scholarly journals Hydrogen sulfide (H2S) releasing agents: chemistry and biological applications

2014 ◽  
Vol 50 (80) ◽  
pp. 11788-11805 ◽  
Author(s):  
Yu Zhao ◽  
Tyler D. Biggs ◽  
Ming Xian
Keyword(s):  
Hydrogen Sulfide ◽  
Biological Applications ◽  
Feature Article

This Feature Article provides an overview of currently known hydrogen sulfide donors.

Directed adenine functionalization for creating complex architectures for material and biological applications

2017 ◽  
Vol 53 (35) ◽  
pp. 4748-4758 ◽  
Author(s):  
Balaram Mohapatra ◽  
Pratibha Pratibha ◽  
Sandeep Verma
Keyword(s):  
Metal Complexes ◽  
Coordination Polymers ◽  
Gas Adsorption ◽  
Bioactive Molecules ◽  
Biological Applications ◽  
Design Strategies ◽  
Feature Article ◽  
Complex Architectures ◽  
Adenine Derivatives

This feature article outlines design strategies for modified adenine derivatives to construct discrete metal complexes, ring-expanded skeletons, coordination polymers, MOFs, and capped nanoparticles, for applications in gas adsorption, as bioimaging agents and as bioactive molecules.

ChemInform Abstract: Hydrogen Sulfide (H2S) Releasing Agents: Chemistry and Biological Applications

ChemInform ◽  
2014 ◽  
Vol 45 (45) ◽  
pp. no-no ◽  
Author(s):  
Yu Zhao ◽  
Tyler D. Biggs ◽  
Ming Xian
Keyword(s):  
Hydrogen Sulfide ◽  
Biological Applications

Nanoparticles made of π-conjugated compounds targeted for chemical and biological applications

2015 ◽  
Vol 51 (94) ◽  
pp. 16733-16749 ◽  
Author(s):  
Xinjun Xu ◽  
Ronghua Liu ◽  
Lidong Li
Keyword(s):  
Photoacoustic Imaging ◽  
Biological Applications ◽  
Feature Article ◽  
Disease Therapy ◽  
Conjugated Compounds

This feature article summarizes the recent applications of nanoparticles made of π-conjugated compounds in bio/chemo-sensing, disease therapy, and photoacoustic imaging.

Local-structure-dependent luminescence in lanthanide-doped inorganic nanocrystals for biological applications

2021 ◽  
Author(s):  
Huhui Fu ◽  
Yuhan Ma ◽  
Yongsheng Liu ◽  
Maochun Hong
Keyword(s):  
Local Structure ◽  
Biological Applications ◽  
Feature Article ◽  
Recent Advances ◽  
Inorganic Nanocrystals

This feature article overviews the recent advances in the local-structure-dependent luminescence in lanthanide-doped inorganic nanocrystals for various biological applications.

scholarly journals Fluorescent probes for hydrogen sulfide detection and bioimaging

2014 ◽  
Vol 50 (82) ◽  
pp. 12234-12249 ◽  
Author(s):  
Fabiao Yu ◽  
Xiaoyue Han ◽  
Lingxin Chen
Keyword(s):  
Hydrogen Sulfide ◽  
Fluorescent Probes ◽  
Design Strategies ◽  
Feature Article ◽  
Reaction Type

In this feature article, we address the synthesis and design strategies for the development of fluorescent probes for H2S, based on the reaction type between H2S and the probes.

