Visible light induced fast synthesis of protein–polymer conjugates: controllable polymerization and protein activity

2014 ◽  
Vol 50 (49) ◽  
pp. 6506-6508 ◽  
Author(s):  
Xin Li ◽  
Lei Wang ◽  
Gaojian Chen ◽  
David M. Haddleton ◽  
Hong Chen
Keyword(s):  
Visible Light ◽  
Ambient Temperature ◽  
Raft Polymerization ◽  
Protein Activity ◽  
Polymer Conjugates ◽  
Protein Polymer ◽  
Novel Method ◽  
Fast Synthesis

Visible light induced fast and controllable RAFT polymerization from protein as a novel method for preparing protein–polymer conjugates at ambient temperature.

Transiently responsive protein–polymer conjugates via a ‘grafting-from’ RAFT approach for intracellular co-delivery of proteins and immune-modulators

2015 ◽  
Vol 51 (73) ◽  
pp. 13972-13975 ◽  
Author(s):  
N. Vanparijs ◽  
R. De Coen ◽  
D. Laplace ◽  
B. Louage ◽  
S. Maji ◽  
...  
Keyword(s):  
Raft Polymerization ◽  
Immune Modulators ◽  
Polymer Conjugates ◽  
Protein Polymer ◽  
Grafting From ◽  
Response To Temperature

‘Grafting-from’ RAFT polymerization is used to synthesize protein–polymer conjugates that change from the soluble to the aggregated state in response to temperature, but become fully soluble by acid triggered hydrolysis.

Protein–polymer conjugates prepared via host–guest interactions: effects of the conjugation site, polymer type and molecular weight on protein activity

2016 ◽  
Vol 7 (32) ◽  
pp. 5139-5146 ◽  
Author(s):  
Limin Cao ◽  
Xiujuan Shi ◽  
Yuecheng Cui ◽  
Weikang Yang ◽  
Gaojian Chen ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Protein Activity ◽  
Polymer Conjugates ◽  
Protein Polymer ◽  
P Protein ◽  
Polymer Type

Protein–polymer conjugates are prepared via host–guest interactions and the effects of various parameters on protein activity are investigated.

Boron-Doped TiO2 (B-TiO2): Visible-Light Photocatalytic Di-functionalization of Alkenes and Alkynes

2021 ◽  
Author(s):  
Mona Hosseini-Sarvari ◽  
Atefe Valikhani
Keyword(s):  
Visible Light ◽  
Doped Tio2 ◽  
Boron Doped ◽  
Novel Method ◽  
Visible Light Photocatalytic

Boron doped TiO2 (B-TiO2) was prepared, characterized, and successfully applied as a reusable, inexpensive, available, and heterogeneous nano photocatalyst under visible light for a novel method of construction of phenacyl...

Photosensitizer-Free Synthesis of β-Keto Sulfones via Visible-Light-Induced Oxysulfonylation of Alkenes with Sulfonic Acids

2021 ◽  
Author(s):  
Zhen Peng ◽  
Yun-Yun Hong ◽  
Sha Peng ◽  
Xiang-Qin Xu ◽  
Shan-Shan Tang ◽  
...  
Keyword(s):  
Visible Light ◽  
Ambient Temperature ◽  
Sulfonic Acids ◽  
Environment Friendly

An practical and environment-friendly methodology for the construction of β-ketosulfones through visible-light induced direct oxysulfonylation of alkenes with sulfonic acids at ambient temperature under open-air conditions was developed. Most importantly,...

Visible light-induced RAFT polymerization of methacrylates with benzaldehyde derivatives as organophotoredox catalysts

2017 ◽  
Vol 56 (2) ◽  
pp. 229-236 ◽  
Author(s):  
Qian Yang ◽  
Xianhong Zhang ◽  
Wenchao Ma ◽  
Yuhong Ma ◽  
Dong Chen ◽  
...  
Keyword(s):  
Visible Light ◽  
Raft Polymerization ◽  
Benzaldehyde Derivatives

On the immunological properties of penicillins

1971 ◽  
Vol 179 (1057) ◽  
pp. 411-432 ◽  
Keyword(s):  
Proteolytic Enzyme ◽  
Continuous Process ◽  
Polymeric Materials ◽  
Small Peptides ◽  
Physiological Conditions ◽  
Polymer Conjugates ◽  
Protein Polymer ◽  
Penicillanic Acid ◽  
Insoluble Form ◽  
Polyvalent Antigens

Penicilloylated proteins which may be found as impurities in 6-amino-penicillanic acid can be exhaustively digested by pronase to yield amino acids and small peptides. This degradation converts the potent polyvalent antigens into a mixture of mostly monovalent haptens which are much less immunogenic and less capable of eliciting immune reactions in sensitized animals. In order to avoid the contamination of 6-aminopenicillanic acid with a proteolytic enzyme, pronase was converted into a water insoluble form by coupling it with bromoacetyl cellulose. This insoluble derivative of pronase retains its activity and broad specificity. It can be readily removed from the medium upon completion of the impurity degradation, to be used repeatedly in a continuous process. The immunological manifestations associated with penicillins are not completely abolished by removal or degradation of protein impurities. Another important cause for these manifestations appears to be polymeric materials which are formed in penicillins. Such polymeric materials were isolated from ampicillin and shown to be capable of binding spontaneously to proteins (e.g. bovine serum albumin). The protein-polymer conjugates, which are formed under physiological conditions (pH 7.4, 37 °C), were found to be immunogenic and to provoke the formation of polymer-specific antibodies.

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