An attenuated total reflection (ATR) and Raman spectroscopic investigation into the effects of chloroquine on Plasmodium falciparum-infected red blood cells

The Analyst ◽  
2015 ◽  
Vol 140 (7) ◽  
pp. 2236-2246 ◽  
Author(s):  
M. Kozicki ◽  
D. J. Creek ◽  
A. Sexton ◽  
B. J. Morahan ◽  
A. Wesełucha-Birczyńska ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Plasmodium Falciparum ◽  
Fourier Transform ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Total Reflection ◽  
Attenuated Total Reflection ◽  
Raman Spectroscopic ◽  
Human Red Blood Cells ◽  
Ftir And Raman Spectroscopy

Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR) and Raman spectroscopy were used to compare chloroquine (CQ)-treated and untreated cultured Plasmodium falciparum-infected human red blood cells (iRBCs).

Fine mapping of Plasmodium falciparum ribosomal phosphoprotein PfP0 revealed sequences with highly specific binding activity to human red blood cells

2009 ◽  
Vol 88 (1) ◽  
pp. 61-74 ◽  
Author(s):  
Gabriela Arevalo-Pinzon ◽  
Hernando Curtidor ◽  
Claudia Reyes ◽  
Martha Pinto ◽  
Carolina Vizcaíno ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Red Blood Cells ◽  
Fine Mapping ◽  
Blood Cells ◽  
Specific Binding ◽  
Binding Activity ◽  
Human Red Blood Cells

Plasmodium falciparum rhoptry neck protein 5 peptides bind to human red blood cells and inhibit parasite invasion

Peptides ◽  
2014 ◽  
Vol 53 ◽  
pp. 210-217 ◽  
Author(s):  
Hernando Curtidor ◽  
Liliana C. Patiño ◽  
Gabriela Arévalo-Pinzón ◽  
Magnolia Vanegas ◽  
Manuel E. Patarroyo ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Parasite Invasion ◽  
Human Red Blood Cells ◽  
Rhoptry Neck Protein

Identification of Plasmodium falciparum MSP‐1 peptides able to bind to human red blood cells

1996 ◽  
Vol 18 (10) ◽  
pp. 515-526 ◽  
Author(s):  
MAURICIO URQUIZA ◽  
LUIS E. RODRIGUEZ ◽  
JORGE E. SUAREZ ◽  
FANNY GUZMÁN ◽  
MARISOL OCAMPO ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Human Red Blood Cells

scholarly journals Rosetting of Plasmodium falciparum-infected red blood cells with uninfected red blood cells enhances microvascular obstruction under flow conditions

Blood ◽  
1991 ◽  
Vol 78 (3) ◽  
pp. 812-819 ◽  
Author(s):  
DK Kaul ◽  
EF Jr Roth ◽  
RL Nagel ◽  
RJ Howard ◽  
SM Handunnetti
Keyword(s):  
Plasmodium Falciparum ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Peripheral Resistance ◽  
Inverse Correlation ◽  
Rosette Formation ◽  
Flow Conditions ◽  
Human Red Blood Cells ◽  
Venular Endothelium

Abstract The occurrence of rosetting of Plasmodium falciparum-infected human red blood cells (IRBC) with uninfected red blood cells (RBC) and its potential pathophysiologic consequences were investigated under flow conditions using the perfused rat mesocecum vasculature. Perfusion experiments were performed using two knobby (K+) lines of P falciparum, ie, rosetting positive (K+R+) and rosetting negative (K+R-). The infusion of K+R+ IRBC resulted in higher peripheral resistance (PRU) than K+R- IRBC (P less than .0012). Video microscopy showed that under conditions of flow, in addition to cytoadherence of K+R+ IRBC to the venular endothelium, rosette formation was also restricted to venules, especially in the areas of slow flow. Rosettes were absent in arterioles and were presumably dissociated by higher wall shear rates. The presence of rosettes in the venules must therefore reflect their rapid reformation after disruption. Cytoadherence of K+R+ IRBC was characterized by formation of focal clusters along the venular wall. In addition, large aggregates of RBC were frequently observed at venular junctions, probably as a result of interaction between flowing rosettes, free IRBC, and uninfected RBC. In contrast, the infusion of K+R+ IRBC resulted in diffuse cytoadherence of these cells exclusively to the venular endothelium but not in rosetting or large aggregate formation. The cytoadherence of K+R+ IRBC showed strong inverse correlation with the venular diameter (r = -.856, P less than .00001). Incubation of K+R+ IRBC with heparin and with monoclonal antibodies to glycoprotein IV/CD36 abolished the rosette formation and resulted in decreased PRU and microvascular blockage. These findings demonstrate that rosetting of K+R+ IRBC with uninfected RBC enhances vasocclusion, suggesting an important in vivo role for rosetting in the microvascular sequestration of P falciparum-infected RBC.

Establishment of a SCID mouse model having circulating human red blood cells and a possible growth of Plasmodium falciparum in the mouse

Vaccine ◽  
1995 ◽  
Vol 13 (15) ◽  
pp. 1389-1392 ◽  
Author(s):  
Masayoshi Tsuji ◽  
Chiaki Ishihara ◽  
Satoru Arai ◽  
Rumi Hiratai ◽  
Ichiro Azuma
Keyword(s):  
Plasmodium Falciparum ◽  
Mouse Model ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Scid Mouse ◽  
Human Red Blood Cells ◽  
Scid Mouse Model

scholarly journals Quantitative Imaging of Human Red Blood Cells Infected with Plasmodium falciparum

2010 ◽  
Vol 99 (3) ◽  
pp. 953-960 ◽  
Author(s):  
Alessandro Esposito ◽  
Jean-Baptiste Choimet ◽  
Jeremy N. Skepper ◽  
Jakob M.A. Mauritz ◽  
Virgilio L. Lew ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Quantitative Imaging ◽  
Human Red Blood Cells

Two MSA 2 peptides that bind to human red blood cells are relevant to Plasmodium falciparum merozoite invasion

2000 ◽  
Vol 55 (3) ◽  
pp. 216-223 ◽  
Author(s):  
M. Ocampo ◽  
M. Urquiza ◽  
F. Guzmán ◽  
L.E. Rodriguez ◽  
J. Suarez ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Merozoite Invasion ◽  
Human Red Blood Cells ◽  
Falciparum Merozoite
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