Rapid screening of classic galactosemia patients: a proof-of-concept study using high-throughput FTIR analysis of plasma

The Analyst ◽  
2015 ◽  
Vol 140 (7) ◽  
pp. 2280-2286 ◽  
Author(s):  
Caroline Lacombe ◽  
Valérie Untereiner ◽  
Cyril Gobinet ◽  
Mokhtar Zater ◽  
Ganesh D. Sockalingum ◽  
...  
Keyword(s):  
Rare Disease ◽  
High Throughput ◽  
Rapid Screening ◽  
Ftir Analysis ◽  
Proof Of Concept ◽  
New Approach ◽  
Classic Galactosemia ◽  
Concept Study

FTIR as a new approach to screen a rare disease.

A proof-of-concept study: evaluating the applicability of high-throughput screening data and read-across tools for food relevant chemicals

2018 ◽  
Vol 295 ◽  
pp. S142
Author(s):  
J.L. Nguyen ◽  
A. Maier ◽  
J. Ovesen ◽  
N. Kleinstreuer ◽  
R. Judson ◽  
...  
Keyword(s):  
High Throughput ◽  
High Throughput Screening ◽  
Proof Of Concept ◽  
Concept Study

Automated disposable small scale reactor for high throughput bioprocess development: A proof of concept study

2013 ◽  
Vol 110 (12) ◽  
pp. 3126-3138 ◽  
Author(s):  
Rachel Bareither ◽  
Neil Bargh ◽  
Robert Oakeshott ◽  
Kathryn Watts ◽  
David Pollard
Keyword(s):  
High Throughput ◽  
Small Scale ◽  
Proof Of Concept ◽  
Bioprocess Development ◽  
Concept Study ◽  
Scale Reactor ◽  
High Throughput Bioprocess Development

scholarly journals Human Pluripotent Stem Cell-derived Cortical Neurons for High Throughput Medication Screening in Autism: A Proof of Concept Study in SHANK3 Haploinsufficiency Syndrome

EBioMedicine ◽  
2016 ◽  
Vol 9 ◽  
pp. 293-305 ◽  
Author(s):  
Hélène Darville ◽  
Aurélie Poulet ◽  
Frédérique Rodet-Amsellem ◽  
Laure Chatrousse ◽  
Julie Pernelle ◽  
...  
Keyword(s):  
Stem Cell ◽  
High Throughput ◽  
Cortical Neurons ◽  
Pluripotent Stem Cell ◽  
Proof Of Concept ◽  
Human Pluripotent Stem Cell ◽  
Concept Study ◽  
Medication Screening

scholarly journals A Semiquantitative FIA-ESI-MS Method for the Rapid Screening of Hypericum perforatum Crude Extracts

2010 ◽  
Vol 5 (3) ◽  
pp. 1934578X1000500 ◽  
Author(s):  
Anna Piovan ◽  
Raffaella Filippini ◽  
Rosy Caniato
Keyword(s):  
High Throughput ◽  
High Throughput Screening ◽  
Quantitative Data ◽  
Plant Material ◽  
Hypericum Perforatum ◽  
Complex Mixtures ◽  
Rapid Screening ◽  
New Approach ◽  
Esi Ms ◽  
Suppression Effects

A method based on FIA-ESI-MS has been developed to profile the major constituents of Hypericum perforatum extracts. The objective was to obtain simultaneous semi-quantitative data on hypericin, chlorogenic acid, rutin, quercitrin, quercetin and hyperforin contents for a high-throughput screening of the raw plant material. The principal drawback of FIA-ESI analysis of complex mixtures involves ion suppression effects: the ionization of some components of the mixture can be severely suppressed by ionization of others. The results show that this problem can be alleviated using a new approach to generate calibration curves.

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