Optical diagnosis of the progression and reversal of CCl4-induced liver injury in rodent model using minimally invasive autofluorescence spectroscopy

The Analyst ◽  
2015 ◽  
Vol 140 (11) ◽  
pp. 3773-3780 ◽  
Author(s):  
Shaiju S. Nazeer ◽  
S. Sandhyamani ◽  
Ramapurath S. Jayasree
Keyword(s):  
Liver Injury ◽  
Minimally Invasive ◽  
Rodent Model ◽  
Spectral Features ◽  
Optical Diagnosis ◽  
Schematic Representation ◽  
Autofluorescence Spectroscopy

Schematic representation of the degree of intoxicant-induced liver injury and regeneration and the minimally invasive analysis using autofluorescence spectral features.

scholarly journals A minimally invasive catheter-based ultrasound technology for therapeutic interventions in brain: initial preclinical studies

2018 ◽  
Vol 44 (2) ◽  
pp. E13 ◽  
Author(s):  
Goutam Ghoshal ◽  
Lucy Gee ◽  
Tamas Heffter ◽  
Emery Williams ◽  
Corinne Bromfield ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Minimally Invasive ◽  
Focused Ultrasound ◽  
Ex Vivo ◽  
Experimental Studies ◽  
Rodent Model ◽  
Therapeutic Interventions ◽  
Porcine Liver

OBJECTIVEMinimally invasive procedures may allow surgeons to avoid conventional open surgical procedures for certain neurological disorders. This paper describes the iterative process for development of a catheter-based ultrasound thermal therapy applicator.METHODSUsing an ultrasound applicator with an array of longitudinally stacked and angularly sectored tubular transducers within a catheter, the authors conducted experimental studies in porcine liver, in vivo and ex vivo, in order to characterize the device performance and lesion patterns. In addition, they applied the technique in a rodent model of Parkinson’s disease to investigate the feasibility of its application in brain.RESULTSThermal lesions with multiple shapes and sizes were readily achieved in porcine liver. The feasibility of catheter-based focused ultrasound in the treatment of brain conditions was demonstrated in a rodent model of Parkinson’s disease.CONCLUSIONSThe authors show proof of principle of a catheter-based ultrasound system that can create lesions with concurrent thermode-based measurements.

scholarly journals Cepharanthine alleviates liver injury in a rodent model of limb ischemia–reperfusion

2016 ◽  
Vol 54 (1) ◽  
pp. 11-15 ◽  
Author(s):  
Yin-Kuang Chang ◽  
Su-Cheng Huang ◽  
Ming-Chang Kao ◽  
Chun-Jen Huang
Keyword(s):  
Liver Injury ◽  
Ischemia Reperfusion ◽  
Limb Ischemia ◽  
Rodent Model

scholarly journals Minimally invasive gas embolization using acoustic droplet vaporization in a rodent model of hepatocellular carcinoma

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Jonah S. Harmon ◽  
Foad Kabinejadian ◽  
Robinson Seda ◽  
Mario L. Fabiilli ◽  
Sibu Kuruvilla ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Minimally Invasive ◽  
Rodent Model ◽  
Acoustic Droplet Vaporization ◽  
Droplet Vaporization

Salivary Raman Spectroscopy: Standardization of Sampling Protocols and Stratification of Healthy and Oral Cancer Subjects

2020 ◽  
pp. 000370282097326
Author(s):  
Arti Hole ◽  
Gunjan Tyagi ◽  
Atul Deshmukh ◽  
Raviraj Deshpande ◽  
Vikram Gota ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Oral Cancer ◽  
Minimally Invasive ◽  
Cancer Diagnostics ◽  
Spectral Features ◽  
Sample Collection ◽  
Linear Discriminant ◽  
Sampling Protocols ◽  
Whole Saliva

