Aerobic copper-catalyzed oxidative [6C+1C] annulation: an efficient route to seven-membered carbocycles

2014 ◽  
Vol 50 (63) ◽  
pp. 8764-8767 ◽  
Author(s):  
Xiao Liu ◽  
Lingjuan Zhang ◽  
Xianxiu Xu ◽  
Shan Wang ◽  
Ling Pan ◽  
...  
Keyword(s):  
Michael Addition ◽  
Oxidation Reaction ◽  
Ethyl Cyanoacetate ◽  
Radical Cyclization ◽  
Diastereoselective Synthesis ◽  
Ketene Dithioacetals ◽  
Efficient Route

A copper-catalyzed aerobic tandem Michael addition–intramolecular radical cyclization–benzyl C(sp3)–H bond oxidation reaction of dicinnamoyl ketene dithioacetals and ethyl cyanoacetate was developed for the diastereoselective synthesis of seven-membered carbocycles.

Uncatalyzed diastereoselective synthesis of alkyliminofurochromone-derived benzylmalononitriles via a three-component cascade reaction: competition between Diels–Alder cycloaddition and Michael addition

2021 ◽  
Author(s):  
Mohammad Bagher Teimouri ◽  
Zahra Mokhtare ◽  
Hamid Reza Khavasi
Keyword(s):  
Michael Addition ◽  
Heterocyclic Ring ◽  
Cascade Reaction ◽  
Diels Alder ◽  
Chemical Bonds ◽  
Diastereoselective Synthesis ◽  
Atom Economy ◽  
One Pot

Three new chemical bonds and three stereogenic centres and one heterocyclic ring were assembled stereoselectively in a convenient high atom-economy one-pot operation.

Diastereoselective synthesis of bicyclo[2.2.2]octanes by double Michael addition

1989 ◽  
Vol 30 (5) ◽  
pp. 547-550 ◽  
Author(s):  
Dietrich Spitzner ◽  
Peter Wagner ◽  
Arndt Simon ◽  
Karl Peters
Keyword(s):  
Michael Addition ◽  
Diastereoselective Synthesis

Diastereoselective Synthesis of Vicinal Diamines by Aza-Michael Addition of Chiral Phenethylamine to Nitroalkenes

2018 ◽  
Vol 3 (34) ◽  
pp. 9916-9919
Author(s):  
Chunying Ma ◽  
Jianxun Du ◽  
Yuhua Liang ◽  
Wenhua Feng
Keyword(s):  
Michael Addition ◽  
Diastereoselective Synthesis ◽  
Vicinal Diamines

Selective synthesis of acylated caprolactam via sequential Michael addition/palladium-catalyzed alpha-arylation of ketones

2021 ◽  
Author(s):  
Xin-Xing Wu ◽  
Hao Ye ◽  
Ming Li ◽  
Jianing Qian ◽  
Hong Dai ◽  
...  
Keyword(s):  
Michael Addition ◽  
Bond Formation ◽  
Selective Synthesis ◽  
Methyl Ketones ◽  
Rapid Access ◽  
Palladium Catalyzed ◽  
Efficient Route

A formal [6 + 1] annulation reaction provides an efficient route enabling rapid access to diverse caprolactams by the double C–C bond formation of the same site from methyl ketones.

Highly Functionalized Cyclopentane Derivatives by Tandem Michael Addition/Radical Cyclization/Oxygenation Reactions

2015 ◽  
Vol 21 (27) ◽  
pp. 9877-9888 ◽  
Author(s):  
Martin Holan ◽  
Radek Pohl ◽  
Ivana Císařová ◽  
Blanka Klepetářová ◽  
Peter G. Jones ◽  
...  
Keyword(s):  
Michael Addition ◽  
Radical Cyclization

Diastereoselective synthesis of pitavastatin calcium via bismuth-catalyzed two-component hemiacetal/oxa-Michael addition reaction

2015 ◽  
Vol 13 (38) ◽  
pp. 9813-9819 ◽  
Author(s):  
Fangjun Xiong ◽  
Haifeng Wang ◽  
Lingjie Yan ◽  
Lingjun Xu ◽  
Yuan Tao ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Michael Addition ◽  
Addition Reaction ◽  
Diastereoselective Synthesis ◽  
Michael Addition Reaction ◽  
Two Component ◽  
Pitavastatin Calcium

An efficient and concise asymmetric synthesis of pitavastatin calcium (1) starting from commercially available (S)-epichlorohydrin is described.

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