scholarly journals Development of Transmission Raman Spectroscopy towards the in line, high throughput and non-destructive quantitative analysis of pharmaceutical solid oral dose

The Analyst ◽  
2015 ◽  
Vol 140 (1) ◽  
pp. 107-112 ◽  
Author(s):  
Julia A. Griffen ◽  
Andrew W. Owen ◽  
Pavel Matousek
Keyword(s):  
Raman Spectroscopy ◽  
Quantitative Analysis ◽  
Oral Dose ◽  
High Throughput ◽  
Pharmaceutical Tablets ◽  
Transmission Raman ◽  
Non Destructive

Transmission Raman Spectroscopy and photon diode enhancer facilitates faster scanning and quantitative analysis of pharmaceutical tablets.

Quantitative analysis and measurement of carbon isotopic compositions in individual fluid inclusions by micro-laser Raman spectrometry

2016 ◽  
Vol 8 (37) ◽  
pp. 6730-6738 ◽  
Author(s):  
Jiajia Li ◽  
Rongxi Li ◽  
Bangsheng Zhao ◽  
Ning Wang ◽  
Jinghua Cheng
Keyword(s):  
Raman Spectroscopy ◽  
Quantitative Analysis ◽  
Fluid Inclusions ◽  
Laser Raman Spectroscopy ◽  
Raman Spectrometry ◽  
Laser Raman ◽  
Isotopic Compositions ◽  
Carbon Isotopic ◽  
Non Destructive

Micro-laser Raman spectroscopy is a non-destructive technique to quantitatively determine the carbon isotopic compositions of CO2 in individual fluid inclusions.

Quantitative Transmission Raman Spectroscopy of Pharmaceutical Tablets and Capsules

2007 ◽  
Vol 61 (11) ◽  
pp. 1211-1218 ◽  
Author(s):  
Jonas Johansson ◽  
Anders Sparén ◽  
Olof Svensson ◽  
Staffan Folestad ◽  
Mike Claybourn
Keyword(s):  
Raman Spectroscopy ◽  
Pharmaceutical Tablets ◽  
Transmission Raman

Characterisation of transmission Raman spectroscopy for rapid quantitative analysis of intact multi-component pharmaceutical capsules

2011 ◽  
Vol 54 (3) ◽  
pp. 463-468 ◽  
Author(s):  
Michael D. Hargreaves ◽  
Neil A. Macleod ◽  
Mark R. Smith ◽  
Darren Andrews ◽  
Stephen V. Hammond ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Quantitative Analysis ◽  
Transmission Raman

scholarly journals Quantification of Solute Composition in H2O-NaCl-CaCl2 Solutions Using Cryogenic 2D Raman Mapping

Minerals ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 1043
Author(s):  
Haixia Chu ◽  
Guoxiang Chi ◽  
Chunji Xue
Keyword(s):  
Raman Spectroscopy ◽  
Quantitative Analysis ◽  
Fluid Inclusions ◽  
Molar Fraction ◽  
Mapping Technique ◽  
Raman Mapping ◽  
Point Analysis ◽  
Single Inclusion ◽  
Solute Composition ◽  
Non Destructive

Various analytical techniques have been developed to determine the solution composition of fluid inclusions, including destructive, non-destructive, single-inclusion, and bulk-inclusion methods. Cryogenic Raman spectroscopy, as a non-destructive and single-inclusion method, has emerged as a potentially powerful tool of quantitative analysis of fluid inclusion composition. A method of point analysis using cryogenic Raman spectroscopy has been previously proposed to quantitatively estimate the solute composition of H2O-NaCl-CaCl2 solutions, but there are uncertainties related to heterogeneity of frozen fluid inclusions and potential bias in the processing of Raman spectra. A new method of quantitative analysis of solute composition of H2O-NaCl-CaCl2 solutions using Raman mapping technology is proposed in this study, which can overcome the problems encountered in the point analysis. It is shown that the NaCl/(NaCl + CaCl2) molar ratio of the solution, X(NaCl, m), can be related to the area fraction of hydrohalite over hydrohalite plus antarcticite, Fhydrohalite, by the equation X(NaCl, m) = 1.1435 Fhydrohalite − 0.0884, where Fhydrohalite = hydrohalite area/(hydrohalite area + antarcticite area). This equation suggests that the molar fraction of a salt component may be estimated from the fraction of the Raman peak area of the relevant hydrate. This study has established a new way of estimating solute composition of fluid inclusions using cryogenic Raman mapping technique, which may be extended to other solutions.

Investigation of the Sensitivity of Transmission Raman Spectroscopy for Polymorph Detection in Pharmaceutical Tablets

2017 ◽  
Vol 71 (8) ◽  
pp. 1856-1867 ◽  
Author(s):  
Hanzhou Feng ◽  
Robert W. Bondi ◽  
Carl A. Anderson ◽  
James K. Drennen ◽  
Benoît Igne
Keyword(s):  
Raman Spectroscopy ◽  
Pharmaceutical Tablets ◽  
Transmission Raman
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