Direct oxidative nitration of aromatic sulfonamides under mild conditions

2014 ◽  
Vol 50 (69) ◽  
pp. 9936-9938 ◽  
Author(s):  
Ying-Xiu Li ◽  
Lian-Hua Li ◽  
Yan-Fang Yang ◽  
Hui-Liang Hua ◽  
Xiao-Biao Yan ◽  
...  
Keyword(s):  
Low Cost ◽  
Mild Conditions ◽  
Reaction Proceeds ◽  
Scale Preparation ◽  
Oxidative Nitration

This efficient reaction proceeds under very mild conditions with low cost nitration reagents and can be applied in gram-scale preparation.

scholarly journals Nickel-Catalyzed Asymmetric Reductive Cross-Coupling of α-Chloroesters with (Hetero)Aryl Iodides

2021 ◽  
Author(s):  
Travis DeLano ◽  
Sara Dibrell ◽  
Caitlin R. Lacker ◽  
Adam Pancoast ◽  
Kelsey Poremba ◽  
...  
Keyword(s):  
Cross Coupling ◽  
Mild Conditions ◽  
Aryl Iodides ◽  
Reaction Proceeds

An asymmetric reductive cross-coupling of α-chloroesters and (hetero)aryl iodides is reported. This nickel-catalyzed reaction proceeds with a chiral BiOX ligand under mild conditions, affording α-arylesters in good yields and enantioselectivities....

scholarly journals Photocatalytic three-component asymmetric sulfonylation via direct C(sp3)-H functionalization

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Shi Cao ◽  
Wei Hong ◽  
Ziqi Ye ◽  
Lei Gong
Keyword(s):  
Asymmetric Catalysis ◽  
Organic Synthesis ◽  
Photochemical Reaction ◽  
Low Cost ◽  
Bioactive Molecules ◽  
Atom Economy ◽  
Mild Conditions ◽  
Wide Range ◽  
Unsaturated Carbonyl Compound ◽  
Direct Functionalization

AbstractThe direct and selective C(sp3)-H functionalization of cycloalkanes and alkanes is a highly useful process in organic synthesis owing to the low-cost starting materials, the high step and atom economy. Its application to asymmetric catalysis, however, has been scarcely explored. Herein, we disclose our effort toward this goal by incorporation of dual asymmetric photocatalysis by a chiral nickel catalyst and a commercially available organophotocatalyst with a radical relay strategy through sulfur dioxide insertion. Such design leads to the development of three-component asymmetric sulfonylation involving direct functionalization of cycloalkanes, alkanes, toluene derivatives or ethers. The photochemical reaction of a C(sp3)-H precursor, a SO2 surrogate and a common α,β-unsaturated carbonyl compound proceeds smoothly under mild conditions, delivering a wide range of biologically interesting α-C chiral sulfones with high regio- and enantioselectivity (>50 examples, up to >50:1 rr and 95% ee). This method is applicable to late-stage functionalization of bioactive molecules, and provides an appealing access to enantioenriched compounds starting from the abundant hydrocarbon compounds.

A metal-free radical cascade reaction of phosphine oxides with 2-aryloxy phenylacetylenes to assemble diphosphonyl xanthene derivatives

2021 ◽  
Author(s):  
Tao Fan ◽  
Yan Liu ◽  
Caina Jiang ◽  
Yanli Xu ◽  
Yan-Yan Chen
Keyword(s):  
Free Radical ◽  
Transition Metal ◽  
Cascade Reaction ◽  
Phosphine Oxides ◽  
Metal Free ◽  
Mild Conditions ◽  
Xanthene Derivatives ◽  
Reaction Proceeds ◽  
Radical Cascade

A radical cascade reaction of 2-aryloxy phenylacetylene with phosphine oxides promoted by K2S2O8 was developed, provided diphosphonyl xanthenes as products. This reaction proceeds under transition metal-free and mild conditions with...

Environment-Friendly Design of Lithium Batteries Starting from Biopolymer-Based Electrolyte

NANO ◽  
2021 ◽  
pp. 2130006
Author(s):  
Jiayuan Shi ◽  
Bin Shi
Keyword(s):  
Lithium Batteries ◽  
Lithium Battery ◽  
Water Solubility ◽  
Low Cost ◽  
Organic Liquid ◽  
Adhesive Property ◽  
Environment Friendly ◽  
Battery Materials ◽  
Mild Conditions ◽  
Film Forming

The nondegradable nature and toxicity of organic liquid electrolytes reveal the design deficiency of lithium batteries in environmental protection. Biopolymers can be extracted from biomass under mild conditions, thus they are usually low cost and renewable. The unique characteristics of biopolymers such as water solubility, film-forming capability and adhesive property are of importance for lithium battery. The studies on the biopolymer materials for lithium batteries have been reviewed in this work. Although a lot of work on the biopolymer-based battery materials has been reported, it is still a challenge in the design of lithium battery with zero pollution and zero waste.

