n-Bu4NI-catalyzed selective dual amination of sp3 C–H bonds: oxidative domino synthesis of imidazo[1,5-c]quinazolines on a gram-scale

2014 ◽  
Vol 50 (33) ◽  
pp. 4302-4304 ◽  
Author(s):  
Dan Zhao ◽  
Teng Wang ◽  
Qi Shen ◽  
Jian-Xin Li
Keyword(s):  
Tandem Reaction ◽  
Metal Free ◽  
Efficient Approach

A facile and efficient approach to the synthesis of imidazo[1,5-c]quinazolines was developed via a tandem reaction following dual sp3 C–H amination under metal-free conditions.

Transition metal-free approach to azafluoranthene scaffolds by aldol condensation/[1+2+3] annulation tandem reaction of isocyanoacetates with 8-(alkynyl)-1-naphthaldehydes

2021 ◽  
Author(s):  
Penghui Dong ◽  
Kashif Majeed ◽  
lingna Wang ◽  
Zijian Guo ◽  
Fengtao Zhou ◽  
...  
Keyword(s):  
Transition Metal ◽  
Aldol Condensation ◽  
Domino Reaction ◽  
Tandem Reaction ◽  
Metal Free ◽  
Successive Formation ◽  
General Synthesis

A transition metal-free aldol condensation/[1+2+3] annulation reaction of isocyanoacetates with 8-(alkynyl)-1-naphthaldehydes has been developed for the general synthesis of azafluoranthenes. This domino reaction enables successive formation of three new bonds...

Electrochemical Synthesis of Quinazolinones by the Metal-Free and Acceptor-Free Dehydrogenation of 2-Aminobenzamides

Synlett ◽  
2020 ◽  
Vol 31 (18) ◽  
pp. 1795-1799
Author(s):  
Qing-Hu Teng ◽  
Yan-Yan Chen ◽  
Yan Yao ◽  
Xiu-Jin Meng
Keyword(s):  
Electrochemical Synthesis ◽  
Metal Free ◽  
Efficient Approach

An efficient approach has been developed for the construction of quinazolin-4(3H)-ones by the selective anodic dehydrogenative oxidation/cyclization of benzylic chlorides and 2-aminobenzamides. The method features acceptor-free and metal-free dehydrogenation of amines to imines; a subsequent intermolecular addition provides the products in moderate to good yields.

Synthesis of dibenzo[a,c]carbazoles from 2-(2-halophenyl)-indoles and iodobenzenes via palladium-catalyzed dual C–H functionalization

2017 ◽  
Vol 15 (32) ◽  
pp. 6808-6812 ◽  
Author(s):  
Lijun Wu ◽  
Guobo Deng ◽  
Yun Liang
Keyword(s):  
Cross Coupling ◽  
Tandem Reaction ◽  
Efficient Approach ◽  
Palladium Catalyzed

We report an efficient approach to synthesize dibenzo[a,c]carbazoles via a palladium-catalyzed cross-coupling tandem reaction.

ChemInform Abstract: Morita-Baylis-Hillman Acetates of Acetylenic Aldehydes: Versatile Synthons for Substituted Pyrroles via a Metal-Free Tandem Reaction.

ChemInform ◽  
2012 ◽  
Vol 43 (6) ◽  
pp. no-no
Author(s):  
Chada Raji Reddy ◽  
Motatipally Damoder Reddy ◽  
Boinapally Srikanth ◽  
Kothakonda Rajendra Prasad
Keyword(s):  
Tandem Reaction ◽  
Metal Free ◽  
Substituted Pyrroles

Efficient 2-sulfolmethyl quinoline formation from 2-methylquinolines and sodium sulfinates under transition-metal free conditions

2015 ◽  
Vol 51 (4) ◽  
pp. 652-654 ◽  
Author(s):  
Fuhong Xiao ◽  
Shuqing Chen ◽  
Ya Chen ◽  
Huawen Huang ◽  
Guo-Jun Deng
Keyword(s):  
Transition Metal ◽  
Metal Free ◽  
Efficient Approach

An efficient approach for 2-sulfolmethyl quinoline formation from 2-methylquinolines and sodium sulfinates is described.

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