Simultaneous determination of whitening agents and parabens in cosmetic products by capillary electrophoresis with on-line sweeping enhancement

2014 ◽  
Vol 6 (19) ◽  
pp. 7615-7620 ◽  
Author(s):  
I-Chi Tsai ◽  
Chia-Yu Su ◽  
Cho-Chun Hu ◽  
Tai-Chia Chiu
Keyword(s):  
Capillary Electrophoresis ◽  
Simultaneous Determination ◽  
Separation Efficiency ◽  
Analysis Time ◽  
Cosmetic Products ◽  
Short Analysis Time ◽  
On Line ◽  
High Separation

An on-line sweeping-MEKC method for simultaneous determination of whitening agents and parabens in commercial cosmetic products was demonstrated. This approach was shown to offer high separation efficiency, short analysis time, and convenience of analysis. The LODs of the analytes were in the range from 8 to 162 nM (1.1 to 21.0 ng mL−1) and a 46 to 279-fold enhancement was achieved.

scholarly journals Microassay of amiodarone and desethylamiodarone in serum by capillary electrophoresis with head-column field-amplified sample stacking

1996 ◽  
Vol 42 (11) ◽  
pp. 1805-1811 ◽  
Author(s):  
C X Zhang ◽  
Y Aebi ◽  
W Thormann
Keyword(s):  
Capillary Electrophoresis ◽  
Detection Limit ◽  
Linear Response ◽  
Separation Efficiency ◽  
Operating Costs ◽  
Serum Samples ◽  
Sample Stacking ◽  
Liquid Handling ◽  
High Separation

Abstract Binary-system capillary electrophoresis (CE) with head-column field-amplified sample stacking permits determination of amiodarone and desethylamiodarone in 20-microL serum samples. The assay is characterized by a detection limit for both compounds of 80 nmol/L and by excellent linear response over the recommended therapeutic range for amiodarone (1.5-4 mumol/L). Intra- and interday reproducibilities (CVs) between 3% and 6% and run times of approximately 10 min are comparable with those for conventional HPLC. Besides excellent sensitivity, attractive features of the assay include low operating costs, high separation efficiency, rapid drug extraction, consumption of almost negligible amounts of organic solvents, and simple operation. If appropriate microvessels and liquid-handling facilities are available, the same assay can be performed with 2 microL of serum, and if the serum is not diluted but rather is concentrated during extraction, < 1 nmol/L of amiodarone can be detected.

Simultaneous determination of five metal ions by on-line complexion combined with micelle to solvent stacking in capillary electrophoresis

Talanta ◽  
2020 ◽  
Vol 209 ◽  
pp. 120578
Author(s):  
Xiaoyu Song ◽  
Rui Zhang ◽  
Yue Wang ◽  
Mengqing Feng ◽  
Honghua Zhang ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Metal Ions ◽  
Simultaneous Determination ◽  
On Line

scholarly journals Dual 2-Hydroxypropyl-β-Cyclodextrin and 5,10,15,20-Tetrakis (4-Hydroxyphenyl) Porphyrin System as a Novel Chiral-Achiral Selector Complex for Enantioseparation of Aminoalkanol Derivatives with Anticancer Activity in Capillary Electrophoresis

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 993
Author(s):  
Błażej Grodner ◽  
Mariola Napiórkowska
Keyword(s):  
Capillary Electrophoresis ◽  
Anticancer Agents ◽  
Chiral Discrimination ◽  
Combined Effects ◽  
Pilot Studies ◽  
Repeatability And Reproducibility ◽  
The Stability ◽  
Short Time ◽  
High Separation

In this study, a complex consisting of 2-hydroxypropyl-β-cyclodextrin and 5,10,15,20-tetrakis (4-hydroxyphenyl) porphyrin, (named dual chiral-achiral selector complex) was used for the determination of two novel potential anticancer agents of (I) and (II) aminoalkanol derivatives. This work aimed at developing an effective method that can be utilized for the determination of I (S), I (R), and II (S) and II (R) enantiomers of (I) and (II) compounds through the use of a dual chiral-achiral selector complex consisting of hydroxypropyl-β-cyclodextrin and 5,10,15,20-tetrakis (4-hydroxyphenyl) porphyrin system by applying capillary electrophoresis. This combination proved to be beneficial in achieving high separation selectivity due to the combined effects of different modes of chiral discrimination. The enantiomers of (I) and (II) compounds were separated within a very short time of 3.6–7.2 min, in pH 2.5 phosphate buffer containing 2-hydroxypropyl-β-cyclodextrin and 5,10,15,20-tetrakis (4-hydroxyphenyl) porphyrin system at a concentration of 5 and 10 mM, respectively, at 25 °C and +10 kV. The detection wavelength of the detector was set at 200 nm. The LOD for I (S), I (R), II (S), and II (R) was 65.2, 65.6, 65.1, and 65.7 ng/mL, respectively. LOQ for I (S), I (R), II (S), and II (R) was 216.5, 217.8, 217.1, and 218.1 ng/mL, respectively. Recovery was 94.9–99.9%. The repeatability and reproducibility of the method based on the values of the migration time, and the area under the peak was 0.3–2.9% RSD. The stability of the method was determined at 0.1–4.9% RSD. The developed method was used in the pilot studies for determining the enantiomers I (S), I (R), II (S), and II (R) in the blood serum.

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