scholarly journals Chemical biology of genomic DNA: minimizing PCR bias

2014 ◽  
Vol 50 (81) ◽  
pp. 12047-12049 ◽  
Author(s):  
Gordon R. McInroy ◽  
Eun-Ang Raiber ◽  
Shankar Balasubramanian
Keyword(s):  
Chemical Modification ◽  
Genomic Dna ◽  
Chemical Biology ◽  
Synthesis And Characterization ◽  
Design Synthesis ◽  
Pcr Bias

We describe a PCR bias induced by chemical modification of DNA, and exemplify a solution with the design, synthesis and characterization of a cleavable probe designed to leave minimal chemical scarring.

scholarly journals Design of an n-type low glass transition temperature radical polymer

2021 ◽  
Author(s):  
Teng Chi ◽  
Siddhartha Akkiraju ◽  
Zihao Liang ◽  
Ying Tan ◽  
Ho Joong Kim ◽  
...  
Keyword(s):  
Glass Transition ◽  
Transition Temperature ◽  
Glass Transition Temperature ◽  
Synthesis And Characterization ◽  
Design Synthesis

We document the design, synthesis, and characterization of the first low glass transition temperature, n-type (i.e., preferentially-reduced) radical polymer.

Design, Synthesis, and Characterization of Novel CXCR4 Antagonists Featuring Cyclic Amines

ChemMedChem ◽  
2020 ◽  
Vol 15 (13) ◽  
pp. 1150-1162
Author(s):  
Yu Lin ◽  
Zhanhui Li ◽  
Haikuo Ma ◽  
Yujie Wang ◽  
Xu Wang ◽  
...  
Keyword(s):  
Synthesis And Characterization ◽  
Design Synthesis ◽  
Cyclic Amines ◽  
Cxcr4 Antagonists

HYDRAmers: design, synthesis and characterization of different generation novel Hydra-like dendrons based on multifunctionalized adamantane

2011 ◽  
Vol 47 (31) ◽  
pp. 8955 ◽  
Author(s):  
Giuseppe Lamanna ◽  
Julie Russier ◽  
Cécilia Ménard-Moyon ◽  
Alberto Bianco
Keyword(s):  
Synthesis And Characterization ◽  
Design Synthesis

scholarly journals Design, synthesis and characterization of peptidomimetic conjugate of BODIPY targeting HER2 protein extracellular domain

2013 ◽  
Vol 65 ◽  
pp. 60-69 ◽  
Author(s):  
Sashikanth Banappagari ◽  
Alecia McCall ◽  
Krystal Fontenot ◽  
M. Graca H. Vicente ◽  
Amit Gujar ◽  
...  
Keyword(s):  
Extracellular Domain ◽  
Synthesis And Characterization ◽  
Design Synthesis ◽  
Her2 Protein

DESIGN, SYNTHESIS, AND CHARACTERIZATION OF THE SOME NOVEL 2‐AMINO-PYRIDINE‐3‐ CARBONITRILE AND 2‐AMINO-4H-PYRAN‐3‐CARBONITRILE DERIVATIVES AGAINST ANTIMICROBIAL ACTIVITY AND ANTIOXIDANT ACTIVITY

2020 ◽  
pp. 125-134
Author(s):  
SURENDRA BABU LAGU ◽  
RAJENDRA PRASAD YEJELLA
Keyword(s):  
Antimicrobial Activity ◽  
Antioxidant Activity ◽  
Antimicrobial Activities ◽  
Docking Studies ◽  
Synthesis And Characterization ◽  
Zone Of Inhibition ◽  
Design Synthesis ◽  
Instrumental Methods ◽  
Objective Investigation

Objective: Investigation, the series of newer 2‐amino-pyridine‐3‐carbonitrile and 2‐amino-4H-pyran‐3‐carbonitrile derivative were synthesized and evaluated antimicrobial activities and antioxidant activity. Methods: Novel synthesized chalcones were further condensation to give 2-amino-3-cyanopyridine and 2-amino-3-cyanopyrans in the presence of malononitrile, pyridine, and ammonia acetate. The product is characterized by conventional and instrumental methods. Pyridine and 4-H-Pyran and their analogs occupy prime position due to their diverse applications. Results: The compounds A3C and B3C exhibited marked zone of inhibition with 30.02±0.02 mm and 29.06±0.01 mm, respectively. Docking studies suggested possible interactions with dihydrofolic reductase 4 with 9.15 and −9.67 kcal/mol, respectively. The IC50 30.28±0.01 exhibited A3C by 2,2-diphenylpicrylhydrazyl methods which is better among the series. The 2-amino-3-cyanopyridine derivatives were found good activity than 2-amino-3-cyanopyrane derivative. Among all synthesized compounds few having potent activity and some are near to the standard. Conclusion: Antimicrobial activity and antioxidant of the newly synthesized pyrans and pyridines derivatives will definitely inspire future researchers for the preparation of new analogs.

scholarly journals Design, Synthesis, and Characterization of a Fluorescence Polarization Pan-BET Bromodomain Probe

2018 ◽  
Vol 9 (12) ◽  
pp. 1223-1229 ◽  
Author(s):  
Carolyn N. Paulson ◽  
Xianghong Guan ◽  
Alex M. Ayoub ◽  
Alice Chan ◽  
Rezaul M. Karim ◽  
...  
Keyword(s):  
Fluorescence Polarization ◽  
Synthesis And Characterization ◽  
Design Synthesis

Design, Synthesis, and Characterization of a −Donor−Bridge−Acceptor−Bridge- Type Block Copolymer via Alkoxy- and Sulfone- Derivatized Poly(phenylenevinylenes)

2006 ◽  
Vol 39 (13) ◽  
pp. 4317-4326 ◽  
Author(s):  
Cheng Zhang ◽  
Soobum Choi ◽  
James Haliburton ◽  
Taina Cleveland ◽  
Rui Li ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Synthesis And Characterization ◽  
Design Synthesis ◽  
Bridge Type
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