scholarly journals Stabilization of a hyaluronate-associated gene delivery system using calcium ions

2014 ◽  
Vol 2 (6) ◽  
pp. 936-942 ◽  
Author(s):  
Min Feng ◽  
Basma M. Ibrahim ◽  
Erin M. Wilson ◽  
Kyung-Oh Doh ◽  
Brandon K. Bergman ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Gene Delivery ◽  
Delivery System ◽  
Calcium Ions ◽  
Plasmid Dna ◽  
Ternary Complex ◽  
Gene Delivery System

A “DPH” ternary complex consisting of plasmid DNA (pDNA), intracellularly degradable polyethyleneimine, and hyaluronic acid (HA) was stabilized with Ca2+ ions to prevent aggregation.

scholarly journals Ternary Complex of Plasmid DNA with Protamine and γ-Polyglutamic Acid for Biocompatible Gene Delivery System

2013 ◽  
Vol 36 (11) ◽  
pp. 1794-1799 ◽  
Author(s):  
Kosuke Kanda ◽  
Yukinobu Kodama ◽  
Tomoaki Kurosaki ◽  
Masanobu Imamura ◽  
Hiroo Nakagawa ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Plasmid Dna ◽  
Ternary Complex ◽  
Polyglutamic Acid ◽  
Gene Delivery System

Novel receptor-mediated gene delivery system comprising plasmid/protamine/sugar-containing polyanion ternary complex

Biomaterials ◽  
2004 ◽  
Vol 25 (16) ◽  
pp. 3267-3273 ◽  
Author(s):  
Kazuo Maruyama ◽  
Fumito Iwasaki ◽  
Tomoko Takizawa ◽  
Hironobu Yanagie ◽  
Takuro Niidome ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Ternary Complex ◽  
Gene Delivery System

Transdermal Delivery of Poly-Hyaluronic Acid-Based Spherical Nucleic Acids for Chemogene Therapy

Nanoscale ◽  
2022 ◽  
Author(s):  
Kai Jiang ◽  
Di Zhao ◽  
Rui Ye ◽  
Xinlong Liu ◽  
Chao Gao ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Nucleic Acid ◽  
Gene Delivery ◽  
Nucleic Acids ◽  
Delivery System ◽  
Transdermal Delivery ◽  
Gene Delivery System ◽  
Transdermal Administration ◽  
Spherical Nucleic Acid ◽  
Spherical Nucleic Acids

Spherical nucleic acid (SNA), as a good gene delivery system, has a good application prospect for transdermal administration in skin disorders treatment. However, most of traditional SNA core materials are...

A RAGE-antagonist peptide potentiates polymeric micelle-mediated intracellular delivery of plasmid DNA for acute lung injury gene therapy

Nanoscale ◽  
2020 ◽  
Vol 12 (25) ◽  
pp. 13606-13617
Author(s):  
Chunxian Piao ◽  
Chuanyu Zhuang ◽  
Myoungjee Choi ◽  
Junkyu Ha ◽  
Minhyung Lee
Keyword(s):  
Gene Therapy ◽  
Acute Lung Injury ◽  
Gene Delivery ◽  
Lung Injury ◽  
Delivery System ◽  
Plasmid Dna ◽  
Intracellular Delivery ◽  
Polymeric Micelle ◽  
Gene Delivery System

Pulmonary gene delivery system was developed based on RAGE-antagonist peptide and dexamethasone-conjugated polyamidoamine.

scholarly journals Enhanced Transfection of Human Mesenchymal Stem Cells Using a Hyaluronic Acid/Calcium Phosphate Hybrid Gene Delivery System

Polymers ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 798 ◽  
Author(s):  
Jung Eun Lee ◽  
Yue Yin ◽  
Su Yeon Lim ◽  
E. Seul Kim ◽  
Jaeback Jung ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Hyaluronic Acid ◽  
Calcium Phosphate ◽  
Gene Delivery ◽  
Delivery System ◽  
Gene Transfection ◽  
Human Mesenchymal Stem Cells ◽  
Bone Morphogenetic Protein 2 ◽  
Gene Delivery System

Human mesenchymal stem cells (hMSCs) show enormous potential in regenerative medicine and tissue engineering. However, current use of hMSCs in clinics is still limited because there is no appropriate way to control their behavior in vivo, such as differentiation to a desired cell type. Genetic modification may provide an opportunity to control the cells in an active manner. One of the major hurdles for genetic manipulation of hMSCs is the lack of an efficient and safe gene delivery system. Herein, biocompatible calcium phosphate (CaP)-based nanoparticles stabilized with a catechol-derivatized hyaluronic acid (dopa-HA) conjugate were used as a carrier for gene transfection to hMSCs for improved differentiation. Owing to the specific interactions between HA and CD44 of bone marrow-derived hMSCs, dopa-HA/CaP showed significantly higher transfection in hMSCs than branched polyethylenimine (bPEI, MW 25 kDa) with no cytotoxicity. The co-delivery of a plasmid DNA encoding bone morphogenetic protein 2 (BMP-2 pDNA) and micro RNA 148b (miRNA-148b) by dopa-HA/CaP achieved significantly improved osteogenic differentiation of hMSCs.

Tumor regression after systemic administration of a novel tumor-targeted gene delivery system carrying a therapeutic plasmid DNA

2010 ◽  
Vol 143 (2) ◽  
pp. 215-221 ◽  
Author(s):  
Swati Koppu ◽  
Yew Jinn Oh ◽  
RuAngelie Edrada-Ebel ◽  
David R. Blatchford ◽  
Laurence Tetley ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Plasmid Dna ◽  
Tumor Regression ◽  
Systemic Administration ◽  
Gene Delivery System ◽  
Targeted Gene Delivery
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