Minimally invasive cancer detection using bio-fluids has been actively pursued due to practical limitations, though there are better suited noninvasive and online in vivo methods. Saliva is one such clinically informative bio-fluid that offers the advantages of easy and multiple sample collection. Despite its potential in cancer diagnostics, saliva analysis is challenging due to its heterogeneous composition. Recently, there has been an upsurge in saliva exploration using optical techniques. Forms of saliva such as precipitate and supernatant have been monitored, but this sampling method needs to be standardized due to the obvious loss of analytes in processing. In that context, present work details the comparison of four different saliva sampling methodologies, i.e., air-dried, lyophilized, pellet, and supernatant using Raman spectroscopy collected from 10 healthy samples. Composition-driven spectral features of all forms were compared and classified using principal component analysis and linear discriminant analysis. Analysis was carried out on all four groups in the first step. In the second step, groups of pellet and supernatant , and air-dried and lyophilized were analyzed. Findings suggest that pellet and supernatant exhibit discrete spectroscopic features and demonstrate high classification efficiency, which is indicative of their distinctive biochemical composition. On the other hand, air-dried and lyophilized forms showed overlapping spectral features and low classification, suggesting these forms retain majority spectroscopic features of whole saliva and are less prone to sampling losses. Thus, this study indicates air-dried and lyophilized forms may be more appropriate for saliva sampling using Raman spectroscopy providing the comprehensive information required for cancer diagnosis. Furthermore, the method was also tested for the classification of oral cancer and healthy subjects ( n = 27) which yielded 90% stratification. The findings of the study indicate the utility of minimally invasive salivary Raman-based diagnostics in oral cancers.

scholarly journals Protective Role of Terminalia bellirica (Gaertn.) Roxb Fruits Against CCl4 Induced Oxidative Stress and Liver Injury in Rodent Model

2018 ◽  
Vol 34 (2) ◽  
pp. 155-163 ◽  
Author(s):  
Kuriakose Jayesh ◽  
Lal Raisa Helen ◽  
A. Vysakh ◽  
Eldhose Binil ◽  
M. S. Latha
Keyword(s):  
Oxidative Stress ◽  
Liver Injury ◽  
Protective Role ◽  
Rodent Model ◽  
Terminalia Bellirica

scholarly journals The importance of radiologic and minimally invasive adjuncts in the nonoperative management of major penetrating liver injury

Injury Extra ◽  
2005 ◽  
Vol 36 (10) ◽  
pp. 463-465
Author(s):  
Matthew J. Martin ◽  
Andrew L. Tang ◽  
Seth M. Fischman ◽  
Robert Casillas ◽  
Demetrios Demetriades
Keyword(s):  
Liver Injury ◽  
Minimally Invasive ◽  
Nonoperative Management

Traumatic bile leaks from blunt liver injury in children: A multidisciplinary and minimally invasive approach to management

2014 ◽  
Vol 49 (3) ◽  
pp. 424-427 ◽  
Author(s):  
Afif N. Kulaylat ◽  
Audrey L. Stokes ◽  
Brett W. Engbrecht ◽  
J. Steele McIntyre ◽  
Susan E. Rzucidlo ◽  
...  
Keyword(s):  
Liver Injury ◽  
Minimally Invasive ◽  
Minimally Invasive Approach ◽  
Invasive Approach ◽  
Blunt Liver Injury ◽  
Bile Leaks

Effects of Steroids on Fetal Rat Liver

1969 ◽  
Vol 27 ◽  
pp. 350-351
Author(s):  
F. G. Zaki
Keyword(s):  
Liver Injury ◽  
Rat Liver ◽  
Fetal Liver ◽  
Dosage Level ◽  
Maternal Plasma ◽  
Methyl Prednisolone ◽  
Fetal Rat ◽  
Toxic Agents ◽  
Fetal Rat Liver ◽  
Neonatal Liver

Fetal and neonatal liver injury induced by agents circulating in maternal plasma, even though well recognized, its morphological manifestations are not yet established. As part of our studies of fetal and neonatal liver injury induced by maternal nutritional disorders, metabolic impairment and toxic agents, the effects of two anti-inflammatory steroids have been recently inves tigated.Triamcinolone and methyl prednisolone were injected each in a group of rats during pregnancy at a-dosage level of 2 mgm three times a week. Fetal liver was studied at 18 days of gestation. Litter size and weight markedly decreased than those of control rats. Stillbirths and resorption were of higher incidence in the triamcinolone group than in those given the prednisolone.

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