Using ancillary ligands to tune the DNA binding properties of self-assembled luminescent metallomacrocycles

2014 ◽  
Vol 50 (29) ◽  
pp. 3859-3861 ◽  
Author(s):  
Haslina Ahmad ◽  
Dipesh Ghosh ◽  
Jim A. Thomas
Keyword(s):  
Dna Binding ◽  
Binding Mode ◽  
Binding Properties ◽  
Ancillary Ligands ◽  
Self Assembled ◽  
Optical Binding ◽  
Dna Binding Properties

The DNA binding mode and optical binding response of a self-assembled metallomacrocycle can be turned through its ancillary ligands.

Synthesis and DNA-binding Properties of a Cationic Seven-coordinate Manganese(II) Complex Formed with the Tripodal Ligand Tris(Nmethylbenzimidazol- 2-ylmethyl)amine and Salicylate

2012 ◽  
Vol 67 (8) ◽  
pp. 819-826 ◽  
Author(s):  
Huilu Wu ◽  
Ying Bai ◽  
Jingkun Yuan ◽  
Hua Wang ◽  
Guolong Pan ◽  
...  
Keyword(s):  
Dna Binding ◽  
Binding Mode ◽  
X Ray Diffraction ◽  
Binding Properties ◽  
Tripodal Ligand ◽  
Spectrophotometric Methods ◽  
Physico Chemical ◽  
Dna Binding Properties ◽  
Hydroxyl Radical Scavenge

A ternary cationic Mn(II) complex with the tripodal ligand tris(2-(N-methyl) benzimidazylmethyl)amine (Mentb), salicylate and DMF as ligands and nitrate as counterion, [Mn(Mentb)(salicylate)DMF](NO3), was synthesized and characterized by physico-chemical and spectroscopic methods. The crystal structure of the Mn(II) complex has been determined by single-crystal X-ray diffraction and revealed that the central Mn(II) atom is seven-coordinated. The DNA-binding properties of the Mn(II) complex were investigated by spectrophotometric methods and viscosity measurements, and the results suggest that the Mn(II) complex binds to DNA via an intercalation binding mode. Additionally, the complex exhibited potential hydroxyl radical scavenge properties in in vitro studies

Synthesis, Crystal Structure, DNA-binding Properties and Antioxidant Activities of a Lutetium(III) Complex with the Bis(N-salicylidene)-3- oxapentane-1,5-diamine Ligand

2013 ◽  
Vol 68 (3) ◽  
pp. 257-266 ◽  
Author(s):  
Guolong Pan ◽  
Yuchen Bai ◽  
Hua Wang ◽  
Jin Kong ◽  
Furong Shi ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Dna Binding ◽  
Antioxidant Activities ◽  
Radical Scavenging ◽  
Binding Mode ◽  
Binding Properties ◽  
Metal Centers ◽  
Spectrophotometric Methods ◽  
Dna Binding Properties

A Schiff base ligand bis(N-salicylidene)-3-oxapentane-1,5-diamine (H2L) and its lutetium(III) complex, with composition Lu2(L)2(NO3)2, were synthesized and characterized by physico-chemical and spectroscopic methods. The crystal structure of the Lu(III) complex has been determined by single-crystal X-ray diffraction. It reveals a centrosymmetric binuclear neutral entity where Lu(III) metal centers are bridged by two phenoxo oxygen atoms. The DNA-binding properties of the Lu(III) complex were investigated by spectrophotometric methods and viscosity measurements, and the results suggest that the Lu(III) complex binds to DNA via a groove binding mode. Additionally, the antioxidant activity of the Lu(III) complex was determined by the superoxide and hydroxyl radical scavenging methods in vitro, which indicate that it is a scavenger for OH· and O-· 2 radicals.

Synthesis, Crystal Structure, and DNA-Binding Studies of a Ni(II) Complex with the Tris(N-methylbenzimidazol-2-ylmethyl)amine Ligand

2010 ◽  
Vol 65 (11) ◽  
pp. 1341-1348 ◽  
Author(s):  
Huilu Wu ◽  
Ke Li ◽  
Tao Sun ◽  
Bin Liu ◽  
Fei Jia ◽  
...  
Keyword(s):  
Dna Binding ◽  
Binding Mode ◽  
Distorted Octahedral Geometry ◽  
X Ray Diffraction ◽  
Binding Studies ◽  
Binding Properties ◽  
Distorted Octahedral ◽  
Elemental Analyses ◽  
Dna Binding Studies ◽  
Dna Binding Properties

A tripod ligand tris(N-methylbenzimidazol-2-ylmethyl)amine (Mentb) and its nickel(II) picrate (pic) complex, with composition [Ni(Mentb)(DMF)(H2O)](pic)2, have been synthesized and characterized on the basis of elemental analyses, molar conductivities, IR spectra, and UV/Vis measurements. Single-crystal X-ray diffraction revealed that the Ni atom is six-coordinated in a distorted octahedral geometry. In addition, the DNA-binding properties of the ligand Mentb and its Ni(II) complex have been investigated by electronic absorption, fluorescence and viscosity measurements. The experimental results suggest that the ligand and its Ni(II) complex bind to DNA via an intercalation binding mode, and their binding affinity to DNA follows the order of complex>ligand.

