Schiff base derivatives containing heterocycles with aggregation-induced emission and recognition ability

2014 ◽  
Vol 2 (15) ◽  
pp. 2684-2691 ◽  
Author(s):  
Gang Liu ◽  
Mingdi Yang ◽  
Lianke Wang ◽  
Jun Zheng ◽  
Hongping Zhou ◽  
...  
Keyword(s):  
Schiff Base ◽  
Aggregation Induced Emission ◽  
Schiff Base Derivatives ◽  
Recognition Ability

Three new Schiff base derivatives possessing vagarious blue aggregation-induced emission (AIE) characteristics in tetrahydrofuran (THF)–water were synthesized.

Intermolecular interactions boost aggregation induced emission in carbazole Schiff base derivatives

2017 ◽  
Vol 15 (1) ◽  
pp. 256-264 ◽  
Author(s):  
Xiaoping Gan ◽  
Guangjin Liu ◽  
Mingjie Chu ◽  
Wengang Xi ◽  
Zili Ren ◽  
...  
Keyword(s):  
Schiff Base ◽  
Intermolecular Interactions ◽  
Significant Role ◽  
Structure Property ◽  
Aggregation Induced Emission ◽  
Π Interactions ◽  
Property Relationship ◽  
Schiff Base Derivatives ◽  
Structure Property Relationship

The structure–property relationship was discussed and we found that the C–H⋯π interactions and H⋯H interactions played a significant role in AIE performance.

Highly sensitive and selective fluorescent sensor for copper(ii) based on salicylaldehyde Schiff-base derivatives with aggregation induced emission and mechanoluminescence

2017 ◽  
Vol 41 (19) ◽  
pp. 11079-11088 ◽  
Author(s):  
Xiaoli Yang ◽  
Wenyan Zhang ◽  
Zihan Yi ◽  
Hao Xu ◽  
Jun Wei ◽  
...  
Keyword(s):  
Schiff Base ◽  
Schiff Bases ◽  
Fluorescent Sensor ◽  
Aggregation Induced Emission ◽  
Schiff Base Derivatives ◽  
Highly Sensitive

The present study provides valuable information for designing materials with AIE, Cu2+ sensor and MFC properties based on Schiff-bases.

scholarly journals Correction: Intermolecular interactions boost aggregation induced emission in carbazole Schiff base derivatives

2017 ◽  
Vol 15 (9) ◽  
pp. 2119-2119 ◽  
Author(s):  
Xiaoping Gan ◽  
Guangjin Liu ◽  
Mingjie Chu ◽  
Wengang Xi ◽  
Zili Ren ◽  
...  
Keyword(s):  
Schiff Base ◽  
Intermolecular Interactions ◽  
Aggregation Induced Emission ◽  
Schiff Base Derivatives

Correction for ‘Intermolecular interactions boost aggregation induced emission in carbazole Schiff base derivatives’ by Xiaoping Gan, et al., Org. Biomol. Chem., 2017, 15, 256–264.

Multiple-color aggregation-induced emission (AIE) molecules as chemodosimeters for pH sensing

2016 ◽  
Vol 52 (15) ◽  
pp. 3123-3126 ◽  
Author(s):  
Qi Feng ◽  
Yuanyuan Li ◽  
Lili Wang ◽  
Chen Li ◽  
Jinmin Wang ◽  
...  
Keyword(s):  
Schiff Base ◽  
Ph Sensing ◽  
Aggregation Induced Emission ◽  
Schiff Base Derivatives

A series of 4-N,N-dimethylaminoaniline salicylaldehyde Schiff-base derivatives (DAS) were facilely prepared.

Difunctional chemosensor for Cu(ii) and Zn(ii) based on Schiff base modified anthryl derivative with aggregation-induced emission enhancement and piezochromic characteristics

2015 ◽  
Vol 3 (9) ◽  
pp. 1994-2002 ◽  
Author(s):  
Mingdi Yang ◽  
Yan Zhang ◽  
Weiju Zhu ◽  
Huizhen Wang ◽  
Jing Huang ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Schiff Base ◽  
Fluorescent Properties ◽  
Simple Method ◽  
Aggregation Induced Emission ◽  
Schiff Base Derivatives ◽  
Emission Enhancement

Three new anthryl Schiff base derivatives containing a similar molecular structure were synthesized through a simple method and their fluorescent properties were investigated in detail.

