An efficient one-pot strategy for the highly regioselective metal-free synthesis of 1,4-disubstituted-1,2,3-triazoles

2014 ◽  
Vol 50 (80) ◽  
pp. 11926-11929 ◽  
Author(s):  
Akbar Ali ◽  
Arlene G. Corrêa ◽  
Diego Alves ◽  
Julio Zukerman-Schpector ◽  
Bernhard Westermann ◽  
...  
Keyword(s):  
Regioselective Synthesis ◽  
Dipolar Cycloaddition ◽  
One Pot ◽  
Inverse Electron Demand ◽  
Metal Free ◽  
Electron Demand

A simple and efficient metal-free methodology for the regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles by applying a novel inverse electron-demand-1,3-dipolar cycloaddition approach has been developed.

Tandem inverse electron demand Diels–Alder, retro-Diels–Alder and intramolecular Diels–Alder sequences: one-pot synthesis of diaza-polycycles

Tetrahedron ◽  
2007 ◽  
Vol 63 (26) ◽  
pp. 6004-6014 ◽  
Author(s):  
William J. Bromley ◽  
Mairi Gibson ◽  
Stuart Lang ◽  
Steven A. Raw ◽  
Adrian C. Whitwood ◽  
...  
Keyword(s):  
Diels Alder ◽  
One Pot ◽  
Inverse Electron Demand ◽  
One Pot Synthesis ◽  
Electron Demand

ChemInform Abstract: Inverse Electron-Demand 1,3-Dipolar Cycloaddition of Nitrile Oxide with Common Nitriles Leading to 3-Functionalized 1,2,4-Oxadiazoles.

ChemInform ◽  
2012 ◽  
Vol 43 (8) ◽  
pp. no-no
Author(s):  
Nagatoshi Nishiwaki ◽  
Kazuya Kobiro ◽  
Shotaro Hirao ◽  
Jun Sawayama ◽  
Kazuhiko Saigo ◽  
...  
Keyword(s):  
Nitrile Oxide ◽  
Dipolar Cycloaddition ◽  
Inverse Electron Demand ◽  
Electron Demand

ChemInform Abstract: Inverse Electron-Demand 1,3-Dipolar Cycloaddition Reactions of Cyclooctyne with Pyridinium Bis(methoxycarbonyl)methylides.

ChemInform ◽  
2010 ◽  
Vol 32 (36) ◽  
pp. no-no
Author(s):  
Kiyoshi Matsumoto ◽  
Naoto Hayashi ◽  
Yukio Ikemi ◽  
Mitsuo Toda ◽  
Takane Uchida ◽  
...  
Keyword(s):  
Dipolar Cycloaddition ◽  
Cycloaddition Reactions ◽  
Inverse Electron Demand ◽  
Electron Demand

The Coupling-Isomerization Approach to Enimines and the First Sequential Three-Component Access to 2-Ethoxy Pyridines

2004 ◽  
Vol 59 (4) ◽  
pp. 443-450 ◽  
Author(s):  
Oana G. Dediu ◽  
Nasser A. M. Yehia ◽  
Thomas J. J. Müller
Keyword(s):  
Diels Alder ◽  
Isomerization Reaction ◽  
One Pot ◽  
Inverse Electron Demand ◽  
Ketene Acetal ◽  
Electron Demand

AbstractThe coupling-isomerization reaction (CIR) of electron-deficient halides 1 with N-[1-(hetero)arylprop-2-ynyl] tosyl amides 2 leads to the formation of N-tosyl enimines 3, in good to excellent yields. These electron deficient heterodienes are perfectly suited for Diels-Alder reactions with inverse electron demand. In the sense of a one-pot reaction a three-component CIR-cyclocondensation sequence of 1, 2a, and diethyl ketene acetal gives rise to the formation of 2-ethoxy 6-(p-anisyl)pyridines 4 in moderate to good yields.

A transition metal-free approach towards the regioselective synthesis of β-carboline tethered pyrroles and 2,3-dihydro-1H-pyrroles

2020 ◽  
Vol 44 (28) ◽  
pp. 12370-12383
Author(s):  
Manpreet Singh ◽  
Avijit Kumar Paul ◽  
Virender Singh
Keyword(s):  
Transition Metal ◽  
Regioselective Synthesis ◽  
One Pot ◽  
Sequential Approach ◽  
Metal Free

A transition metal-free one-pot sequential approach has been unfolded for the synthesis of β-carboline tethered pyrroles and 2,3-dihydro-1H-pyrroles by using highly diverse 1-formyl-9H-β-carbolines as a template.

endo-Selective Asymmetric Inverse Electron-Demand 1,3-Dipolar Cycloaddition Reaction of Nitrones.

ChemInform ◽  
2007 ◽  
Vol 38 (2) ◽  
Author(s):  
Tomoko Ashizawa ◽  
Natsuki Ohtsuki ◽  
Tomoyuki Miura ◽  
Makoto Ohya ◽  
Takaomi Shinozaki ◽  
...  
Keyword(s):  
Cycloaddition Reaction ◽  
Dipolar Cycloaddition ◽  
Inverse Electron Demand ◽  
Electron Demand

scholarly journals Inverse electron-demand 1,3-dipolar cycloaddition of nitrile oxide with common nitriles leading to 3-functionalized 1,2,4-oxadiazoles

2011 ◽  
Vol 9 (19) ◽  
pp. 6750 ◽  
Author(s):  
Nagatoshi Nishiwaki ◽  
Kazuya Kobiro ◽  
Shotaro Hirao ◽  
Jun Sawayama ◽  
Kazuhiko Saigo ◽  
...  
Keyword(s):  
Nitrile Oxide ◽  
Dipolar Cycloaddition ◽  
Inverse Electron Demand ◽  
Electron Demand
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