to the constitutive activation or overexpression of CDKs can support tumourigenesis including glioblastoma (GBM), the most common and aggressive primary brain tumour in adults. The incurability of GBM highlights the need to discover novel and more effective treatment options. Since CDKs 2, 7 and 9 were found to be overexpressed in GBM, we tested the therapeutic efficacy of two CDK inhibitors (CKIs) (CYC065 and THZ1) in a heterogeneous panel of GBM patient-derived cell lines (PDCLs) cultured as gliomaspheres, as preclinically relevant models. CYC065 and THZ1 treatments suppressed invasion and induced viability loss in the majority of gliomaspheres, irrespective of the mutational background of the GBM cases, but spared primary cortical neurons. Viability loss arose from G2/M cell cycle arrest following treatment and subsequent induction of apoptotic cell death. Treatment efficacies and treatment durations required to induce cell death were associated with proliferation velocities, and apoptosis induction correlated with complete abolishment of Mcl-1 expression, a cell cycle-regulated antiapoptotic Bcl-2 family member. GBM models generally appeared highly dependent on Mcl-1 expression for cell survival, as demonstrated by pharmacological Mcl-1 inhibition or depletion of Mcl-1 expression. Further analyses identified CKI-induced Mcl-1 loss as a prerequisite to establish conditions at which the BH3-only protein Bim can efficiently induce apoptosis, with cellular Bim amounts strongly correlating with treatment efficacy. CKIs reduced proliferation and promoted apoptosis also in chick embryo xenograft models of primary and recurrent GBM. Collectively, these studies highlight the potential of these novel CKIs to suppress growth and induce cell death of patient-derived GBM cultures in vitro and in vivo, warranting further clinical investigation.

New Multi-Walled Carbon Nanotube of industrial interest induce cell death in murine fibroblast cells

2021 ◽  
pp. 1-31
Author(s):  
Krissia Franco de Godoy ◽  
Joice Margareth de Almeida Rodolpho ◽  
Patrícia Brassolatti ◽  
Bruna Dias de Lima Fragelli ◽  
Cynthia Aparecida de Castro ◽  
...  
Keyword(s):  
Cell Death ◽  
Carbon Nanotube ◽  
Fibroblast Cells ◽  
Induce Cell Death ◽  
Multi Walled Carbon Nanotube ◽  
Murine Fibroblast

scholarly journals VIP-derived sequences modified by N-terminal stearyl moiety induce cell death: the human keratinocyte as a model

FEBS Letters ◽  
2000 ◽  
Vol 475 (2) ◽  
pp. 71-77 ◽  
Author(s):  
Ruth Granoth ◽  
Mati Fridkin ◽  
Sara Rubinraut ◽  
Illana Gozes
Keyword(s):  
Cell Death ◽  
Induce Cell Death ◽  
Human Keratinocyte

scholarly journals Calcium Phosphate Crystals Induce Cell Death in Human Vascular Smooth Muscle Cells

2008 ◽  
Vol 103 (5) ◽  
Author(s):  
Alexandra E. Ewence ◽  
Martin Bootman ◽  
H. Llewelyn Roderick ◽  
Jeremy N. Skepper ◽  
Geraldine McCarthy ◽  
...  
Keyword(s):  
Cell Death ◽  
Smooth Muscle ◽  
Calcium Phosphate ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Induce Cell Death

B cells from patients with multiple sclerosis induce cell death via apoptosis in neurons in vitro

2017 ◽  
Vol 309 ◽  
pp. 88-99 ◽  
Author(s):  
Robert P. Lisak ◽  
Liljana Nedelkoska ◽  
Joyce A. Benjamins ◽  
Dana Schalk ◽  
Beverly Bealmear ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cell Death ◽  
B Cells ◽  
Induce Cell Death
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