Efficacy of Novel Schiff base Derivatives as Antifungal Compounds in Combination with Approved Drugs Against Candida Albicans

2019 ◽  
Vol 15 (6) ◽  
pp. 648-658 ◽  
Author(s):  
Manzoor Ahmad Malik ◽  
Shabir Ahmad Lone ◽  
Parveez Gull ◽  
Ovas Ahmad Dar ◽  
Mohmmad Younus Wani ◽  
...  
Keyword(s):  
Schiff Base ◽  
Candida Albicans ◽  
Antifungal Activity ◽  
Fungal Infections ◽  
Total Sterol ◽  
Antifungal Drugs ◽  
New Drugs ◽  
Ergosterol Biosynthesis ◽  
Dependent Manner ◽  
Schiff Base Derivatives

Background: The increasing incidence of fungal infections, especially caused by Candida albicans, and their increasing drug resistance has drastically increased in recent years. Therefore, not only new drugs but also alternative treatment strategies are promptly required. Methods: We previously reported on the synergistic interaction of some azole and non-azole compounds with fluconazole for combination antifungal therapy. In this study, we synthesized some non-azole Schiff-base derivatives and evaluated their antifungal activity profile alone and in combination with the most commonly used antifungal drugs- fluconazole (FLC) and amphotericin B (AmB) against four drug susceptible, three FLC resistant and three AmB resistant clinically isolated Candida albicans strains. To further analyze the mechanism of antifungal action of these compounds, we quantified total sterol contents in FLC-susceptible and resistant C. albicans isolates. Results: A pyrimidine ring-containing derivative SB5 showed the most potent antifungal activity against all the tested strains. After combining these compounds with FLC and AmB, 76% combinations were either synergistic or additive while as the rest of the combinations were indifferent. Interestingly, none of the combinations was antagonistic, either with FLC or AmB. Results interpreted from fractional inhibitory concentration index (FICI) and isobolograms revealed 4-10-fold reduction in MIC values for synergistic combinations. These compounds also inhibit ergosterol biosynthesis in a concentration-dependent manner, supported by the results from docking studies. Conclusion: The results of the studies conducted advocate the potential of these compounds as new antifungal drugs. However, further studies are required to understand the other mechanisms and in vivo efficacy and toxicity of these compounds.

scholarly journals Synthesis and Evaluation of Schiff Bases of 4-Amino-5-(chlorine substituted phenyl)-4H-1,2,4-triazole-3-thione as Antimicrobial Agents

2020 ◽  
Vol 41 (1) ◽  
pp. 26-35
Author(s):  
Kishor Devkota ◽  
Govinda Pathak ◽  
Bhushan Shakya
Keyword(s):  
Schiff Base ◽  
Schiff Bases ◽  
Antimicrobial Agents ◽  
Triazole Ring ◽  
Antimicrobial Activities ◽  
Biologically Active ◽  
Spectral Techniques ◽  
Schiff Base Derivatives ◽  
Bacteria And Fungi ◽  
Different Strains

Triazole ring system has attracted a continuously growing interest of synthetic organic chemists and those dealing with the medicinal compounds due to its versatile potential to interact with biological systems. Schiff bases are also considered as one of the most biologically active compounds.  The aim of the present study was to synthesize new Schiff bases bearing triazole nucleus and to assess their antimicrobial activities. Four new Schiff base derivatives of 1,2,4-triazole-3-thione were synthesized by combining two different pharmacophores viz. triazole nucleus and Schiff base moiety and were characterized by spectral techniques (UV, FT-IR, and NMR). The Schiff bases were evaluated for antibacterial (Staphylococcus aureus, Escherichia coli, and Klebsiella pneumoniae) and antifungal (Candida albicans) activities. The synthesized compounds exhibited good to moderate activities against different strains of bacteria and fungi tested.

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