Magnetic high throughput screening system for the development of nano-sized molecularly imprinted polymers for controlled delivery of curcumin

The Analyst ◽  
2015 ◽  
Vol 140 (9) ◽  
pp. 3113-3120 ◽  
Author(s):  
Elena V. Piletska ◽  
Bashar H. Abd ◽  
Agata S. Krakowiak ◽  
Anitha Parmar ◽  
Demi L. Pink ◽  
...  
Keyword(s):  
Controlled Release ◽  
Molecularly Imprinted Polymers ◽  
High Throughput Screening ◽  
Cost Effective ◽  
Controlled Delivery ◽  
Screening System ◽  
Microtitre Plate ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Effective Development

A novel format of the microtitre plate equipped with magnetic inserts allows rapid and cost-effective development of the controlled release materials.

A High-Throughput Screening of N-Carbobenzoxy-L-Tryptophan Imprinted Polymers and their Application for Monolithic Chiral Stationary Phase

2012 ◽  
Vol 535-537 ◽  
pp. 1525-1528 ◽  
Author(s):  
Jian Qi ◽  
Li Guo ◽  
Hai Feng Sang
Keyword(s):  
Stationary Phase ◽  
Molecularly Imprinted Polymers ◽  
High Throughput Screening ◽  
Chiral Stationary Phase ◽  
Binding Capacity ◽  
Low Cost ◽  
Small Scale ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Chiral Selectivity

Molecular imprinting is a technique to prepare polymers with predetermined selectivity, specific recognition and predesigned affinity to a desired molecule. The stability and low cost of molecularly imprinted polymers (MIPs) render them attractive for a broad range of applications. Currently, MIP technique has been widely used in chiral separation. In this study, a series of molecularly imprinted polymers for N-Carbobenzoxy-L-tryptophan (N-Cbz-L-Trp) synthesized in different conditions were prepared in a small scale to simulate the monolithic chiral stationary phases (CSPs) primarily. By coupling in situ processing and batch rebinding evaluation, the type of functional monomers, which likely to affect the chiral selectivity of MIPs, was investigated. It was found that a MIP comprising a mixture of functional monomer 4-vinylpyridine (4-VP) and porogen 1-dodecanol/toluene exhibited the highest binding capacity and chiral selectivity for N-Carbobenzoxy-L-tryptophan. Thereafter, the monolithic MIP synthesized in screened optimum condition is used as chiral stationary phase in HPLC, which shows favourable separating capacity.

Molecularly imprinted polymers for enhanced impregnation and controlled release of l-tyrosine

2018 ◽  
Vol 131 ◽  
pp. 283-292 ◽  
Author(s):  
Vanessa R.A. Ferreira ◽  
Manuel A. Azenha ◽  
Carlos M. Pereira ◽  
A. Fernando Silva
Keyword(s):  
Controlled Release ◽  
Molecularly Imprinted Polymers ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

scholarly journals Smart Bandage Based on Molecularly Imprinted Polymers (MIPs) for Diclofenac Controlled Release

2018 ◽  
Vol 11 (4) ◽  
pp. 92 ◽  
Author(s):  
Ortensia Parisi ◽  
Mariarosa Ruffo ◽  
Luca Scrivano ◽  
Rocco Malivindi ◽  
Antonio Vassallo ◽  
...  
Keyword(s):  
Controlled Release ◽  
Molecularly Imprinted Polymers ◽  
Specific Binding ◽  
Skin Irritation ◽  
Spherical Particles ◽  
Batch Adsorption ◽  
Scatchard Analysis ◽  
Binding Studies ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

The aim of the present study was the development of a “smart bandage” for the topical administration of diclofenac, in the treatment of localized painful and inflammatory conditions, incorporating Molecularly Imprinted Polymers (MIPs) for the controlled release of this anti-inflammatory drug. For this purpose, MIP spherical particles were synthesized by precipitation polymerization, loaded with the therapeutic agent and incorporated into the bandage surface. Batch adsorption binding studies were performed to investigate the adsorption isotherms and kinetics and the selective recognition abilities of the synthesized MIP. In vitro diffusion studies were also carried out using Franz cells and the obtained results were reported as percentage of the diffused dose, cumulative amount of diffused drug, steady-state drug flux and permeability coefficient. Moreover, the biocompatibility of the developed device was evaluated using the EPISKIN™ model. The Scatchard analysis indicated that the prepared MIP is characterized by the presence of specific binding sites for diclofenac, which are not present in the corresponding non-imprinted polymer, and the obtained results confirmed both the ability of the prepared bandage to prolong the drug release and the absence of skin irritation reactions. Therefore, these results support the potential application of the developed “smart bandage” as topical device for diclofenac sustained release.

scholarly journals Development of Water-Compatible Molecularly Imprinted Polymers Based on Functionalized β-Cyclodextrin for Controlled Release of Atropine

Polymers ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 130 ◽  
Author(s):  
Yahui He ◽  
Shaomei Zeng ◽  
A. M. Abd El-Aty ◽  
Ahmet Hacımüftüoğlu ◽  
Woldemariam Kalekristos Yohannes ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Molecularly Imprinted Polymers ◽  
Isotherm Models ◽  
Template Molecule ◽  
Stimuli Responsive ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Potential Applications

Herein, a novel method for molecularly imprinted polymers (MIPs) using methacrylic acid functionalized beta-cyclodextrin (MAA-β-CD) monomer is presented, which was designed as a potential water-compatible composite for the controlled release of atropine (ATP). The molecularly imprinted microspheres with pH-sensitive characteristics were fabricated using thermally-initiated precipitation polymerization, employing ATP as a template molecule. The effects of different compounds and concentrations of cross-linking agents were systematically investigated. Uniform microspheres were obtained when the ratio between ATP, MAA-β-CD, and trimethylolpropane trimethacrylate (TRIM) was 1:4:20 (mol/mol/mol) in polymerization system. The ATP loading equilibrium data was best suited to the Freundlich and Langmuir isotherm models. The in vitro drug release study was assessed under simulated oral administration conditions (pH 1.5 and 7.4). The potential usefulness of MIPs as drug delivery devices are much better than non-molecularly imprinted polymers (NIPs). The study shows that the prepared polymers are a pH stimuli-responsive system, which controlled the release of ATP, indicating the potential applications in the field of drug delivery.

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