Bromotrifluoromethane: A Useful Reagent for Hydrotrifluoromethylation of Alkenes and Alkynes

Synlett ◽  
2018 ◽  
Vol 29 (08) ◽  
pp. 1028-1032 ◽  
Author(s):  
Xing Zheng ◽  
Xingang Zhang ◽  
Yu-Yan Ren
Keyword(s):  
Visible Light ◽  
Organic Synthesis ◽  
Functional Group ◽  
Mild Conditions ◽  
Industrial Material ◽  
Reaction Proceeds

Bromotrifluoromethane (CF3Br) is a simple, inexpensive and abundant industrial material employed as a trifluoromethylating reagent. However, only limited strategies using CF3Br as a fluorine source are reported. Herein, we describe a visible-light-induced hydrotrifluoromethylation of alkenes and alkynes with CF3Br. The reaction proceeds under mild conditions with good functional group tolerance, providing a new route for the application of BrCF3 in organic synthesis.

scholarly journals Enantioenriched Quaternary α-Pentafluoroethyl Derivatives of Alkyl 1-Indanone-2-Carboxylates

2020 ◽  
Author(s):  
Albert Granados ◽  
Anna Balleteros ◽  
Adelina Vallribera
Keyword(s):  
Hypervalent Iodine ◽  
Catalytic Method ◽  
Quaternary Centers ◽  
Mild Conditions ◽  
Reaction Proceeds ◽  
Mechanistic Investigations ◽  
Derivatives Of

An electrophilic enantioselective catalytic method for the a-pentafluoroethylation of alkyl 1-indanone-2-carboxylates is described. Under the use of La(OTf)<sub>3</sub> in combination with (<i>S,R</i>)-indanyl-<i>pybox</i> ligand good results in terms of yield and enantioselectivities were achieved (up to 89% <i>ee</i>). The reaction proceeds under mild conditions leading to the formation of enantioenriched quaternary centers. This methodology uses an hypervalent iodine(III)-CF<sub>2</sub>CF<sub>3</sub> reagent and mechanistic investigations are consistent with the involvement of a radical pathway.

scholarly journals Non-metal boron atoms on CuB12 monolayer as efficient catalytic sites for urea production

2022 ◽  
Author(s):  
Changyan Zhu ◽  
Chaoxia Wen ◽  
Miao Wang ◽  
Min Zhang ◽  
Yun Geng ◽  
...  
Keyword(s):  
Low Cost ◽  
Coupling Reaction ◽  
Promising Alternative ◽  
Mild Conditions ◽  
Catalytic Sites ◽  
Urea Production

Electrocatalytic C-N coupling reaction to convert CO2 and N2 into urea under mild conditions has been proposed to be a promising alternative experimentally, but the development of high-stable, low-cost and...

Gram-scale Preparation of Acyl Fluorides and Their Reactions with Hindered Nucleophiles

Synthesis ◽  
2021 ◽  
Author(s):  
Michał Tryniszewski ◽  
Michal Barbasiewicz
Keyword(s):  
Phase Transfer ◽  
Lithium Amide ◽  
Acyl Chlorides ◽  
Mild Conditions ◽  
Convenient Procedure ◽  
Halogen Exchange ◽  
Scale Preparation ◽  
Biphasic Mixture ◽  
Sterically Hindered

A series of acyl fluorides was synthesized at 100 mmol scale using phase transfer catalyzed halogen exchange between acyl chlorides and aqueous bifluoride solution. The convenient procedure consists of vigorous stirring of the biphasic mixture at rt, followed by extraction and distillation. Isolated acyl fluorides (usually 7 g to 20 g) display excellent purity, and can be transformed into sterically hindered amides and esters, when treated with lithium amide bases and alkoxides under mild conditions.

Nickel-Catalyzed Reductive Monofluoroakylation of Alkyl Tosylate with Bromofluoromethane to Access Primary Alkyl Fluoride

2021 ◽  
Author(s):  
Ru Cui ◽  
Jie Sheng ◽  
Bing-Bing Wu ◽  
Duo-Duo Hu ◽  
Hong-Qian Zheng ◽  
...  
Keyword(s):  
Functional Group ◽  
High Efficiency ◽  
Low Cost ◽  
Raw Material ◽  
Mild Conditions

A nickel-catalysed direct terminal monofluormethlyation between alkyl tosylates and a low-cost, industrial raw material bromofluoromethane has been developed. This transformation has demonstrated high efficiency, mild conditions, and good functional-group compatibility....

Synthesis of Isoquinoline-1,3(2H,4H)-diones by Visible-light-mediated the Cyclization of Acryloylbenzamides with Alkyl Boronic Acids, Arylsulfonylhydrazides and Oxime Esters

Synthesis ◽  
2022 ◽  
Author(s):  
Jiahui Fu ◽  
Xingxing Cai ◽  
Yihuo Liu ◽  
Jing-Hua Li ◽  
Dongping Cheng ◽  
...  
Keyword(s):  
Visible Light ◽  
Bioactive Compounds ◽  
Boronic Acids ◽  
Radical Addition ◽  
Tandem Reaction ◽  
Good Opportunity ◽  
Mild Conditions ◽  
Reaction Proceeds

An efficient visible-light-mediated tandem reaction of acryloylbenzamides with alkyl boronic acids, arylsulfonylhydrazides and oxime esters is developed. The reaction proceeds the radical addition and cyclization to give various isoquinoline-1,3(2H,4H)-diones in satisfactory yields under mild conditions, which provides a good opportunity to discover new meaningful bioactive compounds.

Sign in / Sign up

Export Citation Format

Share Document