scholarly journals Synthesis, Crystal Structure, and DNA-Binding Studies of a Nickel(II) Complex with the Bis(2-benzimidazolymethyl)amine Ligand

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Huilu Wu ◽  
Tao Sun ◽  
Ke Li ◽  
Bin Liu ◽  
Fan Kou ◽  
...  
Keyword(s):  
Dna Binding ◽  
Binding Mode ◽  
Coordination Geometry ◽  
Binding Studies ◽  
Binding Properties ◽  
Elemental Analyses ◽  
Dna Binding Studies ◽  
Intercalation Binding ◽  
Dna Binding Properties ◽  
Amine Ligand

A V-shaped ligand Bis(2-benzimidazolymethyl)amine (bba) and its nickel(II) picrate (pic) complex, with composition [Ni(bba)2](pic)2⋅3MeOH, have been synthesized and characterized on the basis of elemental analyses, molar conductivities, IR spectra, and UV/vis measurements. In the complex, the Ni(II) ion is six-coordinated with a N2O4ligand set, resulting in a distorted octahedron coordination geometry. In addition, the DNA-binding properties of the Ni(II) complex have been investigated by electronic absorption, fluorescence, and viscosity measurements. The experimental results suggest that the nickel(II) complex binds to DNA by partial intercalation binding mode.

Homologous 1,3,5-triarylpyrazolines: synthesis, CH⋯π interactions guided self-assembly and effect of alkyloxy chain length on DNA binding properties

2014 ◽  
Vol 38 (11) ◽  
pp. 5617-5625 ◽  
Author(s):  
Faiza Anam ◽  
Asghar Abbas ◽  
Kong Mun Lo ◽  
Zia-ur-Rehman Zia-ur-Rehman ◽  
Shahid Hameed ◽  
...  
Keyword(s):  
Dna Binding ◽  
Chain Length ◽  
Self Assembly ◽  
Binding Constants ◽  
Binding Properties ◽  
Π Interactions ◽  
Self Assembled ◽  
Dna Binding Properties

The synthesis, CH⋯π interactions-driven self-assembled structure and DNA binding properties (105–106M−1binding constants) of new homologous 1,3,5-triaryl-2-pyrazolines are reported.

Synthesis, Characterization, DNA-Binding, and DNA-Photocleavage Properties of RuII Complexes

2009 ◽  
Vol 62 (12) ◽  
pp. 1646 ◽  
Author(s):  
Lifeng Tan ◽  
Xuejiao Chen ◽  
Jianliang Sheng
Keyword(s):  
Dna Binding ◽  
Spectroscopic Methods ◽  
Binding Properties ◽  
Dna Photocleavage ◽  
Ancillary Ligands ◽  
Viscosity Measurements ◽  
Dna Cleaving ◽  
Intercalative Mode ◽  
Polypyridyl Ligand ◽  
Dna Binding Properties

A new polypyridyl ligand 2-benzo[b]thiophen-3-yl-1H-1,3,7,8-tetraazacyclopenta[l]phenanthrene (BTCP) and its RuII complexes [Ru(bpy)2(BTCP)]2+ (1) (bpy = 2,2′-bipyridine), [Ru(phen)2(BTCP)]2+ (2) (phen = 1,10-phenanthroline), and [Ru(dmb)2(BTCP)]2+ (3) (dmb = 4,4′-dimethyl-2,2′-bipyridine), have been synthesized and characterized. The DNA-binding properties of the three complexes were investigated by spectroscopic methods and viscosity measurements. The results indicate that complexes 1, 2, and 3 bind to DNA by an intercalative mode and the ancillary ligands have a significant effect on the binding strengths of RuII complexes to DNA. When irradiated at 365 nm, complex 2 was found to be a more effective DNA-cleaving agent than complexes 1 and 3.

Self-Assembled Hybrid Structures of DNA Block-Copolymers and Nanoparticles with Enhanced DNA Binding Properties

Small ◽  
2010 ◽  
Vol 6 (20) ◽  
pp. 2256-2260 ◽  
Author(s):  
Xi-Jun Chen ◽  
Brenda L. Sanchez-Gaytan ◽  
Sara E. N. Hayik ◽  
Michael Fryd ◽  
Bradford B. Wayland ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Dna Binding ◽  
Hybrid Structures ◽  
Binding Properties ◽  
Self Assembled ◽  
Dna Binding Properties

Relationship between the Structure and the DNA Binding Properties of Diazoniapolycyclic Duplex- and Triplex-DNA Binders:  Efficiency, Selectivity, and Binding Mode†

Biochemistry ◽  
2007 ◽  
Vol 46 (44) ◽  
pp. 12721-12736 ◽  
Author(s):  
Serena Basili ◽  
Anna Bergen ◽  
Francesco Dall'Acqua ◽  
Anita Faccio ◽  
Anton Granzhan ◽  
...  
Keyword(s):  
Dna Binding ◽  
Binding Mode ◽  
Triplex Dna ◽  
Binding Properties ◽  
Dna Binders ◽  
Dna Binding Properties
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