Enantioselective synthesis of benzazepinoindoles bearing trifluoromethylated quaternary stereocenters catalyzed by chiral spirocyclic phosphoric acids

2014 ◽  
Vol 50 (56) ◽  
pp. 7538-7541 ◽  
Author(s):  
Xuejian Li ◽  
Di Chen ◽  
Haorui Gu ◽  
Xufeng Lin
Keyword(s):  
Enantioselective Synthesis ◽  
Trifluoromethyl Ketones ◽  
Quaternary Stereocenters ◽  
Phosphoric Acids

SPA-catalyzed iso-Pictet–Spengler reaction of C-2-linked o-aminobenzylindoles and trifluoromethyl ketones for construction of optically enriched benzazepinoindole derivatives has been realised.

scholarly journals Enantioselective synthesis of α-alkenyl α-amino acids via N–H insertion reactions

2016 ◽  
Vol 7 (2) ◽  
pp. 1104-1108 ◽  
Author(s):  
Jun-Xia Guo ◽  
Ting Zhou ◽  
Bin Xu ◽  
Shou-Fei Zhu ◽  
Qi-Lin Zhou
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Enantioselective Synthesis ◽  
Insertion Reaction ◽  
Amino Acid Derivatives ◽  
Insertion Reactions ◽  
Phosphoric Acids

A new highly enantioselective route to α-alkenyl α-amino acid derivatives using a N–H insertion reaction of vinyldiazoacetates and tert-butyl carbamate cooperatively catalyzed by achiral dirhodium(ii) carboxylates and chiral spiro phosphoric acids was developed.

Enantioselective Synthesis of Dihydropyridines Containing Quaternary Stereocenters Through Dearomatization of Pyridinium Salts

ACS Catalysis ◽  
2019 ◽  
Vol 10 (1) ◽  
pp. 51-55 ◽  
Author(s):  
Donovan J. Robinson ◽  
Sean P. Spurlin ◽  
John D. Gorden ◽  
Rashad R. Karimov
Keyword(s):  
Enantioselective Synthesis ◽  
Pyridinium Salts ◽  
Quaternary Stereocenters

Palladium(ii)-catalyzed asymmetric C–H carbonylation to diverse isoquinoline derivatives bearing all-carbon quaternary stereocenters

2020 ◽  
Vol 56 (78) ◽  
pp. 11605-11608
Author(s):  
Yan Li ◽  
Xiu-Fen Cheng ◽  
Fan Fei ◽  
Tian-Rui Wu ◽  
Kang-Jie Bian ◽  
...  
Keyword(s):  
Late Stage ◽  
Enantioselective Synthesis ◽  
One Step ◽  
Quaternary Stereocenters ◽  
Quaternary Stereocenter ◽  
Isoquinoline Derivatives

Enantioselective synthesis of isoquinoline derivatives bearing an all-carbon quaternary stereocenter in one step via asymmetric Pd(ii)-catalyzed C–H activation and multiple late-stage derivatizations.

The enantioselective construction of trifluoromethylated quaternary stereocenters via the Rh-catalyzed asymmetric dehydrated arylation of unprotected hemiaminals

2020 ◽  
Vol 7 (2) ◽  
pp. 340-344 ◽  
Author(s):  
Yu-Tuo Sun ◽  
Dong-Xing Zhu ◽  
Xiaofeng Rao ◽  
Ming-Hua Xu
Keyword(s):  
Catalyst System ◽  
Enantioselective Synthesis ◽  
Quaternary Carbon ◽  
Quaternary Stereocenters

An effective Rh/chiral diene catalyst system for the highly enantioselective synthesis of chiral benzosultams bearing trifluoromethylated quaternary carbon stereocenters has been developed.

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