How SIMS microscopy can be used in medicine

1992 ◽  
Vol 50 (2) ◽  
pp. 1602-1603
Author(s):  
Philippe Fragu
Keyword(s):  
Mass Spectrometry ◽  
Biomedical Applications ◽  
Secondary Ion Mass Spectrometry ◽  
Chemical Elements ◽  
Biological Applications ◽  
The Past ◽  
Potential Source ◽  
Secondary Ion ◽  
Chemical Integrity ◽  
Scientific Endeavour

The identification, localization and quantification of intracellular chemical elements is an area of scientific endeavour which has not ceased to develop over the past 30 years. Secondary Ion Mass Spectrometry (SIMS) microscopy is widely used for elemental localization problems in geochemistry, metallurgy and electronics. Although the first commercial instruments were available in 1968, biological applications have been gradual as investigators have systematically examined the potential source of artefacts inherent in the method and sought to develop strategies for the analysis of soft biological material with a lateral resolution equivalent to that of the light microscope. In 1992, the prospects offered by this technique are even more encouraging as prototypes of new ion probes appear capable of achieving the ultimate goal, namely the quantitative analysis of micron and submicron regions. The purpose of this review is to underline the requirements for biomedical applications of SIMS microscopy.Sample preparation methodology should preserve both the structural and the chemical integrity of the tissue.

Endogenous hydrogen sulfide sulfhydrates IKKβ at cysteine 179 to control pulmonary artery endothelial cell inflammation

2019 ◽  
Vol 133 (20) ◽  
pp. 2045-2059 ◽  
Author(s):  
Da Zhang ◽  
Xiuli Wang ◽  
Siyao Chen ◽  
Selena Chen ◽  
Wen Yu ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Endothelial Cell ◽  
Pulmonary Artery ◽  
Cell Model ◽  
Site Directed Mutagenesis ◽  
Critical Event ◽  
Hypertensive Rats ◽  
Pulmonary Artery Endothelial Cell

Abstract Background: Pulmonary artery endothelial cell (PAEC) inflammation is a critical event in the development of pulmonary arterial hypertension (PAH). However, the pathogenesis of PAEC inflammation remains unclear. Methods: Purified recombinant human inhibitor of κB kinase subunit β (IKKβ) protein, human PAECs and monocrotaline-induced pulmonary hypertensive rats were employed in the study. Site-directed mutagenesis, gene knockdown or overexpression were conducted to manipulate the expression or activity of a target protein. Results: We showed that hydrogen sulfide (H2S) inhibited IKKβ activation in the cell model of human PAEC inflammation induced by monocrotaline pyrrole-stimulation or knockdown of cystathionine γ-lyase (CSE), an H2S generating enzyme. Mechanistically, H2S was proved to inhibit IKKβ activity directly via sulfhydrating IKKβ at cysteinyl residue 179 (C179) in purified recombinant IKKβ protein in vitro, whereas thiol reductant dithiothreitol (DTT) reversed H2S-induced IKKβ inactivation. Furthermore, to demonstrate the significance of IKKβ sulfhydration by H2S in the development of PAEC inflammation, we mutated C179 to serine (C179S) in IKKβ. In purified IKKβ protein, C179S mutation of IKKβ abolished H2S-induced IKKβ sulfhydration and the subsequent IKKβ inactivation. In human PAECs, C179S mutation of IKKβ blocked H2S-inhibited IKKβ activation and PAEC inflammatory response. In pulmonary hypertensive rats, C179S mutation of IKKβ abolished the inhibitory effect of H2S on IKKβ activation and pulmonary vascular inflammation and remodeling. Conclusion: Collectively, our in vivo and in vitro findings demonstrated, for the first time, that endogenous H2S directly inactivated IKKβ via sulfhydrating IKKβ at Cys179 to inhibit nuclear factor-κB (NF-κB) pathway activation and thereby control PAEC inflammation in PAH.

Feature Article: Design of Porous Polymeric Materials from Miscellaneous Macromolecular Architectures: An Overview

Polymer News ◽  
2004 ◽  
Vol 29 (7) ◽  
pp. 205-212 ◽  
Author(s):  
Rengarajan Balaji ◽  
Sylvie Boileau ◽  
Philippe Guérin ◽  
Daniel Grande
Keyword(s):  
Polymeric Materials ◽  
Feature Article
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